Crosstalk mechanism between autophagy and apoptosis for the development of novel cancer therapy
| Project/Area Number |
15H06550
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
General pharmacology
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| Research Institution | Osaka City University |
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Principal Investigator |
Doi Kenichiro 大阪市立大学, 大学院医学研究科, 病院講師 (80382050)
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| Project Period (FY) |
2015-08-28 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | オートファジー / アポトーシス / 癌治療 / 薬剤併用療法 / Autophagy / Apoptosis / Crosstalk mechanism / ネクロプトーシス / 低分子化合物 |
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| Outline of Final Research Achievements |
In recent years, elucidation of crosstalk mechanisms of autophagy and apoptosis is a global trend in the field of cancer treatment. Since cancer cells are easy to acquire drug resistance and infiltration / metastasis ability, it is essential to develop therapeutic methods that take biodiversity into consideration. It is important to develop a combination therapy to efficiently induce cancer cell death by confirming whether autophagy is also called "double-edged sword" and whether it is beneficial for cancer cell survival. In this research project we examined rat kidney cancer cell line and highly lung metastatic lines and confirmed that combinations of drugs with various inhibitors in order to suppress or induce autophagy. Pharmacological methods were mainly used to address this problem and we hope to find a novel evidence in cancer therapeutics.
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Report
(3 results)
Research Products
(11 results)
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[Journal Article] Acid ceramidase is upregulated in AML and represents a novel therapeutic target.2016
Author(s)
Tan SF, Liu X, Fox TE, Barth BM, Sharma A, Turner SD, Awwad A, Dewey A, Doi K, Spitzer B, Shah MV, Morad SA, Desai D, Amin S, Zhu J, Liao J, Yun J, Kester M, Claxton DF, Wang HG, Cabot MC, Schuchman EH, Levine RL, Feith DJ, Loughran TP Jr.
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Journal Title
Oncotarget
Volume: 7
Issue: 50
Pages: 83208-83222
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] The role of deltaNp63pos CD44vpos cells in the development of NTCU-induced peripheral type of mouse lung squamous cell carcinomas..2016
Author(s)
Yamano S, Gi M, Tago Y, Doi K, Okada S, Hirayama S, Tachibana H, Ishii N, Fujioka M, Tatsumi K,Wanibuchi H.
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Journal Title
Cancer Sci
Volume: 107
Issue: 2
Pages: 123-132
DOI
Related Report
Peer Reviewed / Open Access
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