| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Functionalized cycloalkenes having hydrophilic functional groups [e.g, (2-methoxyethoxy)carbonyl, hydroxyl] were synthesized and polymerized by Grubbs catalyst to expand the scope of Ring-opening metathesis polymerization (ROMP). A variety of functional groups were successfully introduced and the ROMP of monomers were proceeded in a regioselective manner to afford novel polycycloalkenamers possessing precisely placed side-chain branches. Hydration water structure in the obtained polymers was analyzed by using DSC measurement, revealed that the amount of intermediate water was increased with the increase of side chain density and molecular mobility. The blood-compatibility of obtained polymers was investigated and the number of adhered platelets was decreased with increasing the amount of intermediate water. This result is indicating that blood-compatibility of polymer materials can be controlled by tuning the chemical structure of polymers.
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