Pathway-specific neuronal modulation by DREADD system in primates
| Project/Area Number |
15H06872
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Basic / Social brain science
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| Research Institution | National Institutes for Quantum and Radiological Science and Technology |
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Principal Investigator |
Fujimoto Atsushi 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所 脳機能イメージング研究部, 博士研究員(任常) (20756390)
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| Project Period (FY) |
2015-08-28 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | サル / DREADD / 基底核 / 意思決定 / 報酬 / 背側線条体 / 腹側淡蒼球 / 線条体 |
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| Outline of Final Research Achievements |
Inhibitory-DREADD (hM4Di) was surgically introduced to the bilateral rostromedial caudate (rmCD) of two monkeys. Systemic infusion of an hM4Di-selective ligand Clozapine-N-Oxide (CNO) reversibly impaired a value-based behavior of the monkeys. Neuronal recordings of the rmCD and the ventral pallidum (VP) revealed strong value coding in these areas, and the faster encoding of predicted reward value in the VP. Our results suggest that the rmCD->VP pathway could facilitate the maintenance of reward information rather than reward prediction itself.
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Report
(3 results)
Research Products
(2 results)
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[Journal Article] PET imaging-guided chemogenetic silencing reveals a critical role of primate rostromedial caudate in reward evaluation.2016
Author(s)
Nagai Y, Kikuchi E, Lerchner W, Inoue Ki, Ji B, Eldridge MA, Kaneko H, Kimura Y, Oh-Nishi A, Hori Y, Kato Y, Hirabayashi T, Fujimoto A, Kumata K, Zhang MR, Aoki I, SuharaT, Higuchi M, Takada M, Richmond BJ, Minamimoto T.
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Journal Title
Nature Communications
Volume: 7
Issue: 1
Pages: 13605-13605
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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