Isolation and biological activity of marine natural compounds with bone-resorbing and bone forming properties
| Project/Area Number |
15K01803
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biomolecular chemistry
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| Research Institution | University of the Ryukyus |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
Woo Je-Tae 中部大学, 応用生物学部・応用生物科学科 (20272693)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 破骨細胞 / 骨芽細胞 / アルカリホスファターゼ / 海洋ラン藻 / アルカリ性ホスファターゼ / 石灰化 / 海洋シアノバクテリア / リポペプチド |
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| Outline of Final Research Achievements |
Two new pyrrolinone-containing lipopeptides, ypaoamides B and C, were isolated from an Okeania sp. marine cyanobacterium collected in Okinawa. Their structures were determined by spectroscopic analysis and Marfey’s analysis of acid hydrolysates. Ypaoamides C inhibited receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclastogenesis in mouse monocytic RAW264 cells. Aplysin is a known compound derived from Red Alga Laurencia nidifica collected in Okinawa. Aplysin enhanced the Alkaline Phosphatase (ALP) activity, an early osteoblast marker.
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Report
(4 results)
Research Products
(22 results)
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[Journal Article] Leptolyngbyolides, Cytotoxic Macrolides from the Marine Cyanobacterium Leptolyngbya sp.: Isolation, Biological Activity, and Catalytic Asymmetric Total Synthesis2017
Author(s)
Cui, J.; Morita, M.; Ohno, O.; Kimura, T.; Teruya, T.; Watanabe, T.; Suenaga, K.; Shibasaki, M.
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Journal Title
Chem. Eur. J.
Volume: 23
Issue: 35
Pages: 8500-8509
DOI
Related Report
Peer Reviewed
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[Journal Article] Biseokeaniamides A, B, and C, Sterol O-Acyltransferase Inhibitors from an Okeania sp. Marine Cyanobacterium.2017
Author(s)
Iwasaki A, Tadenuma T, Sumimoto S, Ohshiro T, Ozaki K, Kobayashi K, Teruya T, Tomoda H, Suenaga K.
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Journal Title
J Nat Prod.
Volume: 80
Issue: 4
Pages: 1161-1166
DOI
Related Report
Peer Reviewed
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[Journal Article] Antiproliferative Activity of Acerogenin C, a Macrocyclicdiarylheptanoid, on PDGF-Induced Human Aortic Smooth Muscle Cells Proliferation2015
Author(s)
Byung-Yoon Cha, Wen Lei Shi, Kotaro Watanabe, Takayuki Yonezawa, Toshiaki Teruya, Kiyotake Kiyotake, Yuichi Ishikawa, Shigeru Nishiyama, Kazuo Nagai, Je-Tae Woo
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Journal Title
Pharmacology & Pharmacy
Volume: 6
Issue: 02
Pages: 47-55
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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