Biosynthetic pathway for C15 conjugated diene aldehyde sex pheromone

Research Project

Project/Area Number	15H06854
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	Insect science
Research Institution	National Agriculture and Food Research Organization (2016) 国立研究開発法人農業生物資源研究所 (2015)
Principal Investigator	Uehara Takuya 国立研究開発法人農業・食品産業技術総合研究機構, 生物機能利用研究部門昆虫制御研究領域, 研究員 (80756023)
Project Period (FY)	2015-08-28 – 2017-03-31
Project Status	Completed (Fiscal Year 2016)
Budget Amount *help	¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000) Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords	性フェロモン / 性フェロモン生合成 / スズメガ / 奇数炭素性フェロモン / サザナミスズメ / 昆虫 / 奇数炭素鎖性フェロモン
Outline of Final Research Achievements	Conjugated diene aldehyde 9,11-pentadecadienal was isolated from a hawk moth Dolbina tancrei. Its odd-carbon chain structure is unique as a natural product, therefore the molecular mechanism for biosynthesis is unknown. In this study, chemical analysis of precursors of the sex pheromone in female moth, incorporation experiment of deuterium labeled fatty acid to the precursor and NGS analysis of sex pheromone gland revealed that the sex pheromone component was biosynthesised from a palmitic acid, which existed ubiquitously in the body.