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Start-up study for the promotion mechanisms of diabetic nephropathy by oral bacteria and the preventive dentistry

Research Project

Project/Area Number 15H06802
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Social dentistry
Research InstitutionFukuoka Dental College

Principal Investigator

Takata Shunsuke  福岡歯科大学, 口腔歯学部, 医員 (10757826)

Project Period (FY) 2015-08-28 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords糖尿病 / 腎症 / Porphyromonas gingivalis / lipopolysaccharide / toll-like receptor / 糖尿病性腎症 / 糖尿病マウス / 歯周病 / 糸球体硬化 / 終末糖化産物 / 1型コラーゲン / ストレプトゾトシン / 1型糖尿病
Outline of Final Research Achievements

We found that renal glomeruli in diabetic environment express toll-like receptors (TLR), and that diabetic mice administering periodontal pathogenic substances become nephropathy but healthy mice do not become nephropathy. TLR is an immune molecule that is primarily expressed on leukocyte, which recognizes bacteria and causes inflammation. Healthy blood vessels do not normally express. In heavy periodontitis, bacteria enter easily into the blood with brushing teeth, so it is thought that in human with both diabetes and periodontitis bacteria enter into the blood and arrive at the kidney, and nephropathy occurs by combining bacteria with TLR which is expressed in diabetic glomeruli. Therefore, it was concluded that treatment and prevention of periodontal disease in human with diabetes is very important for prevention of nephropathy.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • Research Products

    (4 results)

All 2017 2016

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (3 results) (of which Int'l Joint Research: 3 results)

  • [Journal Article] Effects of TLR4 blocking on diabetic nephropathy promoted by the Porphyromonas gingivalis lipopolysaccharide.2017

    • Author(s)
      Kajiwara, K., Takata S., To, T., Takara, K., Hatakeyama, Y., Tamaoki, S., Darveau, R., Ishikawa, I., Sawa, Y.
    • Journal Title

      Diabetology & Metabolic Syndrome

      Volume: 印刷中

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] The cytokine inductions in glomerular endothelial cells with Porphyromonas gingivalis lipopolysaccharide yhrough TLR2.2016

    • Author(s)
      Takata, S., Kajiwara, K., Hatakeyama, Y., Ishikawa, H., Sawa, Y.
    • Organizer
      94th International Association of Dental Research
    • Place of Presentation
      Seoul
    • Year and Date
      2016-06-24
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The cytokine inductions in glomerular endothelial cells with Porphyromonas gingivalis lipopolysaccharide through TLR22016

    • Author(s)
      Takata S, Kajiwara K, Hatakeyama Y, Ishikawa H, Sawa Y.
    • Organizer
      International Association of Dental Research
    • Place of Presentation
      Seoul
    • Year and Date
      2016-06-22
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Porphyromonas gingivalis lipopolysaccharide promote diabetic nephropathy through TLR22016

    • Author(s)
      Kajiwara K, Takata S, Hatakeyama Y, Ishikawa H, Sawa Y.
    • Organizer
      International Association of Dental Research
    • Place of Presentation
      Seoul
    • Year and Date
      2016-06-22
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research

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Published: 2015-08-26   Modified: 2018-03-22  

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