Size-Controlled and Biocompatible Paramagnetic Nanoparticles for Dual Photoacoustic and MR Imaging
| Project/Area Number |
15K01819
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical biology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
木村 祐 京都大学, 健康長寿社会の総合医療開発ユニット, 特定准教授 (90566027)
山田 久嗣 徳島大学, 大学院社会産業理工学研究部(生物資源産業学域), 講師 (80512764)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 光超音波イメージング / 磁気共鳴イメージング / 常磁性金属酸化物 / ナノ粒子 / 分子プローブ / 造影剤 / 抗癌剤 / セラノスティック / HER2 完全長抗体 / ゼラチン / 常磁性金属 / マンガン酸化物 / 糖 / 生体適合性 |
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| Outline of Final Research Achievements |
One of the most rapidly developing and exciting applications of nanotechnology in biomedical research is the development of biocompatible nanoparticles (NPs) for use in multiple powerful and highly complementary imaging modalities.Gd-based inorganic nanoparticles such as Gd2O3 have recently been investigated as potential positive contrast agents in magnetic resonance imaging (MRI). However, our main goal is to synthesize and isolate new size-controlled and biocompatible paramagnetic metal oxide NPs, Gd2O3 and MnO, as a bimodal contrast agent for use in photoacoustic (PA) and MR imaging through the fusion of inorganic NPs and organic materials.
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Report
(4 results)
Research Products
(25 results)
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[Journal Article] Magnetic resonance imaging of tumor with a self-traceable phosphorylcholine polymer2015
Author(s)
Hisatsugu Yamada, Yoshinori Hasegawa, Hirohiko Imai, Yuki Takayama, Fuminori Sugihara, Tetsuya Matsuda, Hidehito Tochio, Masahiro Shirakawa, Shinsuke Sando, Yu Kimura, Akio Toshimitsu, Yasuhiro Aoyama and Teruyuki Kondo
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Journal Title
Journal of the American Chemical Society
Volume: 137
Issue: 2
Pages: 799-806
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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