The development of method for bone formation surround dental implant using the synthetic oligopeptide derived from emdogain.

• Project/Area Number: 15H06742
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Prosthodontics/ Dental materials science and
• Research Institution: Osaka Dental University
• Principal Investigator: KATAYAMA Nobuhito 大阪歯科大学, 歯学部, 講師(非常勤) (00761842)
• Research Collaborator: KATO Hirohito 大阪歯科大学, 歯学部, 助教 ; YAMAWAKI Isao 大阪歯科大学, 歯学部, 大学院生 ; TAGUCHI Yoichiro 大阪歯科大学, 歯学部, 准教授 ; UMEDA Makoto 大阪歯科大学, 歯学部, 教授
• Project Period (FY): 2015-08-28 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: エムドゲイン / インプラント / 合成ペプチド / 骨増生 / 幹細胞

Outline of Final Research Achievements

In the present study, we investigated whether a synthetic oligopeptide derived from EMD can contribute the induction of bone formation surround dental implant.
We found the synthetic oligopeptide promote the cell proliferation and hard tissue formation, so the synthetic oligopeptide might be useful for bone formation in the treatment of dental implant.

Research Products

• [Journal Article] Effect of Glucose Concentration on the pH and Growth of <i>Streptococcus mutans</i> and <i>Porphyromonas gingivalis</i> (2016)
  • Author(s): Isao Yamawaki, Yoichiro Taguchi, Hirohito Kato, Makiko Okuda, Nobuhito Katayama, Naoki, Muneyasu Shida, Ikuo Nishikawa, Isao Tamura, Tatsuro Miyake, Hiroshi Maeda Makoto Umeda
  • Journal Title: Jpn J Conserv Dent Volume: 58 Issue: 6 Pages: 510-517
  • DOI: 10.11471/shikahozon.58.510
  • NAID: 130005119225
  • ISSN: 0387-2343, 2188-0808
  • Year and Date: 2016-01-06
  • Peer Reviewed