Analysis of the mechanism of interferon production in plasmacytoid dendritic cells

• Project/Area Number: 15H06454
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Experimental pathology
• Research Institution: Kagawa University
• Principal Investigator: SAIGA HIROYUKI 香川大学, 医学部, 助教 (40752499)
• Project Period (FY): 2015-08-28 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 形質細胞様樹状細胞 / インターフェロン / PDC / I型IFN / 発現制御機構 / 免疫学 / 分子メカニズム

Outline of Final Research Achievements

Plasmacytoid dendritic cells (pDC) secrete type I IFNs, which play an important role in antiviral immune responses. However, the molecular mechanisms of type I IFNs production in pDC are still not completely understood. Here we show that transcription factor HS01 regulates the production of type I IFNs in pDC.