ナノ物質の妊娠期曝露が引き起こす母体炎症応答と胎児への間接影響の評価

• Project/Area Number: 15J05718
• Research Category: Grant-in-Aid for JSPS Fellows
• Allocation Type: Single-year Grants
• Section: 国内
• Research Field: Hygiene and public health
• Research Institution: Tokyo University of Science
• Principal Investigator: 小野田 淳人 東京理科大学, 薬学研究科, 特別研究員(DC1)
• Project Period (FY): 2015-04-24 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,400,000 (Direct Cost: ¥3,400,000); Fiscal Year 2017: ¥1,100,000 (Direct Cost: ¥1,100,000); Fiscal Year 2016: ¥1,100,000 (Direct Cost: ¥1,100,000); Fiscal Year 2015: ¥1,200,000 (Direct Cost: ¥1,200,000)
• Keywords: ナノ粒子 / カーボンブラック / 胎児期暴露 / 中枢神経系 / 血管 / アストロサイト / 小胞体ストレス / 抗酸化剤 / 胎児期曝露 / GFAP / AQP4

Outline of Annual Research Achievements

本研究の目的は、ナノ粒子の胎児期曝露が子の中枢神経系に及ぼす影響とその機序の解明である。最終年度では「ナノ粒子の胎児期曝露により脳血管周辺にβ-sheet rich proteinが集積する要因の解明」を中心的な課題として取り組んだ。β-sheet rich proteinとして、①β-sheet構造を多分に含み、ナノ粒子の胎児期曝露により高発現したタンパク質、②胎児脳に移行したナノ粒子との相互作用により増加したタンパク質の構造変化体 の2つが想定された。網羅的遺伝子発現解析とタンパク質二次構造予測を用いて①の仮説を、脳の老廃物排出機構に基づいて組織学的解析を行うことで②の仮説を検証した。結果、タンパク質の構造変化体の集積によって誘導される小胞体ストレスの脳血管周辺での亢進が認められた。先行研究により、生体内に移行したナノ粒子はタンパク質の二次構造を変化させ、β-sheet構造を増加させること、脳内に存在するタンパク質の構造変化体は血管周辺に集積されることが報告されている。これらの知見と本研究の結果から、ナノ粒子の胎児期曝露は、子の脳血管周辺にタンパク質の構造変化体であるβ-sheet rich proteinを増加・集積させ、脳血管周辺の細胞群に小胞体ストレスやそれに伴う組織学的異変を誘導することが示唆された。この他にも、デンマークとの共同研究によりナノ粒子の妊娠期吸入曝露による子の脳機能への影響とナノ粒子の発達神経毒性に対する抗酸化剤の効果についても更に追究し、論文としてまとめた。以上の成果は、ナノ粒子の胎児期曝露に起因する中枢神経疾患の初期病変を捉えたとともに、その機序の解明に向けた基盤となる知見を提供したものである。本研究で示した知見は、より安全なナノマテリアルの開発や持続可能な利用法の確立に、大気中に浮遊するナノ粒子の健康影響の予測と予防に資するものと期待される。

Research Progress Status

29年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

29年度が最終年度であるため、記入しない。

Research Products

• [Int'l Joint Research] 国立労働衛生研究所/コペンハーゲン大学(デンマーク)
• [Int'l Joint Research] ダマンフール大学/サウスバレー大学(エジプト)
• [Int'l Joint Research] 国立労働衛生研究所(デンマーク)
• [Journal Article] In-ovo exposed carbon black nanoparticles altered mRNA gene transcripts of antioxidants, proinflammatory and apoptotic pathways in the brain of chicken embryo. (2018)
  • Author(s): Samak DH, El-Sayed YS, Shaheen HM, El-Far AH, Onoda A, Abdel-Daim MM, Umezawa M.
  • Journal Title: Chemico-Biological Interactions. Volume: 印刷中 Pages: 133-139
  • DOI: 10.1016/j.cbi.2018.02.031
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Impact of diesel exhaust exposure on the liver of mice fed on omega-3 polyunsaturated fatty acids-deficient diet. (2018)
  • Author(s): Umezawa M, Nakamura M, El-Ghoneimy AA, Onoda A, Shaheen HM, Hori H, Shinkai Y, El-Sayed YS, El-Far AH, Takeda K.
  • Journal Title: Food and Chemical Toxicology. Volume: 111 Pages: 284-294
  • DOI: 10.1016/j.fct.2017.11.027
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Developmental Toxicity of Nanoparticles on the Brain (2017)
  • Author(s): Umezawa M, Onoda A, Takeda K.
  • Journal Title: YAKUGAKU ZASSHI Volume: 137 Issue: 1 Pages: 73-78
  • DOI: 10.1248/yakushi.16-00214
  • NAID: 130005180861
  • ISSN: 0031-6903, 1347-5231
  • Year and Date: 2017-01-01
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Efficacy of α-lipoic acid against cadmium toxicity on metal ion and oxidative imbalance, and expression of metallothionein and antioxidant genes in rabbit brain. (2017)
  • Author(s): Saleh HM, El-Sayed YS, Naser SM, Eltahawy AS, Onoda A, Umezawa M.
  • Journal Title: Environmental Science and Pollution Research. Volume: 24(31) Issue: 31 Pages: 24593-24601
  • DOI: 10.1007/s11356-017-0158-0
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Pretreatment with N-acetyl cysteine suppresses chronic reactive astrogliosis following maternal nanoparticle exposure during gestational period. (2017)
  • Author(s): Onoda A, Takeda K, Umezawa M.
  • Journal Title: Nanotoxicology Volume: 11(8) Issue: 8 Pages: 1012-1025
  • DOI: 10.1080/17435390.2017.1388864
  • Peer Reviewed
• [Journal Article] Perivascular Accumulation of β-Sheet-Rich Proteins in Offspring Brain following Maternal Exposure to Carbon Black Nanoparticles. (2017)
  • Author(s): Onoda A, Kawasaki T, Tsukiyama K, Takeda K, Umezawa M.
  • Journal Title: Frontiers in Cellular Neuroscience. Volume: 11 Pages: 92-92
  • DOI: 10.3389/fncel.2017.00092
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Bioethanol production from waste flying powder (Tobiko), generated in the manufacturing process of Konjac-derived products. (2017)
  • Author(s): Kobayashi K, Saito E, Hirokami K, Hiroi T, Onoda A.
  • Journal Title: Journal of the Japan Institute of Energy. Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Dose-dependent induction of astrocyte activation and reactive astrogliosis in mouse brain following maternal exposure to carbon black nanoparticle. (2017)
  • Author(s): Onoda A, Umezawa M, Takeda K.
  • Journal Title: Particle & Fibre Toxicology. Volume: 14(1) Issue: 1 Pages: 4-4
  • DOI: 10.1186/s12989-017-0184-6
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] [特集] 大気中超微小粒子（ナノ粒子）の健康影響. (2017)
  • Author(s): 梅澤雅和, 立花研, 小野田淳人, 武田健.
  • Journal Title: 環境技術 Volume: 45(11) Pages: 571-576
• [Journal Article] The ceramide inhibitor fumonisin B1 mitigates the pulmonary effects of low-dose diesel exhaust inhalation in mice. (2017)
  • Author(s): Shaheen HM, Onoda A, Shinkai Y, Nakamura M, El-Ghoneimy AA, El-Sayed YS, Takeda K, Umezawa M.
  • Journal Title: Ecotoxicology and Environmental Safety. Volume: 132 Pages: 390-396
  • DOI: 10.1016/j.ecoenv.2016.06.025
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] 超微小粒子の胎児期曝露に伴う脳血管周辺異常の赤外顕微法による可視化. (2017)
  • Author(s): 小野田淳人, 川﨑平康, 築山光一, 武田健, 梅澤雅和.
  • Journal Title: バイオイメージング Volume: 25(1) Pages: 1-1
  • Open Access
• [Journal Article] 動物体内におけるナノ粒子の未知なる動態メカニズムと検出技術改善のニーズ (2017)
  • Author(s): 梅澤雅和, 新海雄介, 小野田淳人, 武田健, 上村真生, 曽我公平.
  • Journal Title: バイオイメージング Volume: 25(1) Pages: 22-27
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Carbon black nanoparticle exposure during middle and late fetal development induces immune activation in male offspring mice (2015)
  • Author(s): El-Sayed YS, Shimizu R, Onoda A, Takeda K, Umezawa M
  • Journal Title: Toxicology Volume: 327 Pages: 53-61
  • DOI: 10.1016/j.tox.2014.11.005
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] カーボンブラックナノ粒子の胎児期曝露により出生児の脳血管周囲病変で誘導される小胞体ストレス (2018)
  • Author(s): 小野田淳人、近藤洋介、宮崎智、武田健、梅澤雅和
  • Organizer: 日本薬学会138年会
• [Presentation] ナノ粒子の妊娠期曝露と次世代健康影響、その予防 (2018)
  • Author(s): 梅澤雅和、小野田淳人、武田健
  • Organizer: 第8回 日本小児禁煙研究会学術集会
  • Invited
• [Presentation] 大気環境と子どもの健康に関する最新の国際動向 －Clean air for children－ (2018)
  • Author(s): 小野田淳人、梅澤雅和
  • Organizer: 日本幼少児健康教育学会第36回大会【春季：朝霞大会】
• [Presentation] 発達期の脳に及ぼすカフェインの影響の網羅的文献調査 (2018)
  • Author(s): 梅澤雅和、小野田淳人
  • Organizer: 日本幼少児健康教育学会第36回大会【春季：朝霞大会】
• [Presentation] ナノ粒子胎児期曝露により出生児の脳に起こるアストログリオーシスの顕微赤外スペクトル法による病態解析 (2017)
  • Author(s): 小野田淳人、川﨑平康、築山光一、武田健、梅澤雅和
  • Organizer: 日本薬学会137年会
  • Place of Presentation: 仙台国際センター（宮城）
  • Year and Date: 2017-03-24
• [Presentation] 大気環境と子どもの脳の発育 (2017)
  • Author(s): 小野田淳人、梅澤雅和
  • Organizer: 日本幼少児健康教育学会第35回大会【春季：世田谷大会】
  • Place of Presentation: 日本体育大学（東京）
  • Year and Date: 2017-03-04
• [Presentation] PM2.5胎児期曝露により出生児の脳に起こるアストログリオーシスの赤外顕微分析 (2017)
  • Author(s): 小野田淳人、梅澤雅和
  • Organizer: FEL-TUS光利用ワークショップ2016
  • Place of Presentation: 東京理科大学（東京）
  • Year and Date: 2017-02-01
• [Presentation] カーボンブラックナノ粒子の妊娠期吸入曝露により児に誘導されるアストログリオーシスと新奇環境下における行動変化 (2017)
  • Author(s): 小野田淳人、Karin S Hougaard、Ulla B Vogel、武田健、梅澤雅和
  • Organizer: フォーラム2017 衛生薬学・環境トキシコロジー
• [Presentation] ナノ粒子の発達神経毒性に対する抗酸化剤の効果 (2017)
  • Author(s): 小野田淳人、武田健、梅澤雅和.
  • Organizer: 第44回日本毒性学会学術年会
• [Presentation] Infrared MicroscopyAnalysis of Brain Perivascular Abnormalities Induced by Maternal Exposure to Carbon Black Nanoparticle. (2017)
  • Author(s): Onoda A, Kawasaki T, Tsukiyama K, Takeda K, Umezawa M
  • Organizer: International Symposium on Imaging Frontier (ISIF 2017)
  • Int'l Joint Research
• [Presentation] Induction of behavioral changes and astrogliosis in the brain of offspring mice following maternal inhalation of carbon black nanoparticle (2017)
  • Author(s): Onoda A, Umezawa M, Takeda K, Jensen COA, Koponen KI, Jensen AK, Vogel U, Hougaard SK
  • Organizer: 8th International Symposium on Nanotechnology, Occupational and Environmental Health (NanOEH 2018)
  • Int'l Joint Research
• [Presentation] Effects of N-acetyl cysteine pretreatment on the long-term astrocyte activation induced by maternal exposure to carbon black nanoparticle in mice. (2016)
  • Author(s): Onoda A, Takeda K, Umezawa M.
  • Organizer: International Conference on Prenatal Programming and Toxicity V (PPTOX V)
  • Place of Presentation: Kitakyushu, Fukuoka (Japan)
  • Year and Date: 2016-11-13
  • Int'l Joint Research
• [Presentation] Effect of maternal exposure to low-dose carbon black nanoparticle on neurobehavior of offspring in mice. (2016)
  • Author(s): Umezawa M, Onoda A, Hagiwara S, Kubota N, Yanagita S, Takeda K.
  • Organizer: International Conference on Prenatal Programming and Toxicity V
  • Place of Presentation: Kitakyushu, Fukuoka (Japan)
  • Year and Date: 2016-11-13
  • Int'l Joint Research
• [Presentation] Effects of antioxidant preadministration on the long-term damage of astrocytes induced by maternal exposure to carbon black nanoparticle in mice. (2016)
  • Author(s): Onoda A, Takeda K, Umezawa M.
  • Organizer: The 11th International Particle Toxicology Conference 2016 (IPTC 2016)
  • Place of Presentation: Singapore (Singapore)
  • Year and Date: 2016-09-26
  • Int'l Joint Research
• [Presentation] Low concentration of nanoparticle-rich diesel exhaust inhalation overexpressed ceramide production in bronchial epithelial cells in mice. (2016)
  • Author(s): Umezawa M, Shaheen HM, Onoda A, El-Sayed YS, Takeda K.
  • Organizer: The 11th International Particle Toxicology Conference 2016 (IPTC 2016)
  • Place of Presentation: Singapore (Singapore)
  • Year and Date: 2016-09-26
  • Int'l Joint Research
• [Presentation] ナノ粒子の胎児期曝露による脳血管周辺異常のin situ赤外顕微スペクトル法を用いた評価 (2016)
  • Author(s): 小野田淳人、川﨑平康、築山光一、武田健、梅澤雅和
  • Organizer: フォーラム2016 衛生薬学・環境トキシコロジー
  • Place of Presentation: 昭和大学（東京）
  • Year and Date: 2016-09-10
• [Presentation] β-Sheetリッチタンパク質の蓄積した脳血管周辺領域における組織学的イメージング (2016)
  • Author(s): 小野田淳人、川﨑平康、築山光一、武田健、梅澤雅和
  • Organizer: 第25回日本バイオイメージング学会
  • Place of Presentation: 名古屋市立大学（愛知）
  • Year and Date: 2016-09-04
• [Presentation] PM2.5にまつわる健康影響の今 (2016)
  • Author(s): 小野田淳人
  • Organizer: 理系フェスティバル2016
  • Place of Presentation: 構造計画研究所（東京）
  • Year and Date: 2016-08-21
  • Invited
• [Presentation] In situ characterization of the brain perivascular abnormalities induced by maternal exposure to nanoparticle using fourier transform infrared microspectroscopy (FT-IR). (2016)
  • Author(s): Onoda A, Kawasaki T, Tsukiyama K, Takeda K, Umezawa M.
  • Organizer: 10th Federation of European Neurosciences Societies Forum of Neuroscience (FENS2016)
  • Place of Presentation: Copenhagen (Denmark)
  • Year and Date: 2016-07-02
  • Int'l Joint Research
• [Presentation] Exosome-like vesicles derived from plants improve the transfer of substances from the nasal cavity to the brain. (2016)
  • Author(s): Umezawa M, Suyama F, Onoda A, Shinkai Y, Tachibana K, Takeda K.
  • Organizer: 10th Federation of European Neurosciences Societies Forum of Neuroscience (FENS2016)
  • Place of Presentation: Copenhagen (Denmark)
  • Year and Date: 2016-07-02
  • Int'l Joint Research
• [Presentation] In situ characterization of the brain perivascular abnormalities induced by maternal exposure to nanoparticle using fourier transform infrared microspectroscopy (FT-IR) (2016)
  • Author(s): Onoda A, Kawasaki T, Tsukiyama K, Takeda K, Umezawa M
  • Organizer: 10th FENS Forum of Neuroscience
  • Place of Presentation: Copenhagen, Denmark
  • Year and Date: 2016-07-02
  • Int'l Joint Research
• [Presentation] Prenatal exposure to carbon black nanoparticle induces protein conformational change in the brain determined by in situ fourier transform infrared spectroscopy (FT-IR). (2016)
  • Author(s): Onoda A, Kawasaki T, Tsukiyama K, Takeda K, Umezawa M.
  • Organizer: The 8th International Conference on Nanotoxicology (Nanotox 2016)
  • Place of Presentation: Boston (U.S.A)
  • Year and Date: 2016-06-01
  • Int'l Joint Research
• [Presentation] Effect of airway exposure to carbon black nanoparticle on the liver of mouse fed with n-3 polyunsaturated fatty acids-deficient diet. (2016)
  • Author(s): Umezawa M, Nakamura M, Hori H, Onoda A, Takeda K.
  • Organizer: The 8th International Conference on Nanotoxicology (Nanotox 2016)
  • Place of Presentation: Boston (U.S.A)
  • Year and Date: 2016-06-01
  • Int'l Joint Research
• [Presentation] Prenatal exposure to carbon black nanoparticle induces protein conformational change in the brain determined by in situ fourier transform infrared spectroscopy (2016)
  • Author(s): Onoda A, Kawasaki T, Tsukiyama K, Takeda K, Umezawa M
  • Organizer: The 8th International Conference on Nanotoxicology, Nanotoxicology 2016
  • Place of Presentation: Boston, Massachusetts, U.S.A.
  • Year and Date: 2016-06-01
  • Int'l Joint Research
• [Presentation] ディーゼル排ガスの低用量曝露が呼吸器系のセラミド代謝に及ぼす影響 (2016)
  • Author(s): 小野田淳人、Hazem M. E. Shaheen、中村仁幸、新海雄介、Ashraf A. El-Ghoneimy、武田健、梅澤雅和
  • Organizer: 日本薬学会 第136年会
  • Place of Presentation: パシフィコ横浜、横浜
  • Year and Date: 2016-03-26
• [Presentation] エクソソーム内包microRNAの脳への輸送 (2016)
  • Author(s): 須山史也、立花研、小野田淳人、武田健、梅澤雅和
  • Organizer: 日本薬学会 第136年会
  • Place of Presentation: パシフィコ横浜、横浜
  • Year and Date: 2016-03-26
• [Presentation] Effect of ascorbic acid pretreatment on brain perivascular injury induced by prenatal exposure to carbon black nanoparticle in mice. (2016)
  • Author(s): Onoda A, Takeda K, Umezawa M
  • Organizer: The Society of Toxicology 55th Annual Meeting (SOT)
  • Place of Presentation: 900 Convention Center Boulevard, New Orleans, Louisiana, U.S.A.
  • Year and Date: 2016-03-13
  • Int'l Joint Research
• [Presentation] Gene expression change in the frontal cortex with perivascular damage induced by prenatal exposure to carbon black nanoparticle in mice. (2016)
  • Author(s): Umezawa M, Onoda A, Takeda K
  • Organizer: The Society of Toxicology 55th Annual Meeting (SOT)
  • Place of Presentation: 900 Convention Center Boulevard, New Orleans, Louisiana, U.S.A.
  • Year and Date: 2016-03-13
  • Int'l Joint Research
• [Presentation] Effect of diesel exhaust exposure on the liver in mouse fed with n-3 polyunsaturated fatty acid-deficient diet (2016)
  • Author(s): Nakamura M, El-Ghoneimy AA, Onoda A, Shinkai Y, Shaheen HM, Takeda K, Umezawa M
  • Organizer: The Society of Toxicology 55th Annual Meeting (SOT)
  • Place of Presentation: 900 Convention Center Boulevard, New Orleans, Louisiana, U.S.A.
  • Year and Date: 2016-03-13
  • Int'l Joint Research
• [Presentation] 脳内の老廃物排出に対する睡眠の効果ならびに出生前環境の関わり (2016)
  • Author(s): 小野田淳人、梅澤雅和
  • Organizer: 日本幼少児健康教育学会第34回大会【春季：青山大会】
  • Place of Presentation: 青山学院大学、東京
  • Year and Date: 2016-03-11
• [Presentation] Nasal-to-brain route as a potential pathway for drug delivery and environmental exposure to nanoparticles (2016)
  • Author(s): Umezawa M, Onoda A, Suyama F, Tachibana K, Takeda K
  • Organizer: 4th International Postgraduate Conference on Pharmaceutical Sciences (iPoPS2016)
  • Place of Presentation: Tokyo university of science, Noda, Chiba, Japan
  • Year and Date: 2016-02-27
  • Int'l Joint Research / Invited
• [Presentation] Nanoparticles-induced oxidative stress and glutathione homeostasis (2016)
  • Author(s): El-Sayed Y, Samak D, Saleh H, Onoda A, Umezawa M, Shaheen H
  • Organizer: 4th International Postgraduate Conference on Pharmaceutical Sciences (iPoPS2016)
  • Place of Presentation: Tokyo university of science, Noda, Chiba, Japan
  • Year and Date: 2016-02-27
  • Int'l Joint Research / Invited
• [Presentation] Diffuse perivascular abnormalities and GFAP and aquaporin-4 dysregulation in the brain induced by maternal exposure to carbon black nanoparticle. [Oral Presentation Award] (2016)
  • Author(s): Onoda A, Takeda K, Umezawa M
  • Organizer: 4th International Postgraduate Conference on Pharmaceutical Sciences (iPoPS2016)
  • Place of Presentation: Tokyo university of science, Noda, Chiba, Japan
  • Year and Date: 2016-02-27
  • Int'l Joint Research
• [Presentation] MicroRNA delivery to the brain by encapsulating with exosomes (2016)
  • Author(s): Suyama F, Tachibana K, Onoda A, Takeda K, Umezawa M
  • Organizer: 4th International Postgraduate Conference on Pharmaceutical Sciences (iPoPS2016)
  • Place of Presentation: Tokyo university of science, Noda, Chiba, Japan
  • Year and Date: 2016-02-27
  • Int'l Joint Research
• [Presentation] Diesel exhaust exposure may exacerbate non-alcoholic fatty liver symptoms in mouse fed n-3 polyunsaturated fatty acids-deficient diet. [Poster Presentation Award] (2016)
  • Author(s): Nakamura M, El-Ghoneimy AA, Onoda A, Shaheen ME, Shinkai Y, Takeda K, Umezawa M
  • Organizer: 4th International Postgraduate Conference on Pharmaceutical Sciences (iPoPS2016)
  • Place of Presentation: Tokyo university of science, Noda, Chiba, Japan
  • Year and Date: 2016-02-27
  • Int'l Joint Research
• [Presentation] Conformation change of albumin incubated with silica nanoparticles determined by infrared spectroscopy (2016)
  • Author(s): Matsuzawa T, Onoda A, Kawasaki T, Tsukiyama K, Takeda K, Umezawa M
  • Organizer: 4th International Postgraduate Conference on Pharmaceutical Sciences (iPoPS2016)
  • Place of Presentation: Tokyo university of science, Noda, Chiba, Japan
  • Year and Date: 2016-02-27
  • Int'l Joint Research
• [Presentation] Oral exposure to silver nanoparticle alters the effect of high-fat diet on perivascular macrophages (2016)
  • Author(s): Hagiwara S, Onoda A, Takeda K, Umezawa M
  • Organizer: 4th International Postgraduate Conference on Pharmaceutical Sciences (iPoPS2016)
  • Place of Presentation: Tokyo university of science, Noda, Chiba, Japan
  • Year and Date: 2016-02-27
  • Int'l Joint Research
• [Presentation] Brain perivascular macrophage, the sensitive target of Nanotoxicology. (2016)
  • Author(s): Onoda A
  • Organizer: Invitation to International Joint Seminar on Environmental toxicity and Mental Health.
  • Place of Presentation: Damanhour, Behera, Egypt
  • Year and Date: 2016-01-13
  • Int'l Joint Research / Invited
• [Presentation] カーボンブラックナノ粒子の胎児期曝露に伴う脳血管周辺異常の赤外顕微分析 (2015)
  • Author(s): 小野田淳人、川﨑平康、築山光一、武田健、梅澤雅和
  • Organizer: 東京理科大学・日本医科大学第2回合同シンポジウム
  • Place of Presentation: 東京理科大学葛飾キャンパス、東京
  • Year and Date: 2015-12-12
• [Presentation] ディーゼル排ガス吸入曝露による呼吸器影響検証を通した疾患の予防・治療標的の探索 (2015)
  • Author(s): 梅澤雅和、李英姫、新海雄介、五月女孝子、平田幸代、稲垣弘文、小野田淳人、SHAHEEN Hazem ME、吾妻安良太、川田智之、武田健
  • Organizer: 東京理科大学・日本医科大学第2回合同シンポジウム
  • Place of Presentation: 東京理科大学葛飾キャンパス、東京
  • Year and Date: 2015-12-12
• [Presentation] シリカナノ粒子によるアルブミン分子構造変化の赤外分光スペクトル解析 (2015)
  • Author(s): 松澤智美、小野田淳人、川崎平康、武田健、梅澤雅和
  • Organizer: 第38回日本分子生物学会年会・第88回生化学会大会合同大会
  • Place of Presentation: 神戸ポートアイランド、神戸
  • Year and Date: 2015-12-01
• [Presentation] 超微小粒子の胎児期曝露に伴う脳血管周辺異常の赤外顕微法による可視化 (2015)
  • Author(s): 小野田淳人、梅澤雅和
  • Organizer: FEL-TUS利用者懇談会
  • Place of Presentation: 東京（ポルタ神楽坂第3会議室）
  • Year and Date: 2015-11-24
• [Presentation] Dysregulation of GFAP and aquapolin-4 proteins of astrocytes in the frontal cortex by prenatal exposure to carbon black nanoparticle. (2015)
  • Author(s): Onoda A, Takeda K, Umezawa M
  • Organizer: 7th International Symposium on Nanotechnology, Occupational and Environmental Health (NanOEH)
  • Place of Presentation: Legend Safari Lodge, Waterberg Region, Limpopo Province, South Africa
  • Year and Date: 2015-10-18
  • Int'l Joint Research
• [Presentation] RT-PCR analysis of the distribution of exosomes with exogenous miRNA to the brain. (2015)
  • Author(s): Suyama F, Tachibana K, Onoda A, Takeda K, Umezawa M
  • Organizer: FENS Featured Regional Meeting 2015
  • Place of Presentation: “Ioannis Vellidis" Congress Center, Thessaloniki, Greece
  • Year and Date: 2015-10-07
  • Int'l Joint Research
• [Presentation] Brain perivascular macrophages decreased by oral exposure to silver nanoparticles and its interaction with high-fat diet in mice. (2015)
  • Author(s): Hagiwara S, Onoda A, Tabata M, Takeda K, Umezawa M
  • Organizer: FENS Featured Regional Meeting 2015
  • Place of Presentation: “Ioannis Vellidis" Congress Center, Thessaloniki, Greece
  • Year and Date: 2015-10-07
  • Int'l Joint Research
• [Presentation] 超微小粒子の胎児期曝露に伴う脳血管周辺異常の赤外顕微法による可視化 [ベストイメージング賞・ニコン賞] (2015)
  • Author(s): 小野田淳人、川﨑平康、築山光一、武田健、梅澤雅和
  • Organizer: 第24回日本バイオイメージング学会
  • Place of Presentation: 東京理科大学葛飾キャンパス、東京
  • Year and Date: 2015-09-26
• [Presentation] ナノ粒子曝露がn-3系多価不飽和脂肪酸欠乏食を摂取したマウスの肝臓に及ぼす影響 (2015)
  • Author(s): 中村仁幸、堀寛、El-Ghoneimy AA、小野田淳人、新海雄介、Shaheen H. ME、武田健、梅澤雅和
  • Organizer: フォーラム2015 衛生薬学・環境トキシコロジー
  • Place of Presentation: 神戸学院大学ポートアイランドキャンパスB号館、神戸
  • Year and Date: 2015-09-17
• [Presentation] ナノ粒子の胎児期曝露が脳血管周囲細胞に及ぼす影響とアスコルビン酸の前投与による効果の検証 (2015)
  • Author(s): 小野田淳人、武田健、梅澤雅和
  • Organizer: フォーラム2015 衛生薬学・環境トキシコロジー
  • Place of Presentation: 神戸学院大学ポートアイランドキャンパスB号館、神戸
  • Year and Date: 2015-09-17
• [Presentation] ディーゼル排ガス曝露が呼吸器のセラミド代謝と遺伝子発現に及ぼす影響 (2015)
  • Author(s): 梅澤雅和、小野田淳人、Shaheen Hazem ME、新海雄介、武田健
  • Organizer: 第56回大気環境学会年会
  • Place of Presentation: 早稲田大学西早稲田キャンパス、東京
  • Year and Date: 2015-09-15
• [Presentation] Detection of inorganic nanoparticles and their potential targets in the brain of mice (2015)
  • Author(s): Umezawa M, Suyama F, Tachibana K, Onoda A, Kubota N, Yanagita S, Takeda K
  • Organizer: 9th World Congress of International Brain Research Organization (IBRO 2015)
  • Place of Presentation: SulAmerica Convention Center, Rio de Janeiro, Brazil
  • Year and Date: 2015-07-07
  • Int'l Joint Research
• [Presentation] ナノ粒子曝露が脳の発達に及ぼす影響―鋭敏なマーカーと毒性学的意義 (2015)
  • Author(s): 梅澤雅和、小野田淳人、川副翔太郎、立花研、武田健
  • Organizer: 第42回日本毒性学会学術年会、シンポジウム：環境化学物質が発達と成熟に及ぼす影響
  • Place of Presentation: ホテル日航金沢、金沢
  • Year and Date: 2015-06-29
  • Invited
• [Presentation] ナノ粒子の胎児期曝露は若齢マウスの脳に老齢個体と類似の慢性所見を誘導する (2015)
  • Author(s): 小野田淳人、菅又昌雄、井原智美、武田健、梅澤雅和
  • Organizer: 第42回日本毒性学会学術年会
  • Place of Presentation: 石川県立音楽堂金沢
  • Year and Date: 2015-06-29
• [Book] Chapter 15: The potential protective effect of antioxidants on nanoparticle toxicity, In: Li YJ et al., editors; "PM2.5 -Role of Oxidative Stress in Health Effects and Prevention Strategy-" (2015)
  • Author(s): Onoda A, Umezawa M, Takeda K
  • Total Pages: 257
  • Publisher: Nova Science Publishers, Inc.
• [Book] Chapter 13: Findings regarding the hazard assessment of nanoparticles and their effects on the next generation, In: Li YJ et al., editors; "PM2.5 -Role of Oxidative Stress in Health Effects and Prevention Strategy-" (2015)
  • Author(s): Umezawa M, Onoda A, Takeda K
  • Total Pages: 257
  • Publisher: Nova Science Publishers, Inc.
• [Remarks] デンマークにおける研究者のワークライフバランス
  • URL: https://www.slideshare.net/atsutoonoda/ss-79539348
• [Remarks] Research map [小野田 淳人]
  • URL: https://researchmap.jp/_atsuto-onoda/
• [Remarks] Image J を用いた組織像の定量解析
  • URL: https://www.slideshare.net/atsutoonoda/image-j-52335489?qid=922034f4-cae3-47f2-ba33-28056fc5d4b0&v=&b=&from_search=1