The improvement effect of periodontal disease by cacao bean extract
| Project/Area Number |
15H06697
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Epidemiology and preventive medicine
|
|---|
| Research Institution | Kanagawa Dental College |
|---|
Principal Investigator |
Sasaki Haruka 神奈川歯科大学, 大学院歯学研究科, 特別研究員 (50757200)
|
|---|
| Project Period (FY) |
2015-08-28 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Keywords | カカオ抽出物 / カカオ豆抽出物 / 歯周病 / 抗菌効果 / 抗酸化 |
|---|
| Outline of Final Research Achievements |
It is reported that cocoa bean extract has the inhibition effects of the collagenase produced by Porphyromonas gingivalis (P. gingivalis) such as the periodontal pathogenic bacteria. Therefore, we assessed the improvement effect of periodontal disease using cocoa bean extract (CBP and PW-VE-R) against P. gingivalis. The antimicrobial activity of cocoa bean against P. gingivalis and biofilm was recognized by using CBP and PW-VE-R. In addition, the scavenging activities against the reactive oxygen species such superoxide and hydroxyl radical wer indicated with cocoa bean extract. These results suggested that cocoa bean extract might have the improvement effect on periodontal tissue destruction.
|
Report
(3 results)
Research Products
(4 results)
-
[Journal Article] Protective effects of (6R)-5,6,7,8-tetrahydro-L-biopterin on local ischemia/reperfusion-induced suppression of reactive hyperemia in rat gingiva2016
Author(s)
Tanaka Y, Toyama T, Wada-Takahashi S, Sasaki H, Miyamoto C, Maehata Y, Yoshino F, Yoshida A, Takahashi S-S, Watanabe K, Lee M-C, Todoki K, Hamada N
-
Journal Title
Journal of Clinical Biochemistry and Nutrition
Volume: 58
Issue: 1
Pages: 69-75
DOI
NAID
ISSN
0912-0009, 1880-5086
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
-
-
