| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Outline of Final Research Achievements |
Organofluorine compounds have increased their importance as pharmaceuticals and agrochemicals especially in recent years. We have focused our attention on difluorocarbene complexes that realize highly efficient syntheses of organofluorine compounds with metal catalysts. It was disclosed that nickel(II) and copper(I) complexes generate the corresponding difluorocarbene complexes and that selective syntheses of isomeric α,α- and β,β-difluorocyclopentanone derivatives, starting from common silyl dienol ethers, were facilitated. The structures which we successfully constructed in this project were commonly found in those of biologically active compounds, leading to development and efficient manufacturing of pharmaceuticals and agrochemicals in future.
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