Study on the pathogenesis and drug metabolism of designer drug-related deaths

Research Project

Project/Area Number	15H06628
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	Legal medicine
Research Institution	Tokyo Medical University
Principal Investigator	MAEDA Hideyuki 東京医科大学, 医学部, 助教 (60407963)
Project Period (FY)	2015-08-28 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords	危険ドラッグ / 横紋筋融解症 / セロトニン症候群
Outline of Final Research Achievements	We reported on the first lethal case of 25B-NBOMe, a law-evading (dangerous) drug, which presented with symptoms of serotonin syndrome including hyperthermia and rhabdomyolysis. Accordingly, we administered 25B-NBOMe at 5ng/kg～10mg/kg i.p. in rats, but could not reproduce the syndrome. However, we could reproduce rhabdomyolysis in zebrafish. Therefore, we planned to clarify the mechanism underlying the rhabdomyolysis.

Report

(2 results)