Oscilatory neural circuit calculation wtih excitation / suppression (E / I) balance modulation model in hippocampus
| Project/Area Number |
15K00413
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Life / Health / Medical informatics
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| Research Institution | Tokushima Bunri University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
梶原 利一 明治大学, 理工学部, 専任准教授 (60356772)
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| Co-Investigator(Renkei-kenkyūsha) |
TANEMURA Kentaro 東北大, (連合)農学研究科, 教授 (20332322)
YOSHIMURA Hiroshi 徳島大学, ヘルスバイオサイエンス研究部, 教授 (90288845)
MUTOH Hiroki 浜松医科大学, 医学部, 助教 (60443040)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | E/Iバランス / 海馬 / シータ周期 / ガンマ周期 / 膜電位感受性色素 / バルプロ酸 / 可視化解析 / バルプロ酸モデル / 光学計測 / θ波 / 記憶学習 |
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| Outline of Final Research Achievements |
This study aims to clarify how abnormality of E / I balance causes neuronal circuit information processing abnormality with voltage-sensitive dye (VSD) imaging. The precise activation control of E / I was involved in the short-term plasticity caused by the θ - γ cycle in the hippocampal CA 1 field. The observation was published as a paper in the first year. We have been proceeding with further verification in valproic acid administration model but no significant difference could be found with regard to this short term plasticity phenomenon with respect to this θ - γ cycle. Therefore, we focused on extraction of plastic change caused by this phenomenon and carried out research. I believe that basic data on the relationship of E / I balance disorder have been accumulated.
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Report
(4 results)
Research Products
(35 results)
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[Journal Article] Interplay between non-NMDA and NMDA receptor activation during oscillatory wave propagation: Analyses of caffeine-induced oscillations in the visual cortex of rats2016
Author(s)
Hiroshi Yoshimuraa, b, , , Tokio Sugaib, Nobuo Katob, Takashi Tominagac, Yoko Tominagac, Takahiro Hasegawaa, Chenjuan Yaoa, Tetsuya Akamatsua
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Journal Title
Neural Networks
Volume: 0
Pages: 0-0
DOI
Related Report
Peer Reviewed
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[Journal Article] Reduced Adult Hippocampal Neurogenesis and Cognitive Impairments following Prenatal Treatment of the Antiepileptic Drug Valproic Acid2015
Author(s)
Juliandi B, Tanemura K, Igarashi K, Tominaga T, Furukawa Y, Otsuka M, Moriyama N, Ikegami D, Abematsu M, Sanosaka T, Tsujimura K, Narita M, Kanno J, Nakashima K
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Journal Title
Stem Cell Rep
Volume: 5
Issue: 6
Pages: 996-1009
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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