Effect of Synthetic Bone Mineral to Osseointegration in a Rat Model of Osteoporosis

• Project/Area Number: 15H06645
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Prosthodontics/ Dental materials science and
• Research Institution: Nihon University
• Principal Investigator: WATANABE Takehiro 日本大学, 松戸歯学部, 助手(専任扱) (80759986)
• Project Period (FY): 2015-08-28 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: サプリメント / 骨粗鬆症 / インプラント / 歯学

Outline of Final Research Achievements

The purpose of the present study was to confirm whether intake of Synthetic bone mineral (SBM) developed for osteoporosis supplement, affect peri-implant bone formation in an ovariectomized rat.
Pull-out strength and BMD for the Diet with SBM group were significantly greater than those without SBM group.Fluorescence microscopy imaging of the Diet with SBM group demonstrated more green fluorescence (indicating bone formation) than that of the Diet without SBM group. BV/TV, BS/BV, TbTh and Vtr in the Diet with SBM group were significantly greater than those in the Diet without SBM group. This study demonstrated that SBM could be effective in accelerating peri-implant bone formation and improve the trabecular structure in an ovariectomized rat.

Research Products

• [Journal Article] Effect of a dietary supplement on peri-implant bone strength in a rat model of osteoporosis (2016)
  • Author(s): Takahashi, T. Watanabe, T. Nakada, H. Tanimoto, Y. Kimoto, S. Mijares, D. Q. Zhang, Y. Kawai, Y.
  • Journal Title: Journal of Prosthodontic Research Volume: 60 Issue: 2 Pages: 131-137
  • DOI: 10.1016/j.jpor.2015.12.006
  • NAID: 130005172131
  • ISSN: 1883-1958, 1883-9207
  • Year and Date: 2016-04-25
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Improved Bone Micro Architecture Healing Time after Implant Surgery in an Ovariectomized Rat (2016)
  • Author(s): Takahashi, T. Watanabe, T. Nakada, H. T, H. Sato, Y. Tanimoto, T. Sakae, S. Kimoto, Mijares, D. Q. Zhang, Y. Kawai, Y.
  • Journal Title: Journal of Hard Tissue Biology Volume: 25 Issue: 3 Pages: 257-262
  • DOI: 10.2485/jhtb.25.257
  • NAID: 130005163161
  • ISSN: 1341-7649, 1880-828X
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] Study on Synthetic Bone Mineral to Shorten Implant Treatment in a Rat Model of Osteoporosis (2017)
  • Author(s): Takehiro Watanabe Takahiro Takahashi, Hiroshi Nakada, Hiroki sato2, Daisuke Isaji, Yasuhiro Tanimoto, Suguru Kimoto, and Yasuhiko Kawai
  • Organizer: IADR/AADR/CADR GENERAL SESSION & EXHIBITION; SAN FRANCISCO, CALIF.
  • Place of Presentation: Moscone Center（San francisco・America）
  • Year and Date: 2017-03-22
  • Int'l Joint Research
• [Presentation] サプリメントの摂取が 骨粗鬆症モデルラットの インプラント体周囲骨の骨形成に与える影響 (2016)
  • Author(s): 髙橋卓裕、渡辺丈紘、佐藤博紀、中田浩史、飯島守雄、 伊藤誠康、岡田裕之、河相安彦
  • Organizer: 第46回日本口腔インプラント学会
  • Place of Presentation: 名古屋国際会議場（愛知県・名古屋市）
  • Year and Date: 2016-09-16
• [Presentation] 骨粗鬆症ラットにおけるインプラント体周囲骨の微小構造に対するサプリメントの影響 (2016)
  • Author(s): 渡辺丈紘、高橋卓裕、佐藤博紀、谷本安浩、中田浩史、木本統、北村彩、佐藤佳奈美、飯島守雄、河相安彦
  • Organizer: 公益社団法人日本補綴歯科学会第125回学術大会
  • Place of Presentation: 石川県立音楽堂（石川県・金沢市）
  • Year and Date: 2016-07-08
• [Presentation] 骨粗鬆症モデルラットにおいて SBM の経口摂取が骨形成作用に与える影響 (2016)
  • Author(s): 石渡幸志、渡辺丈紘、 高橋卓裕、 佐藤博紀、谷本安浩、中田浩史、梅木賢人、木本統、河相安彦
  • Organizer: 公益社団法人日本補綴歯科学会第125回学術大会
  • Place of Presentation: 石川県立音楽堂（石川県・金沢市）
  • Year and Date: 2016-07-08