Obsessive-Compulsive Disorder in Adults with Autism Spectrum Disorders Comorbidity : Examining Neuropsychological Features

• Project/Area Number: 15K04115
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Clinical psychology
• Research Institution: Chiba University
• Principal Investigator: Miyata Haruko 千葉大学, 子どものこころの発達教育研究センター, 特任研究員 (20749478)
• Co-Investigator(Kenkyū-buntansha): 平野 好幸 千葉大学, 子どものこころの発達教育研究センター, 特任教授 (50386843) ; 浅野 憲一 千葉大学, 子どものこころの発達教育研究センター, 特任助教 (60583432) ; 大島 郁葉 千葉大学, 子どものこころの発達教育研究センター, 特任助教 (40625472)
• Co-Investigator(Renkei-kenkyūsha): NAKAGAWA Akiko 千葉大学, 子どものこころの発達教育研究センター, 特任教授 (70253424)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 神経心理検査 / 臨床心理学 / 認知機能

Outline of Final Research Achievements

This study tries to investigate OCD with ASD comorbidity to find its neuropsychological features by conducting various neuropsychological tests. Participants with a primary diagnosis of OCD but not ASD. After conducting ASD trait assessments, the participants were divided into the following three groups: OCD with no ASD comorbidity [OCD (ASD－)] (n=22), OCD with ASD comorbidity [OCD (ASD+)] (n=13). The study examined the three groups comparisons with [OCD (ASD－) and OCD (ASD+) and Healthy Controls (HCs) (n=29)] by using various neuropsychological tests.
There was no significant difference among the groups in executive function. However, the findings revealed that individuals with OCD (ASD+) had lower cognitive processing speeds and the two OCD groups are similar in certain cognitive abilities, as reflected by lower processing speeds. However, different factors might affect their overall performance in the two groups.

Research Products

• [Journal Article] Obsessive-Compulsive Disorder in Adults with Autism Spectrum Disorders Comorbidity: Examining Neuropsychological Features (2018)
  • Author(s): 宮田 はる子
  • Journal Title: 法政大学大学院人間社会研究科博士論文 Volume: １ Pages: １－95
  • Peer Reviewed / Open Access
• [Journal Article] Relationship between symptom dimensions and brain morphology in obsessive-compulsive disorder (2017)
  • Author(s): Hirose M, Hirano Y, Nemoto K, Sutoh C, Asano K, Miyata H, Matsumoto J, Nakazato M, Matsumoto K, Masuda Y, Iyo M, Shimizu E, Nakagawa A.
  • Journal Title: Brain Imaging Behav Volume: 11 Pages: 1326-1333
  • DOI: 10.1007/s11682-016-9611-9
  • Peer Reviewed
• [Journal Article] Relationship between symptom dimensions and white matter alterations in OCD (2017)
  • Author(s): Yagi M, Hirano Y, Nakazato M, Nemoto K, Ishikawa K, Sutoh C, Miyata H, Matsumoto J, Matsumoto K, Masuda Y, Obata T, Iyo M, Shimizu E, Nakagawa A.
  • Journal Title: Acta Neuropsychiatrica Volume: 印刷中 Pages: 印刷中
  • DOI: 10.1017/neu.2016.45.
  • Peer Reviewed
• [Journal Article] Relationship between symptom dimensions and brain morphology in obsessive-compulsive disorder (2017)
  • Author(s): Hirose M, Hirano Y, Nemoto K, Sutoh C, Asano K, Miyata H, Matsumoto J, Nakazato M, Matsumoto K, Masuda Y, Iyo M, Shimizu E, Nakagawa A.
  • Journal Title: Brain Imaging and Behavior Volume: 印刷中 Pages: 印刷中
  • DOI: 10.1007/s11682-016-9611-9.
  • Peer Reviewed
• [Journal Article] 自閉症スペクトラム障害を併存する成人の強迫性障害の患者の認知機能の特徴： ウェクスラー知能検査による検証 (2016)
  • Author(s): 宮田 はる子
  • Journal Title: 法政大学大学院紀要 Volume: 77号 Pages: 117-125
  • Open Access
• [Journal Article] Correlation between morphologic changes and autism spectrum tendency in obsessive-compulsive disorder (2015)
  • Author(s): Kobayashi T, Hirano Y, Nemoto K, Sutoh C, Ishikawa K, Miyata H, Matsumoto J, Matsumoto K, Masuda Y, Nakazato M, Shimizu E, Nakagawa A
  • Journal Title: Magn Reson Med Sci Volume: 14 Pages: 329-35
  • DOI: 10.2463/mrms.2014-0146
  • Peer Reviewed / Int'l Joint Research
• [Presentation] Do neuropsychological tests give a clue for ASD tendency in adult OCD patients? (2016)
  • Author(s): Haruko Miyata, Yoshiyuki Hirano, Fumiyo Oshima, Kenichi Asano, Junko Matsumoto, Maki Nagaoka, Haruka Koike, Eiji Shimizu, Akiko Nakagawa
  • Organizer: the 46th European Association of Behabioural and Cognitive Therapies Congress
  • Place of Presentation: Stockholm (Sweden)
  • Year and Date: 2016-09-01
  • Int'l Joint Research
• [Presentation] Clinical Predictors of Response to Cognitive Behabioural Treatment for OCD with and without ASD (2016)
  • Author(s): Aki Tsuchiyagaito, Fumiyo Oshima, Ken-ichi Asano, Sawako Nagaoka, Haruko Miyata, Masaru Kunou, Yoshiyuki Hirano, Eiji Shimizu, Akiko Nakagawa
  • Organizer: the 8th World Congress of Behavioural and Cognitive Therapies
  • Place of Presentation: Melbourne (Australia)
  • Year and Date: 2016-06-22 – 2016-06-25
  • Int'l Joint Research
• [Presentation] 強迫症患者における自 閉スペクトラム症の併存と認知行動療法の効果 (2016)
  • Author(s): 土屋垣内晶、浅野憲一、大島郁葉、永岡紗和子、宮田はる子、松本淳子、大城恵子、永岡麻貴、久能勝、平野好幸、清水栄司、中川彰子
  • Organizer: 第8回日本不安症学会学術大会
  • Place of Presentation: 千葉大学亥鼻キャンパス（千葉県千葉市）
  • Year and Date: 2016-02-06 – 2016-02-07
• [Presentation] 強迫性障害における自閉傾向と脳の 形態学的変化との関連 (2016)
  • Author(s): 小林智子、平野好幸、根本清貴、須藤千尋、宮田はる子、松本淳子、松本浩史、桝田喜正、中里道子、清水栄司、中川彰子
  • Organizer: 第8回日本不安症学会学術大会
  • Place of Presentation: 千葉大学亥鼻キャンパス（千葉県千葉市）
  • Year and Date: 2016-02-06 – 2016-02-07
• [Presentation] 強迫症における症状ディメンジョンと脳灰白質 体積との関連 (2016)
  • Author(s): 廣瀬素久、平野好幸、浅野憲一、松本淳子、宮田はる子、須藤千尋、中里道子、根本清貴、清水栄司、中川彰子
  • Organizer: 第8回日本不安症学会学術大会
  • Place of Presentation: 千葉大学亥鼻キャンパス（千葉県千葉市）
  • Year and Date: 2016-02-06 – 2016-02-07