Development of asymmetric catalyst directed to dynamic reaction field control based on bisamidine framework
| Project/Area Number |
15K05506
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Synthetic chemistry
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| Research Institution | Rikkyo University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 不斉触媒 / 触媒設計 / 立体選択性 / DFT計算 / ビスアミジン / 不斉合成 / ビスアミジン配位子 / ルイス酸 / 水素結合 / 分子認識 / Friedel-Craftsアルキル化反応 / インドール |
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| Outline of Final Research Achievements |
To achieve high efficiency and low environmental load required for modern asymmetric catalysts, we developed an asymmetric catalyst directed to "dynamic reaction field control", in which different asymmetric reaction fields are controlled depending on catalyst preparation conditions, achieving chemoselective and stereoselective asymmetric reactions. DFT calculations clarified major factors of high selectivities based on combined-acid function and hydrogen bonding network. Specifically, chiral bisamidine ligands were developed as a key framework incorporating different catalytic functions. Selectively preparaed combined-acid catalysts or multinuclear-metal catalysts were employed to various asymmetric reactions.
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Report
(4 results)
Research Products
(44 results)
