| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Collagen and Elastin are structural proteins of the dermis and are closely related to the tissue properties. It is known that ultraviolet rays decrease proteins such as elastin in the dermis. However, the biomechanical contribution of elastin to the skin properties remains unknown. The purpose of the present study was to determine whether the external medication of elastin ingredients is effective for the maintenance and improvement of the skin extensibility. Specifically, we studied the enhanced healing efficacy for ultraviolet damage by the application of an ointment involved elastin ingredients. The results obtained indicate that the stiffening or hardening of skin tissues due to the ultraviolet irradiation is presumably suppressed by the elastin application to skin tissues. Moreover, the elastin application possibly prevents the acanthosis of skin tissues due to the ultraviolet irradiation.
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