Interaction between gut microbiota and food-derived compounds for prevention and control of cardiovascular endothelial dysfunction
| Project/Area Number |
15K01717
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | The University of Tokushima |
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Principal Investigator |
MAWATARI Kazuaki 徳島大学, 大学院医歯薬学研究部(医学系), 講師 (40352372)
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| Co-Investigator(Kenkyū-buntansha) |
下畑 隆明 徳島大学, 大学院医歯薬学研究部(医学系), 助教 (90609687)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 腸内マイクロバイオーム / 血管内皮細胞 / 腸内微生物叢 / 血管内皮機能 |
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| Outline of Final Research Achievements |
Vascular endothelial cells have important roles in homeostasis of cardiovascular system. Aims of this study were to observe gut microbiota in early-stage atherosclerosis animal model, to search food-derived compounds those induce endothelium-dependent vasodilation, and to investigate effects of these compounds on gut microbiota.
Intima-thickened aorta and decrease of endothelium-dependent vasodilation were observed in high fat diet (HFD)-fed C57BL/6 mice By phylum-specific quantitative polymerase chain reaction (qPCR) for monitoring gut microbiota, HFD-fed mice had higher Firmicutes bacteria than normal diet-fed mice, but did not change Bacteroidetes bacteria. And we found that some food-derived polyphenols had activity of endothelium-dependent vasodilation, but couldn't check any effect of those on gut microbiota.
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Report
(4 results)
Research Products
(7 results)
