Specificity and etiologic mechanism of developmental disorders-like symptoms for extremely low birth weight children.
| Project/Area Number |
15K04061
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Educational psychology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Research Collaborator |
ISAKI Motohiro
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| Project Period (FY) |
2015-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 超低出生体重児 / 学齢期 / 発達障害様症状 / 発症メカニズム / 周産期合併症 / 共有環境 / 周産期因子 / 合併症 / 注意機能 / 読みの障害 / 実行機能 / エピジェネティクス / 読み能力 |
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| Outline of Final Research Achievements |
For 220 ELBW children at school age, 9.5% of the subjects were classified as intellectual disability (ID); 9.1% as having borderline intelligence; 23.2% as LD; 15.9% as ASD; 20.5% as ADHD. IVH increased the risk for lower IQs, higher ASSQ scores, and lower nonverbal PRS scores. Grade 3 or 4 IVH was also associated with inattention. Children suffering from CLD showed the lower IQ and PIQ. ROP was associated with lower PIQ. Among these perinatal complications, severe IVH might be the most important risk factor of ASD. The relative contribution of genetic and environmental influences to developmental disorders were assessed for 45 same gender twin pairs: 24 were MZ and 21 were DZ pairs. While parameters of genetic influences were higher on Hyperactivity-Impulsivity, Ones of shared environmental influences were higher on ASSQ and Inattention.These findings indicate that the shared environment has relatively larger influences on incidence of ASD and Inattention for ELBW children.
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| Academic Significance and Societal Importance of the Research Achievements |
学齢期の極・超低出生体重児にASD、LD、ADHDなどの発達障害様の症状が高率で認められた。発達障害様症状の発症には脳室内出血、慢性肺疾患などの周産期合併症が影響を与えていることが示された。さらに、一卵性双胎と二卵性双胎の比較により遺伝率よりは共有環境の寄与率が高いことが示され、発症メカニズムに周産期の環境要因が関係している可能性が確認された。ASDは遺伝的な要因が優勢とされるが、通常とは異なり周産期因子が後生的に作用している可能性が強まった。周産期合併症に関しては周産期医学の進歩により今後その医学的予防や医学的治療が可能になれば極・超低出生体重児の発達障害様症状の軽減につながるかもしれない。
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Report
(5 results)
Research Products
(52 results)
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[Journal Article] Physical fitness of non-disabled school-aged children born with extremely low birth weights.2018
Author(s)
Tamai, K., Nishihara, M., Hirata, K., Shiraishi, J., Hirano, S., Fujimura, M., Yano, S., Kanazawa, T., & Kitajima, H.
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Journal Title
Early Human Development
Volume: 128
Pages: 6-11
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Long-term alpha-tocopherol supplements may improve mental development in extremely low birthweight infants.2015
Author(s)
Kitajima, H., Kanazawa, T., Mori, R., Hirano, S., Ogihara, T., & Fujimura, M.
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Journal Title
Acta Paediatrica
Volume: 104(2)
Issue: 2
Pages: e82-e89
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Perinatal factors associated with long-term respiratory sequelae in extremely low birthweight infants.2015
Author(s)
Hirata, K., Nishihara, M., Shiraishi, J., Hirano, S., Matsunami, K., Sumi, K., Wada, N., Kawamoto, Y., Nishikawa, M., Nakayama, M., Kanazawa, T., Kitajima, H., & Fujimura, M.
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Journal Title
Archives of Disease in Childhood: Fetal and Neonatal Edition.
Volume: 0
Issue: 4
Pages: F314-F319
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Eye movements during dyadic interactions among very low birth weight children.2015
Author(s)
Isaki1, M., Kanazawa, T., Kamada, J., Hinobayashi, T., & Kitajima, H.
Organizer
17th European Conference on Developmental Psychology
Place of Presentation
Braga, Portugal
Year and Date
2015-09-08
Related Report
Int'l Joint Research
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