Striatal plasticity during acquisition of Sensory-motor learning

• Project/Area Number: 15H06530
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Developmental mechanisms and the body works
• Research Institution: Fukushima Medical University
• Principal Investigator: Setogawa Susumu 福島県立医科大学, 医学部, 博士研究員 (30760508)
• Project Period (FY): 2015-08-28 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 線条体 / 知覚―運動学習 / 運動学習 / 小動物脳機能イメージング法 / 知覚－運動学習 / 身体教育学 / 弁別課題 / 意思決定 / 聴覚弁別課題 / 大脳基底核 / スポーツ科学

Outline of Final Research Achievements

Striatum, which is one of the nuclei in basal ganglia, has an important role in sensory-motor learning. Recently, it has been reported that the task-related region shifts between the dorsolateral and the dorsomedial parts of striatum during this learning. However little is known when and how the responsible area in the striatum shifts during acquisition of associative learning. In this study, we assessed dynamic changes in patterns of the brain activation at different learning stages during an auditory discrimination task using a small-animal neuroimaging. Voxel-based statistical parametric mapping analysis revealed that the neural activities in the dorsolateral striatum increased in the middle learning phase, then turned to decrease at later learning phase. These findings suggest that the sensory-motor learning evokes dynamic shift of regional brain activation pattern within striatum.

Research Products

• [Presentation] Dynamic shifts of regional brain activitactivation patterny during acquisition of an auditory discrimination task (2017)
  • Author(s): Setogawa, S., Okauchi, T., Hu, D., Shigeta, M., Hayashinaka, E., Onoe, K., Wada, Y., Hikishima, K., Onoe, H., Cui, YL., Kobayashi, K.,
  • Organizer: The 40th Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: 千葉県
  • Year and Date: 2017-07-20
• [Presentation] 知覚・運動学習に伴う脳神経回路シフトの動態メカニズム解明に向けて (2017)
  • Author(s): 瀬戸川将
  • Organizer: 第9回PET化学ミーティング
  • Place of Presentation: 神戸
  • Year and Date: 2017-02-20
• [Presentation] Small-animal Neuroimaging-based Integrated Approaches for Brain Science (2016)
  • Author(s): Seogawa, S., and Cui YL.,
  • Organizer: The 7th international neural microcircuit conference Recent advances in the analysis of cortical microcircuits
  • Place of Presentation: Aichi, Japan
  • Year and Date: 2016-11-08
  • Int'l Joint Research / Invited
• [Presentation] PETを用いた単一レバー押し課題中の学習依存的な神経活動の変化 (2016)
  • Author(s): 30.瀬戸川将，岡内隆，井口善雄，和田康弘，林中恵美，疋島啓吾，崔翼龍，小林和人
  • Organizer: 第71回日本体力医学会大会
  • Place of Presentation: 岩手県
  • Year and Date: 2016-09-23