Research Project
Grant-in-Aid for Scientific Research (C)
For 220 ELBW children at school age, 9.5% of the subjects were classified as intellectual disability (ID); 9.1% as having borderline intelligence; 23.2% as LD; 15.9% as ASD; 20.5% as ADHD. IVH increased the risk for lower IQs, higher ASSQ scores, and lower nonverbal PRS scores. Grade 3 or 4 IVH was also associated with inattention. Children suffering from CLD showed the lower IQ and PIQ. ROP was associated with lower PIQ. Among these perinatal complications, severe IVH might be the most important risk factor of ASD. The relative contribution of genetic and environmental influences to developmental disorders were assessed for 45 same gender twin pairs: 24 were MZ and 21 were DZ pairs. While parameters of genetic influences were higher on Hyperactivity-Impulsivity, Ones of shared environmental influences were higher on ASSQ and Inattention.These findings indicate that the shared environment has relatively larger influences on incidence of ASD and Inattention for ELBW children.
学齢期の極・超低出生体重児にASD、LD、ADHDなどの発達障害様の症状が高率で認められた。発達障害様症状の発症には脳室内出血、慢性肺疾患などの周産期合併症が影響を与えていることが示された。さらに、一卵性双胎と二卵性双胎の比較により遺伝率よりは共有環境の寄与率が高いことが示され、発症メカニズムに周産期の環境要因が関係している可能性が確認された。ASDは遺伝的な要因が優勢とされるが、通常とは異なり周産期因子が後生的に作用している可能性が強まった。周産期合併症に関しては周産期医学の進歩により今後その医学的予防や医学的治療が可能になれば極・超低出生体重児の発達障害様症状の軽減につながるかもしれない。
All 2018 2017 2016 2015
All Journal Article (11 results) (of which Peer Reviewed: 8 results, Open Access: 5 results) Presentation (40 results) (of which Int'l Joint Research: 8 results, Invited: 3 results) Book (1 results)
コミュニケーション障害学
Volume: 35 Pages: 1-10
40021577416
Early Human Development
Volume: 128 Pages: 6-11
10.1016/j.earlhumdev.2018.10.008
特殊教育学研究
Volume: 55
130007616521
Journal of Special Education Research
Volume: 6 Issue: 1 Pages: 1-9
10.6033/specialeducation.6.1
130006406374
Journal of Educational and Developmental Psychology
Volume: 7 Issue: 2 Pages: 33-42
10.5539/jedp.v7n2p33
言語聴覚研究
Volume: 13 Pages: 68-76
40020895662
Volume: 印刷中
Acta Paediatrica
Volume: 104(2) Issue: 2 Pages: e82-e89
10.1111/apa.12854
Archives of Disease in Childhood: Fetal and Neonatal Edition.
Volume: 0 Issue: 4 Pages: F314-F319
10.1136/archdischild-2014-306931
Volume: 32 Pages: 109-115
40020586805
International Journal of Psychology and Behavioral Sciences
Volume: 5 Pages: 62-70
