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Investigation of molecular basis of preventive effects of coffee consumption on lifestyle-related diseases.

Research Project

Project/Area Number 15K00883
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Eating habits
Research InstitutionKeio University

Principal Investigator

TAMURA Hiroomi  慶應義塾大学, 薬学部(芝共立), 教授 (50201629)

Co-Investigator(Kenkyū-buntansha) 多胡 めぐみ  慶應義塾大学, 薬学部(芝共立), 准教授 (30445192)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsコーヒー / 生活習慣病 / 予防薬学 / 糖尿病 / 抗炎症 / 肥満 / IRS1 / Nrf2 / 焙煎 / 認知症 / 白内障 / 炎症 / 大腸がん
Outline of Final Research Achievements

It has been reported that habitual coffee intake reduces the risk of developing lifestyle-related diseases associated with obesity and inflammation. We found that the coffee bean roasting ingredient suppresses the differentiation of adipocytes, a risk factor of obesity, by promoting the degradation of the adapter molecule IRS1 of the insulin signaling pathway, using the preadipocyte 3T3-L1 . Regarding the anti-inflammatory effect of coffee, we found that the coffee bean roasting ingredient suppresses the inflammatory response of LPS-induced mouse macrophage cells, and the effect was due to the activation of the transcription factor Nrf2 by promoting the degradation of Keap1. The above results lead to the elucidation of the effect of prevention of lifestyle diseases caused by drinking of coffee on the molecular bases.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (35 results)

All 2018 2017 2016 2015 Other

All Journal Article (10 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 10 results,  Open Access: 7 results,  Acknowledgement Compliant: 6 results) Presentation (20 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results) Book (1 results) Remarks (4 results)

  • [Journal Article] Administration of antioxidant compounds affects the lens chaperone activity and prevents the onset of cataracts.2017

    • Author(s)
      Nakazawa Y, Nagai N, Ishimori N, Oguchi J, Tamura H.
    • Journal Title

      Biomed Pharmacother.

      Volume: 95 Pages: 137-143

    • DOI

      10.1016/j.biopha.2017.08.055

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Coffee extract inhibits adipogenesis in 3T3-L1 preadipocyes by interrupting insulin signaling through the downregulation of IRS12017

    • Author(s)
      Maki C, Funakoshi-Tago M, Aoyagi R, Ueda F, Kimura M, Kobata K, Tago K, Tamura H
    • Journal Title

      PLoS One

      Volume: 12(3) Issue: 3 Pages: e0173264-e0173264

    • DOI

      10.1371/journal.pone.0173264

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Coffee reduces KRAS expression in Caco-2 human colon carcinoma cells via regulation of miRNAs.2017

    • Author(s)
      Nakayama T, Funakoshi-Tago M, Tamura H.
    • Journal Title

      Oncol Lett.

      Volume: 14 Issue: 1 Pages: 1109-1114

    • DOI

      10.3892/ol.2017.6227

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhances the Anti-Cataract Effect of Coffee Beans: Ameliorating Selenite-Induced Cataracts in Rats.2017

    • Author(s)
      Ishimori N, Oguchi J, Nakazawa Y, Kobata K, Funakoshi-Tago M, Tamura H
    • Journal Title

      Current Eye Research

      Volume: - Issue: 6 Pages: 864-870

    • DOI

      10.1080/02713683.2016.1262877

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Roasted coffee induces aldo-keto reductase 1C3 (AKR1C3) expression in human prostate cancer LNCaP cells associated with Nrf2 activation.2016

    • Author(s)
      Kuniji Takahashi, Megumi Funakoshi-Tago, Marie Takaoka, Shota Kakio, Kenji Kobata, and Hiroomi Tamura
    • Journal Title

      Oncology Letters

      Volume: -

    • DOI

      10.3892/ol.2016.5334

    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Coffee induces vascular endothelial growth factor (VEGF) expression in human neuroblastama SH-SY5Y cells.2016

    • Author(s)
      Shota Kakio, Megumi Funakoshi-Tago, Kenji Kobata and Hiroomi Tamura
    • Journal Title

      Nutritional Neuroscience

      Volume: - Issue: 6 Pages: 336-342

    • DOI

      10.1080/1028415x.2015.1133106

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A proline type fullerene derivative inhibits adipogenesis by preventing PPARgamma activation.2016

    • Author(s)
      Megumi Funakoshi-Tago, Takahiro Hattori, Fumihito Ueda, Kenji Tago, Tomoyuki Ohe, Tadahiko Mashino and Hiroomi Tamura
    • Journal Title

      Biochemistry and Biophysics Reports

      Volume: 5 Pages: 259-265

    • DOI

      10.1016/j.bbrep.2016.01.001

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Coffee modulates the function of brain-derived neurotrophic factor (BDNF) in human neuroblastoma SH-SY5Y cells.2015

    • Author(s)
      Shota Kakio, Yosuke Nakazawa, Megumi Funakoshi-Tago and Hiroomi Tamura
    • Journal Title

      Neuroscience & Medicine

      Volume: 6 Issue: 04 Pages: 165-174

    • DOI

      10.4236/nm.2015.64025

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Nepetaefuran and leonotinin isolated from Leonotis nepetaefolia R. Br. potently inhibit the LPS signaling pathway by suppressing the transactivation of NF-κB.2015

    • Author(s)
      eda F, Iizuka K, Tago K, Narukawa Y, Kiuchi F, Kasahara T, Tamura H, Funakoshi-Tago M.
    • Journal Title

      Int Immunopharmacol

      Volume: 28 Issue: 2 Pages: 967-976

    • DOI

      10.1016/j.intimp.2015.08.015

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Anti-inflammatory activity of flavonoids in Nepalese propolis is attributed to inhibition of the IL-33 signaling pathway.2015

    • Author(s)
      Funakoshi-Tago M, Okamoto K, Izumi R, Tago K, Yanagisawa K, Narukawa Y, Kiuchi F, Kasahara T, Tamura H.
    • Journal Title

      Int Immunopharmacol

      Volume: 25 Pages: 189-198

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] コーヒーによる肥満誘導白内障予防効果の検討2018

    • Author(s)
      鈴木正太、中澤洋介、福山和也、石森奈奈、小口潤、多胡めぐみ、田村悦臣
    • Organizer
      日本薬学会第138年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 抗炎症作用を示すコーヒー含有成分の同定及びその作用機序の解析2017

    • Author(s)
      松髙 茉里、並木 淳裕、古旗 賢二、多胡 めぐみ、田村 悦臣
    • Organizer
      平成29年度日本生化学会関東支部例会
    • Related Report
      2017 Annual Research Report
  • [Presentation] MCF-7 細胞におけるエストロゲン受容体の発現に対するコーヒーの影響2017

    • Author(s)
      李チン、多胡めぐみ、中澤洋介、田村悦臣
    • Organizer
      第61回日本薬学会関東支部大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] コーヒーは神経芽細胞腫においてプロテアソームを活性化することによってBACE1のタンパク発現を抑制する2017

    • Author(s)
      福山和也、垣尾将太、古旗賢二、鈴木利治、多胡めぐみ、田村悦臣
    • Organizer
      2017年度生命科学系学会合同年次大会(ConBio2017)
    • Related Report
      2017 Annual Research Report
  • [Presentation] Coffee reduces BACE1 expression by activation of proteasomal degradation in human neuroblastoma SH-SY5Y cells.2017

    • Author(s)
      K. Fukuyama, S. Kakio, K. Kobata, T. Suzuki, M. Tago, H. Tamura
    • Organizer
      第60回日本神経化学会(仙台)大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] コーヒー成分によるヒト神経芽細胞腫におけるβ-セクレターゼ発現の抑制効果.2016

    • Author(s)
      福山和也, 垣尾将大, 古旗賢二, 鈴木利治, 多胡めぐみ, 田村悦臣
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      東北大学(宮城県仙台市)
    • Year and Date
      2016-09-26
    • Related Report
      2016 Research-status Report
  • [Presentation] 抗炎症作用を示すコーヒー含有成分の解析2016

    • Author(s)
      松髙茉里, 上田史仁, 古旗賢二, 中澤洋介, 多胡めぐみ, 田村悦臣
    • Organizer
      第60回日本薬学会関東支部大会
    • Place of Presentation
      東京大学(東京都文京区)
    • Year and Date
      2016-09-21
    • Related Report
      2016 Research-status Report
  • [Presentation] 白内障効果をもつコーヒー成分の解析.2016

    • Author(s)
      小口潤, 石森奈奈, 中澤洋介, 多胡めぐみ, 田村悦臣
    • Organizer
      第60回日本薬学会関東支部大会
    • Place of Presentation
      東京大学(東京都文京区)
    • Year and Date
      2016-09-21
    • Related Report
      2016 Research-status Report
  • [Presentation] Coffee reduces KRAS expression in Caco-2 human colon carcinoma cells via regulation of miRNA.2016

    • Author(s)
      Tamura H. Nakayama T, Funakoshi-Tago M.
    • Organizer
      ESPEN 2016
    • Place of Presentation
      Copenhagen(Denmark)
    • Year and Date
      2016-09-20
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] コーヒーによる白内障抑制効果の検討2016

    • Author(s)
      田村悦臣、中澤洋介、石森奈奈、小口潤、多胡めぐみ
    • Organizer
      第42回水晶体研究会
    • Place of Presentation
      いわて県民情報交流センター アイ―ナ(岩手県盛岡市)
    • Year and Date
      2016-07-31
    • Related Report
      2016 Research-status Report
  • [Presentation] コーヒーによる白内障抑制効果の検討2016

    • Author(s)
      石森奈奈、中澤洋介、多胡めぐみ、岡美佳子、竹鼻眞、田村悦臣
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-03-29
    • Related Report
      2015 Research-status Report
  • [Presentation] コーヒー豆抽出液が示す抗炎症作用の検討2016

    • Author(s)
      谷尾真由美、野中勇佑、多胡めぐみ、田村悦臣
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-03-29
    • Related Report
      2015 Research-status Report
  • [Presentation] ヒト結腸がん細胞のK-ras発現に対するコーヒーの効果2015

    • Author(s)
      中山拓哉、八木利恭、多胡(船越)めぐみ、田村悦臣
    • Organizer
      第88回日本生化学会大会
    • Place of Presentation
      神戸ポートアイランド(兵庫県神戸市)
    • Year and Date
      2015-12-02
    • Related Report
      2015 Research-status Report
  • [Presentation] ヒト神経芽細胞腫SH-SY5Yにおける血管内皮増殖因子VEGF発現に対するコーヒーの影響2015

    • Author(s)
      垣尾翔大、古旗賢二、多胡めぐみ、田村悦臣
    • Organizer
      第88回日本生化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-01
    • Related Report
      2015 Research-status Report
  • [Presentation] ヒト神経芽細胞腫SH-SY5YにおけるBACE1発現に対するコーヒーの効果2015

    • Author(s)
      福山和也、垣尾翔大、古旗賢二、鈴木利治、多胡めぐみ、田村悦臣
    • Organizer
      第88回日本生化学会大会
    • Place of Presentation
      神戸ポートアイランド(兵庫県神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Research-status Report
  • [Presentation] コーヒーによる認知症予防効果の分子基盤の解析2015

    • Author(s)
      田村悦臣
    • Organizer
      第5回日本認知症予防学会
    • Place of Presentation
      神戸国際会議場(兵庫県神戸市)
    • Year and Date
      2015-09-27
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] SH-SY5Y細胞における血管内皮増殖因子VEGFの発現に対するコーヒーの影響2015

    • Author(s)
      垣尾翔大、榎崇一郎、古旗賢二、多胡めぐみ、田村悦臣
    • Organizer
      第5回日本認知症予防学会
    • Place of Presentation
      神戸国際会議場(兵庫県神戸市)
    • Year and Date
      2015-09-25
    • Related Report
      2015 Research-status Report
  • [Presentation] Coffee reduces BACE1 expression in human neuroblastoma SH-SY5Y cells.2015

    • Author(s)
      Kazuya Fukuyama, Shota Kakio, Soichiro Enoki, Kenji Kobata, Toshiharu Suzauki, Megumi Funakoshi-Tago, Hiroomi Tamura.
    • Organizer
      第58回日本神経化学会(大宮)大会
    • Place of Presentation
      大宮ソニックシティー(埼玉県大宮市)
    • Year and Date
      2015-09-13
    • Related Report
      2015 Research-status Report
  • [Presentation] Effects of coffee on vascular endothelial growth factor expression in human neuroblastoma SH-SY5Y cells2015

    • Author(s)
      Shota Kakio, Soichiro Enoki, Kenji Kobata, Megumi Funakoshi-Tago, Hiroomi Tamura.
    • Organizer
      第58回日本神経化学会(大宮)大会
    • Place of Presentation
      大宮ソニックシティー(埼玉県大宮市)
    • Year and Date
      2015-09-12
    • Related Report
      2015 Research-status Report
  • [Presentation] Coffee induces vascular endothelial growth factor expression in human neuroblastoma SH-SY5Y cells2015

    • Author(s)
      Shota Kakio, Soichiro Enoki, Kenji Kobata, Megumi Funakoshi-Tago, Hiroomi Tamura
    • Organizer
      25th Meeting of the International Society for Neurochemistry
    • Place of Presentation
      Cains (Australia)
    • Year and Date
      2015-08-25
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Book] Chapter 61. Effects of Coffee on Estrogen Sulfation in Human Colon Carcinoma Caco-2 Cells. in "Coffee in health and Disease Prevention"2015

    • Author(s)
      Hiroomi Tamura (ed. V. Preedy)
    • Total Pages
      8
    • Publisher
      Academic Press
    • Related Report
      2015 Research-status Report
  • [Remarks] 慶応義塾大学薬学研究科衛生化学講座紹介

    • URL

      http://www.pha.keio.ac.jp/research/hc/index.html

    • Related Report
      2017 Annual Research Report
  • [Remarks] 研究室紹介

    • URL

      http://www.pha.keio.ac.jp/research/hc/index.html

    • Related Report
      2016 Research-status Report 2015 Research-status Report
  • [Remarks] 食と医科学フォーラム

    • URL

      http://foodscience.keio.ac.jp/profile-tamura/

    • Related Report
      2016 Research-status Report 2015 Research-status Report
  • [Remarks] 週刊朝日記事より

    • URL

      http://dot.asahi.com/wa/2013110700024.html

    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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