Development of non-invasive diagnostic system for kidney disease using intestinal bacterial flora profile and metabolite analysis

• Project/Area Number: 15H06800
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Hygiene and public health
• Research Institution: Fukuoka Dental College
• Principal Investigator: Tanaka Shigeru 福岡歯科大学, 口腔歯学部, 助教 (80596396)
• Project Period (FY): 2015-08-28 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 腸内細菌 / 糸球体腎炎 / 腎生検 / 慢性腎臓病 / 定量的核酸同定検査 / リスクモデル / 病理学 / 細菌 / ゲノム / 腎臓病

Outline of Final Research Achievements

The aim of this study is to clarify the composition pattern of gut microflora specific to each histological diagnosis using feces of patients with glomerular disease diagnosed by percutaneous renal biopsy. Furthermore, we aim to develep a non-invasive and accurate comprehensive diagnostic system for renal disease.

Research Products

• [Journal Article] The Fukuoka Kidney disease Registry (FKR) study: design and methods. (2016)
  • Author(s): Tanaka S, Ninomiya T, Fujisaki K, Yoshida H, Nagata M, Masutani K, Tokumoto M, Mitsuiki K, Hirakata H, Fujimi S, Kiyohara Y, Kitazono T, Tsuruya K.
  • Journal Title: Clin Exp Nephrol Volume: in press
  • Peer Reviewed
• [Journal Article] Comparative effectiveness of oral versus intravenous vitamin D receptor activators on infection-related mortality in hemodialysis patients: the Q-Cohort Study. (2016)
  • Author(s): Tanaka S, Ninomiya T, Taniguchi T, Fujisaki K, Tokumoto M, Hirakata H, Ooboshi H, Kitazono T, Tsuruya K.
  • Journal Title: Nephrol Dial Transplant Volume: 19 Pages: 1062-70
  • Peer Reviewed
• [Journal Article] Extended Swan-Neck Catheter With Upper Abdominal Exit-Site Reduces Peritoneal Dialysis-Related Infections. (2016)
  • Author(s): Eriguchi M, Tsuruya K, Yoshida H, Haruyama N, Tanaka S, Tsuchimoto A, Fusisaki K, Torisu K, Masutani K, Kitazono T.
  • Journal Title: Ther Apher Dial. Volume: 20 Pages: 158-64
  • Peer Reviewed
• [Journal Article] Assessment of urinary angiotensinogen as a marker of podocyte injury in proteinuric nephropathies. (2016)
  • Author(s): Eriguchi M, Yotsueda R, Torisu K, Kawai Y, Hasegawa S, Tanaka S, Noguchi H, Masutani K, Kitazono T, Tsuruya K.
  • Journal Title: Am J Physiol Renal Physiol Volume: 15 Pages: 322-33
  • Peer Reviewed
• [Journal Article] Prognostic impact of serum bilirubin level on long-term renal survival in IgA nephropathy (2015)
  • Author(s): Shigeru Tanaka, Toshiharu Ninomiya, Kosuke Masutani, Masaharu Nagata, Akihiro Tsuchimoto, Kazuhiko Tsuruya, Takanari Kitazono
  • Journal Title: Clinical and experimental nephrology Volume: 19(6) Pages: 1062-1070
  • Peer Reviewed
• [Presentation] 血液透析患者における治療抵抗性高血圧と心血管リスクの関連：Qコホート研究 (2016)
  • Author(s): 田中茂
  • Organizer: 第61回日本透析医学会学術集会
  • Place of Presentation: 大阪
• [Presentation] IgA腎症におけるレニン・アンジオテンシン系抑制薬の末期腎不全発症抑制効果 (2016)
  • Author(s): 田中茂
  • Organizer: 第58回日本腎臓学会学術総会
  • Place of Presentation: 名古屋
• [Presentation] The effect of renin-angiotensin system blockade on the incidence of end-stage renal disease in IgA nephropathy. (2016)
  • Author(s): Tanaka S, et al.
  • Organizer: Kidney Week 2016
  • Place of Presentation: Chicago
• [Presentation] Tanaka S, Ninomiya T, Katafuchi R, Masutani K, Nagata M, Tsuchimoto A, Hirakata H, Tsuruya K, Kitazono T. (2015)
  • Author(s): The effect of renin-angiotensin system blockade on the incidence of end-stage renal disease in IgA nephropathy.
  • Organizer: American Society of Nephrology, Kidney Week 2015
  • Place of Presentation: San Diego CA, United States
  • Year and Date: 2015-11-05
  • Int'l Joint Research
• [Presentation] Comparative Effectiveness of Oral and Injectable Vitamin D Receptor Activator on Infectious Mortality in Hemodialysis Patients: the Q Cohort Study. (2015)
  • Author(s): Tanaka S, Ninomiya T, Taniguchi M, Tokumoto M, Hirakata H, Ooboshi H, Tsuruya K, Kitazono T.
  • Organizer: American Society of Nephrology, Kidney Week 2015
  • Place of Presentation: San Diego CA, United States
  • Year and Date: 2015-11-05
  • Int'l Joint Research