Studies on heart-bound adiponectin for heart disease suppression and therapeutic effect
Project/Area Number |
15K01734
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Applied health science
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Research Institution | Kindai University |
Principal Investigator |
INOUE Takao 近畿大学, 医学部, 助教 (00441006)
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Co-Investigator(Kenkyū-buntansha) |
竹森 久美子 近畿大学, 農学部, 准教授 (00288888)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 臓器結合型アディポネクチン / 心肥大 / 高血圧 / 心筋結合型アディポネクチン / 血清アディポネクチン / T-cadherin / 心筋細胞肥大 / 心筋線維化 / 心疾患 |
Outline of Final Research Achievements |
Researches on adiponectin have been focused on the relationship between adiponectin in blood and diseases. These researches show that adiponectin in blood and diseases have inverse correlation because adiponectin is anti-metabolic syndrome hormone. Recently, we discovered organ-bound adiponectin as a novel adiponectin. We assessed the relationship between heart-bound adiponectin and hypertension or cardiac hypertrophy. The result showed that heart-bound adiponectin, but not serum adiponectin, inversely correlated with cardiac hypertrophy. Further analysis of gene expression in heart showed that there are genes might be involved in hypertension and cardiac hypertrophy via heart-bound adiponectin.
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] Increased ectodomain shedding of cell adhesion molecule 1 as a cause of type II alveolar epithelial cell apoptosis in patients with idiopathic interstitial pneumonia.2015
Author(s)
2.Yoneshige, A., Hagiyama, M., Inoue, T., Mimae, T., Kato, T., Okada, M., Enoki, E., Ito, A.
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Journal Title
Respir. Res.
Volume: 16
Issue: 1
Pages: 90-90
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] The intracellular domain of cell adhesion molecule 1 is present in emphysematous lungs and induces lung epithelial cell apoptosis.2015
Author(s)
1.Hagiyama, M., Yoneshige, A., Inoue, T., Sato, Y., Mimae, T., Okada, M., Ito, A.
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Journal Title
J. Biomed. Sci
Volume: 22
Issue: 1
Pages: 67-67
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Heart-bound adiponectin, not serum adiponectin, correlates with cardiac hypertrophy in stroke-prone spontaneously hypertensive rats.2016
Author(s)
Inoue, T., Takemori, K., Mizuguchi, N., Kimura, M., Chikugo, T., Hagiyama, M., Yoneshige, A. Mori, T., Kometani, T., Itoh, T., Satou, T., and Ito, A.
Organizer
The 26th Scientific Meeting of the International Society of Hypertension.
Place of Presentation
Seoul, Korea
Year and Date
2016-09-24
Related Report
Int'l Joint Research
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