Verifying the exacerbating effect of titanium oxide nanoparticles on inflammation

• Project/Area Number: 15H06567
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Prosthodontics/ Dental materials science and
• Research Institution: Meikai University
• Principal Investigator: KOBAYASHI Masahiko 明海大学, 歯学部, 助教 (20758271)
• Research Collaborator: SAKAGAMI Hiroshi 明海大学, 歯学部, 教授 ; OKUDAIRA Noriyuki 明海大学, 歯学部, 助教
• Project Period (FY): 2015-08-28 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 酸化チタン / 炎症反応 / ナノマテリアル / COX-2 / 酸化チタンナノ粒子

Outline of Final Research Achievements

Titanium dioxide (TiO2) nanotube is emerging as a provocative target for oral implant research. The aim of this study was to evaluate the effect of UV on the wettability behavior, bacterial colonization and fibroblast proliferation rate on TiO2 nanotube surfaces prepared using different anodization voltages, aimed to be used an implant abutment material.
UV treatment enhances the wettability behavior of TiO2 nanotube surfaces and could result in lower bacterial adhesion and biofilm formation. Moreover, TiO2 induced inflammatory response in increasing Cyclooxyrgenase (COX-2) expression by western blotting methods.

Research Products

• [Presentation] Fiber-reinforced composite as an oral implant abutment material (2016)
  • Author(s): Masahiko Kobayashi, Lippo Lassila, Pekka Vallittu, Timo Narhi
  • Organizer: 94th General session & exhibition of the IADR
  • Place of Presentation: 韓国 (Seoul)
  • Year and Date: 2016-06-22
  • Int'l Joint Research
• [Presentation] The effect of ultraviolet treatment on surface characteristics, bacterial adhesion, and cellular response of TiO2 nanotubes (2016)
  • Author(s): M. Kobayashi, A. Abdulmajeed, J. Moon, R. Punkkinen, J. Shimada, P. Vallittu, L. Lassila
  • Organizer: American Association for Dental Research Annual Meeting & Exhibition
  • Place of Presentation: Los Angeles, Calif., USA
  • Year and Date: 2016-03-16
  • Int'l Joint Research