Decoding the genome of the brachiopod Lingula anatina
| Project/Area Number |
15J01101
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| Research Category |
Grant-in-Aid for JSPS Fellows
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| Allocation Type | Single-year Grants |
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| Section | 国内 |
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| Research Field |
Evolutionary biology
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| Research Institution | Okinawa Institute of Science and Technology Graduate University |
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Principal Investigator |
LUO YiーJyun (2017) 沖縄科学技術大学院大学, 科学技術研究科, 特別研究員(DC1)
LUO YIーJYUN (2015-2016) 沖縄科学技術大学院大学, 科学技術研究科, 特別研究員(DC1)
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| Project Period (FY) |
2015-04-24 – 2018-03-31
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| Project Status |
Discontinued (Fiscal Year 2017)
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| Budget Amount *help |
¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 2017: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2016: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2015: ¥900,000 (Direct Cost: ¥900,000)
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| Keywords | Brachiopoda / Phoronida / Nemertea / Lophotrochozoa / Genome / Transcriptome / Evolution / Phylogenomics / Lingula / Brachiopod / Lophotrochozoan / Biomineralization |
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| Outline of Annual Research Achievements |
In the third year, I was focusing on analyzing two new lophotrochozoan genomes, namely a ribbon worm (the nemertean Notospermus geniculatus) and a horseshoe worm (the phoronid Phoronis australis). Based on molecular phylogeny, these two animals are closely related to the brachiopod Lingula anatina. By using comparative genomics, I showed that bilaterian ancestors contained a core set of gene families that are shared by extant deuterostomes and lophotrochozoans. From the transcriptomic analysis, I provided evidence that a conserved bilaterian anterior patterning system is retained in lophotrochozoans.
In addition, I was working on the dorsal-ventral (DV) patterning of Lingula embryos. This project is mainly to understand the evolution of brachiopod body plans and the role of BMP signals in neural induction. BMP signaling is essential in axial patterning and determination of cell fate during early embryogenesis in animals. Interactions between BMP ligands and their antagonists, such as chordin and admp, establish the BMP gradients, which subsequently subdivide the embryos into distinct territories and organize body axes. I provided a functional analysis of DV patterning under the control of BMP signaling in the Lingula embryos. Using small-molecule drugs and recombinant proteins together with deep RNA sequencing, I demonstrated that BMP signaling is required for the folding of mantle lobes along the larval anterior-posterior axis. My findings reveal a conserved function of BMP gradients in brachiopods comparable to that of basal deuterostomes.
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| Research Progress Status |
29年度が最終年度であるため、記入しない。
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| Strategy for Future Research Activity |
29年度が最終年度であるため、記入しない。
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Report
(3 results)
Research Products
(14 results)
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[Presentation] The brachiopod genome of Lingula anatina provides insight into the evolution of lophotrochozoans and calcium-phosphate-based biomineralization2015
Author(s)
Luo YJ, Takeuchi T, Koyanagi R, Yamada L, Kanda M, Khalturina M, Fujie M, Yamasaki S, Endo K, Satoh N
Organizer
Inaugural Meeting of Pan-American Society for Evolutionary Developmental Biology
Place of Presentation
Berkeley, USA
Year and Date
2015-08-05
Related Report
Int'l Joint Research
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[Presentation] The brachiopod genome of Lingula anatina and the evolution of lophotrochozoans and biomineralization2015
Author(s)
Luo YJ, Takeuchi T, Koyanagi R, Yamada L, Kanda M, Khalturina M, Fujie M, Yamasaki S, Endo K, Satoh N
Organizer
The 7th International Brachiopod Congress
Place of Presentation
Nanjing, China
Year and Date
2015-05-23
Related Report
Int'l Joint Research
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[Presentation] The brachiopod genome of Lingula anatina provides insight into the evolution of lophotrochozoans and calcium-phosphate-based biomineralization2015
Author(s)
Luo YJ, Takeuchi T, Koyanagi R, Yamada L, Kanda M, Khalturina M, Fujie M, Yamasaki S, Endo K, Satoh N
Organizer
2015 CSHL Conference on The Biology of Genomes
Place of Presentation
Cold Spring Harbor, USA
Year and Date
2015-05-05
Related Report
