next generation cell therapy using gene editing and tissue engineering
| Project/Area Number |
15H06503
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Digestive surgery
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| Research Institution | Nagasaki University |
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Principal Investigator |
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| Project Period (FY) |
2015-08-28 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | IL10 / 食道再生 / 食道狭窄 / トランスレーショナルリサーチ / 移植再生医療 / 幹細胞 / 炎症 / 線維化 / サイトカイン |
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| Outline of Final Research Achievements |
We have established the epithelial cell sheet transplantation to prevent esophageal strictures after endoscopic surgery. However, epithelial cell sheet therapy is not expected to prevent esophageal strictures with the severe inflammationary conditions such as corrosive esophagitis and post-radiation therapy. The purpose of this study was that the relationships between epithelial cells and anti-inflammationary cytokines were revealed. We performed the histological examination using chemical mucosal defects models in control and IL-10KO mice. In IL-10KO mice, the fibrosis after chemical mucosal defect continuously increased. The body weight was decreased. We concluded IL-10 strongly influenced the fibrosis in the scarred stage.
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Report
(3 results)
Research Products
(11 results)
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[Journal Article] Relationship between immune function recovery and infectious complications in patients following living donor liver transplantation.2016
Author(s)
Shinichiro Kobayashi, Akihiko Soyama, Mitsuhisa Takatsuki, Masaaki Hidaka, Tomohiko Adachi, Amane Kitasato, Ayaka Kinoshita, Takanobu Hara, Kengo Kanetaka, Fumihiko Fujita, Tamotsu Kuroki, Susumu Eguchi
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Journal Title
Hepatology research
Volume: 46
Issue: 9
Pages: 908-915
DOI
NAID
Related Report
Peer Reviewed
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