心血管疾患リスクおよび死亡率の関連因子としての精神ストレス

• Project/Area Number: 15J05980
• Research Category: Grant-in-Aid for JSPS Fellows
• Allocation Type: Single-year Grants
• Section: 国内
• Research Field: Epidemiology and preventive medicine
• Research Institution: The University of Tokyo
• Principal Investigator: SVENSSON THOMAS 東京大学, 医学系研究科, 特別研究員(DC2)
• Project Period (FY): 2015-04-24 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥1,900,000 (Direct Cost: ¥1,900,000); Fiscal Year 2016: ¥900,000 (Direct Cost: ¥900,000); Fiscal Year 2015: ¥1,000,000 (Direct Cost: ¥1,000,000)
• Keywords: Coping / Stress / Cardiovascular disease / Cancer / Epidemiology / Cohort / Incidence / Mortality

Outline of Annual Research Achievements

My research over the past two years has progressed in accordance with the initial timeline defined in my grant application.
The first goal was to investigate the association between stress coping strategies and disease. This has been accomplished and resulted in two publications of which one was considered Editors’Choice. The results of the second article were highlighted by NHK News.
The second goal was to investigate if genetic susceptibility to coronary heart disease modified the effect of stress on cardiovascular disease. The results of this study were presented at the prestigious ESC Congress in Rome, and the manuscript has been accepted for publication in PLOS ONE.
I have also managed additional publications outside the current grant proposal (for details, please see below).

Research Progress Status

28年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

28年度が最終年度であるため、記入しない。

Research Products

• [Int'l Joint Research] Lund University(Sweden)
• [Journal Article] Psychological stress and risk of incident atrial fibrillation in men and women with known atrial fibrillation genetic risk scores (2017)
  • Author(s): Svensson T, Kitlinski M, Engstrom G, Melander O.
  • Journal Title: Scientific Reports Volume: 7 Issue: 1
  • DOI: 10.1038/srep42613
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] A genetic risk score for CAD, psychological stress, and their interaction as predictors of CAD, fatal MI, non-fatal MI and cardiovascular death (2017)
  • Author(s): Svensson T, Kitlinski M, Engstrom G, Melander O.
  • Journal Title: PLOS ONE Volume: -
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Coping strategies and risk of cardiovascular disease incidence and mortality: the Japan Public Health Center-based prospective Study (2016)
  • Author(s): Svensson T, Inoue M, Sawada N, Yamagishi K, Charvat H, Saito I, Kokubo Y, Iso H, Kawamura N, Shibuya K, Mimura M, Tsugane S
  • Journal Title: Eur Heart J Volume: 37 Issue: 11 Pages: 890-899
  • DOI: 10.1093/eurheartj/ehv724
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Coping strategies and cancer incidence and mortality: The Japan Public Health Center-based prospective study (2016)
  • Author(s): Svensson T, Inoue M, Sawada N, Charvat H, Iwasaki M, Sasazuki S, Shimazu T, Yamaji T, Kawamura N, Shibuya K, Mimura M, Tsugane S.
  • Journal Title: Cancer Epidemiology Volume: 40 Pages: 126-133
  • DOI: 10.1016/j.canep.2015.12.003
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Alcohol consumption, genetic variants in the alcohol- and folate metabolic pathways and colorectal cancer risk: the JPHC Study (2016)
  • Author(s): Svensson T, Yamaji T, Budhathoki S, Hidaka A, Iwasaki M, Sawada N, Inoue M, Sasazuki S, Shimazu T, Tsugane S
  • Journal Title: Scientific Reports Volume: 6 Issue: 1 Pages: 36607-36607
  • DOI: 10.1038/srep36607
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Stable Peptide of the Endogenous Opioid Enkephalin Precursor and Breast Cancer Risk (2015)
  • Author(s): Melander O, Orho-Melander M, Manjer J, Svensson T, Almgren P, Nilsson PM, Engstrom G, Hedblad B, Borgquist S, Hartmann O, Struck J, Bergmann A, Belting M.
  • Journal Title: Journal of Clinical Oncology Volume: 33 Issue: 24 Pages: 2632-2638
  • DOI: 10.1200/jco.2014.59.7682
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] The association between complete and partial non-response to psychosocial questions and suicide: the JPHC Study (2015)
  • Author(s): Svensson T, Inoue M, Sawada N, Iwasaki M, Sasazuki S, Shimazu T, Yamaji T, Ikeda A, Kawamura N, Mimura M, Tsugane S
  • Journal Title: European Journal of Public Health Volume: 25 Issue: 3 Pages: 424-430
  • DOI: 10.1093/eurpub/cku209
  • Peer Reviewed / Int'l Joint Research
• [Presentation] Coping strategies and cancer incidence and mortality: The Japan Public Health Center-based prospective study (2016)
  • Author(s): Thomas Svensson
  • Organizer: International Congress of Behavioural Medicine
  • Place of Presentation: Melbourne,Australia
  • Year and Date: 2016-12-08
  • Int'l Joint Research
• [Presentation] Genetic Risk Score, individual genetic variants and psychological stress as predictors of CAD, fatal MI and cardiovascular death (2016)
  • Author(s): Thomas Svensson
  • Organizer: European Society of Cardiology Congress
  • Place of Presentation: Rome,Italy
  • Year and Date: 2016-08-29
  • Int'l Joint Research
• [Remarks] Department of Clinical Sciences
  • URL: http://www.med.lu.se/english/klinvetmalmo/about_the_department
• [Remarks] がんセンター リサーチニュース
  • URL: http://epi.ncc.go.jp/jphc/773/3782.html
• [Remarks] NHK ニュース, 科学文化部ブログ 「 積極的に計画・実行する人"がん死亡リスク低い」
  • URL: http://www9.nhk.or.jp/kabun-blog/200/239184.html