Elucidation of physiological function of colonic ALP and beta-glucosidase activities, and the effects of food factors on these enzymes
| Project/Area Number |
15K00836
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits
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| Research Institution | Fuji Women's University |
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Principal Investigator |
OKAZAKI Yukako 藤女子大学, 人間生活学部, 准教授 (80433415)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 大腸ALP活性 / ALP遺伝子 / 水溶性食物繊維 / 難消化性オリゴ糖 / 大腸内環境 / ラット / 腸内環境 / β-グルコシダーゼ活性 |
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| Outline of Final Research Achievements |
This study demonstrated that consumption of fermentable non-digestible carbohydrates, including soluble dietary fiber and oligosaccharides, commonly elevated colonic ALP activity by up-regulation of the expression of IAP-I in rats fed a high-fat diet. On the other hand, β-glucosidase activity was not affected by the present dietary manipulation. Colon ALP correlated with colonic luminal variables such as mucins, cecal n-butyrate and fecal ratio of Bifidobacterium spp. that are associated with improvement of colonic environment. These results suggest that the elevating effects of fermentable non-digestible carbohydrates on colonic ALP might be important for protection of gut epithelial homeostasis.
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Report
(4 results)
Research Products
(8 results)
