Evaluation study of antioxidative abilities of the keto-carotenoid species found in photosynthetic bacteria

• Project/Area Number: 15K05577
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Bio-related chemistry
• Research Institution: Kurume University
• Principal Investigator: Harada Jiro 久留米大学, 医学部, 講師 (10373094)
• Co-Investigator(Kenkyū-buntansha): 山本 健 久留米大学, 医学部, 教授 (60274528) ; 溝口 正 立命館大学, 総合科学技術研究機構, 教授 (90343665) ; 佐藤 秀明 久留米大学, 医学部, 准教授 (60271996)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 応用微生物 / 生体分子 / 生体機能利用 / 薬理学 / メタボリックシンドローム / 微生物応用 / 糖尿病

Outline of Final Research Achievements

Metabolic syndrome developed from the oxidative stress-induced adiposity is the risk factors for myocardial and cerebral infarctions, and it is imperative that its prophylaxis is exploited. In this study, it is evaluated that photosynthetic bacterial carotenoids known as antioxidants, are effective for prevention of metabolic syndrome.

Research Products

• [Journal Article] In vitro enzymatic assays of photosynthetic bacterial 3-vinyl hydratases for bacteriochlorophyll biosyntheses (2018)
  • Author(s): Teramura Misato、Harada Jiro、Tamiaki Hitoshi
  • Journal Title: Photosynthesis Research Volume: 135 Issue: 1-3 Pages: 319-328
  • DOI: 10.1007/s11120-017-0415-6
  • Peer Reviewed / Open Access
• [Journal Article] In vivo energy transfer from bacteriochlorophyll c, d, e, or f to bacteriochlorophyll a in the wild-type and mutant cells of the green sulfur bacterium Chlorobaculum limnaeum (2018)
  • Author(s): J. Harada, Y. Shibata, M. Teramura, T. Mizoguchi, Y. Kinoshita, K. Yamamoto, H. Tamiaki
  • Journal Title: ChemPhotoChem Volume: 2 Issue: 3 Pages: 190-195
  • DOI: 10.1002/cptc.201700164
  • Peer Reviewed / Open Access
• [Journal Article] DNA methylation of the Klf14 gene region in whole blood cells provides prediction for the chronic inflammation in the adipose tissue (2018)
  • Author(s): Iwaya Chihiro、Kitajima Hidetoshi、Yamamoto Ken、Maeda Yasutaka、Sonoda Noriyuki、Shibata Hiroki、Inoguchi Toyoshi
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 497 Issue: 3 Pages: 908-915
  • DOI: 10.1016/j.bbrc.2017.12.104
  • Peer Reviewed / Open Access
• [Journal Article] Light-dependent accumulation of new bacteriochlorophyll-e bearing a vinyl group at the 8-position in the green sulfur bacterium Chlorobaculum limnaeum (2018)
  • Author(s): T. Mizoguchi, Y. Kinoshita, J. Harada, S. Ogasawara, H. Tamiaki
  • Journal Title: J. Photochem. Photobiol. A: Chem. Volume: 358 Pages: 356-361
  • DOI: 10.1016/j.jphotochem.2017.08.071
  • Peer Reviewed
• [Journal Article] Genome-wide DNA methylation analysis reveals hypomethylation in the low-CpG promoter regions in lymphoblastoid cell lines. (2017)
  • Author(s): Taniguchi I, Iwaya C, Ohnaka K, Shibata H, Yamamoto K
  • Journal Title: Human Genomics Volume: 11 Issue: 1 Pages: 8-8
  • DOI: 10.1186/s40246-017-0106-6
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Epigenome-wide association of myocardial infarction with DNA methylation sites at loci related to cardiovascular disease. (2017)
  • Author(s): Nakatochi M, Ichihara S, Yamamoto K, Naruse K, Yokota S, Asano H, Matsubara T, Yokota M.
  • Journal Title: Clin. Epigenetics Volume: 9 Issue: 1 Pages: 54-54
  • DOI: 10.1186/s13148-017-0353-3
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Protein-Truncating Variants at the Cholesteryl Ester Transfer Protein Gene and Risk for Coronary Heart Disease. (2017)
  • Author(s): Nomura A, Tada H, Kawashiri MA, Inazu A, Yamagishi M, Rader DJ, Kathiresan S, et al.
  • Journal Title: Circ Res. Volume: 121 Issue: 1 Pages: 81-88
  • DOI: 10.1161/circresaha.117.311145
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Molecular Structures and Functions of Chlorophylls-a Esterified with Geranylgeranyl, Dihydrogeranylgeranyl, and Tetrahydrogeranylgeranyl Groups at the 17-Propionate Residue in a Diatom, Chaetoceros calcitrans. (2017)
  • Author(s): Mizoguchi T, Isaji M, Yamano N, Harada J, Fujii R, Tamiaki H
  • Journal Title: Biochemistry Volume: 56 Issue: 28 Pages: 3682-3688
  • DOI: 10.1021/acs.biochem.7b00381
  • Peer Reviewed
• [Journal Article] Multiple common and rare variants of ABCG2 cause gout (2017)
  • Author(s): Higashino Toshihide、Takada Tappei、Nakaoka Hirofumi、Toyoda Yu、Stiburkova Blanka、Miyata Hiroshi、Ikebuchi Yuki、Nakashima Hiroshi、Shimizu Seiko、Kawaguchi Makoto、Sakiyama Masayuki、Nakayama Akiyoshi、Akashi Airi、Tanahashi Yuki、Kawamura Yusuke、Nakamura Takahiro、Wakai Kenji、Hosomichi Kazuyoshi 他
  • Journal Title: RMD Open Volume: 3 Issue: 2 Pages: e000464-e000464
  • DOI: 10.1136/rmdopen-2017-000464
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The fine-scale genetic structure and evolution of the Japanese population (2017)
  • Author(s): Fumihiko Takeuchi, Tomohiro Katsuya, Ryosuke Kimura, Toru Nabika, Minoru Isomura, Takayoshi Ohkubo, Yasuharu Tabara, Ken Yamamoto, Mitsuhiro Yokota, Xuanyao Liu, Woei-Yuh Saw, Dolikun Mamatyusupu, Wenjun Yang, Shuhua Xu, Japanese Genome Variation Consortium, YikYing Teo, Norihiro Kato
  • Journal Title: PLoS One Volume: 12 Issue: 11 Pages: e0185487-e0185487
  • DOI: 10.1371/journal.pone.0185487
  • NAID: 120006892744
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Japanese genome-wide association study identifies a significant colorectal cancer susceptibility locus at chromosome 10p14. (2017)
  • Author(s): Takahashi Y, Sugimachi K, Yamamoto K, Niida A, Shimamura T, Sato T, Watanabe M, Tanaka J, Kudo S, Sugihara K, Hase K, Kusunoki M, Yamada K, Shimada Y, Moriya Y, Suzuki Y, Miyano S, Mori M, Mimori K
  • Journal Title: Cancer Sci. Volume: 108(11) Issue: 11 Pages: 2239-2247
  • DOI: 10.1111/cas.13391
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Genome-wide DNA methylation analysis reveals hypomethylation in the low-CpG promoter regions in lymphoblastoid cell lines (2017)
  • Author(s): Taniguchi I, Iwaya C, Ohnaka K, Shibata H, Yamamoto K
  • Journal Title: Human Genomics Volume: xx
  • Peer Reviewed
• [Journal Article] Epigenomewide association of myocardial infarction with DNA methylation sites at loci related to cardiovascular disease (2017)
  • Author(s): Nakatochi M, Ichihara S, Yamamoto K, Naruse K, Yokota S, Asano H, Matsubara T, Yokota M
  • Journal Title: Clinical Epigenetics Volume: xx
  • Peer Reviewed
• [Journal Article] GWAS of clinically defined gout and subtypes identifies multiple susceptibility loci that include urate transporter genes. (2017)
  • Author(s): Nakayama A, Nakaoka H, Yamamoto K, Sakiyama M, Shaukat A, Toyoda Y, Okada Y, Ohkawa Y,他39名
  • Journal Title: Ann Rheum Dis. Volume: 76 Issue: 5 Pages: 869-877
  • DOI: 10.1136/annrheumdis-2016-209632
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Characterising private and shared signatures of positive selection in 37 Asian populations (2017)
  • Author(s): Liu X, Lu D, Saw WY, Shaw PJ, Wangkumhang P, Ngamphiw C, Fucharoen S, Lert-Itthiporn W, Chin-Inmanu K, Chau TN, Anders K, Kasturiratne A, de Silva HJ, Katsuya T, Kimura R, Nabika T, Ohkubo T, Tabara Y, Takeuchi F, Yamamoto K, 他16名
  • Journal Title: European Journal of Human Genetics Volume: 25 Issue: 9 Pages: 499-508
  • DOI: 10.1038/ejhg.2016.18
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Significant association of RNF213 p.R4810K, a moyamoya susceptibility variant, with coronary artery disease (2017)
  • Author(s): Morimoto T, Mineharu Y, Ono K, Nakatochi M, Ichihara S, Kabata R, Takagi Y, Cao Y, Zhao L, Kobayashi H, Harada K. H, Takenaka K, Funaki T, Yokota M, Matsubara T, Yamamoto K, Izawa H, Kimura T, Miyamoto S, Koizumi A
  • Journal Title: PLoS ONE Volume: 12 Issue: 4 Pages: e0175649-e0175649
  • DOI: 10.1371/journal.pone.0175649
  • NAID: 120006534994
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] A substrate-bound structure of cyanobacterial biliverdin reductase identifies stacked substrates as critical for activity (2017)
  • Author(s): Haruna Takao, Kei Hirabayashi, Yuki Nishigaya, Haruna Kouriki, Tetsuko Nakaniwa, Yoshinori Hagiwara, Jiro Harada, Hideaki Sato, Toshimasa Yamazaki, Yoichi Sakakibara, Masahito Suiko, Yujiro Asada, Yasuhiro Takahashi, Ken Yamamoto, Keiichi Fukuyama, Masakazu Sugishima, and Kei Wada
  • Journal Title: Nat. Commun. Volume: 8 Issue: 1 Pages: 1-10
  • DOI: 10.1038/ncomms14397
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A Japanese family with autosomal dominant oculocutaneous albinism type4. (2017)
  • Author(s): Oki R, Yamada K, Nakano S, Kimoto K, Yamamoto K, Kondo H, Kubota T.
  • Journal Title: Invest Ophthalmol Vis Sci. Volume: 58 Issue: 2 Pages: 1008-1016
  • DOI: 10.1167/iovs.16-20612
  • Peer Reviewed / Open Access
• [Journal Article] Biochemical characterization of rhamnosyltransferase involved in biosynthesis of pectic rhamnogalacturonan I in plant cell wall (2017)
  • Author(s): Uehara Y, Tamura S, Maki Y, Yagyu K, Mizoguchi T, Tamiaki H, Imai T, Ishii T, Ohashi T, Fujiyama K, Ishimizu T
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 486 Issue: 1 Pages: 130-136
  • DOI: 10.1016/j.bbrc.2017.03.012
  • Peer Reviewed
• [Journal Article] Biosynthesis of Unnatural Glycolipids Possessing Diyne Moiety in the Acyl Chain in the Green Sulfur Photosynthetic Bacterium Chlorobaculum tepidum Grown by Supplementation of 10,12-Heptadecadiynic Acid (2017)
  • Author(s): 佐賀佳央、吉田望見、山田翔大、溝口正、民秋均
  • Journal Title: Biochemistry and Biophysics Reports Volume: 9 Pages: 42-46
  • DOI: 10.1016/j.bbrep.2016.11.007
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Organo-gelation of natural bacteriochlorophyll-c in carbon tetrachloride: dependence upon the stereochemistry at the 31-position and the alkyl substituents at the 8-position (2017)
  • Author(s): T. Mizoguchi, Y. Kinoshita, J. Harada, H. Tamiaki
  • Journal Title: ChemPlusChem Volume: 82 Issue: 4 Pages: 595-597
  • DOI: 10.1002/cplu.201600494
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] A microfluidic-based protein crystallization method in 10 micrometer-sized crystallization space (2016)
  • Author(s): Maeki M, Yamazaki S, Pawate SA, Ishida A, Tani H, Yamashita K, Sugishima M, Watanabe K, Tokeshi M, Kenis PJA, Miyazaki M
  • Journal Title: CrystEngComm Volume: 18 Issue: 40 Pages: 7722-7727
  • DOI: 10.1039/c6ce01671e
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Atomic-resolution structure of the phycocyanobilin:ferredoxin oxidoreductase I86D mutant in complex with fully protonated biliverdin (2016)
  • Author(s): Hagiwara Y, Wada K, Irikawa T, Sato H, Unno M, Yamamoto K, Fukuyama K, Sugishima M
  • Journal Title: FEBS Letters Volume: 590 Issue: 19 Pages: 3425-3434
  • DOI: 10.1002/1873-3468.12387
  • Peer Reviewed / Open Access
• [Journal Article] Identification of rs671, a common variant of ALDH2, as a gout susceptibility locus. (2016)
  • Author(s): M. Sakiyama, H. Matsuo, H. Nakaoka, K. Yamamoto, A. Nakayama, T. Nakamura, S. Kawai, R. Okada, H. Ooyama, T. Shimizu, and N. Shinomiya
  • Journal Title: Scientific Reports Volume: 6 Issue: 1 Pages: 25360-25360
  • DOI: 10.1038/srep25360
  • Peer Reviewed / Open Access
• [Journal Article] In vitro assays of BciC showing C13^2-demethoxycarbonylase activity requisite for biosynthesis of chlorosomal chlorophyll pigments. (2016)
  • Author(s): M. Teramura, J. Harada, T. Mizoguchi, K. Yamamoto, and H. Tamiaki
  • Journal Title: Plant & Cell Physiology Volume: xx Issue: 5 Pages: 1048-1057
  • DOI: 10.1093/pcp/pcw045
  • Peer Reviewed
• [Journal Article] Genomic Landscape of Esophageal Squamous Cell Carcinoma in a Japanese Population. (2016)
  • Author(s): G. Sawada (他43名, 山本21番目)
  • Journal Title: Gastroenterology Volume: 150 Issue: 5 Pages: 1171-1182
  • DOI: 10.1053/j.gastro.2016.01.035
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] In vitro stereospecific hydration activities of the 3-vinyl group of chlorophyll derivatives by BchF and BchV enzymes involved in bacteriochlorophyll c biosynthesis of green sulfur bacteria. (2016)
  • Author(s): M. Teramura, J. Harada, and H. Tamiaki
  • Journal Title: Photosynthesis Research Volume: xx Issue: 1-3 Pages: 33-45
  • DOI: 10.1007/s11120-016-0220-7
  • Peer Reviewed
• [Journal Article] Glycolipid analyses of light-harvesting chlorosomes from envelope protein mutants of Chlorobaculum tepidum (2016)
  • Author(s): Y. Tsukatani, T. Mizoguchi, J. Thweatt, M. Tank, D. A. Bryant, H. Tamiaki
  • Journal Title: Photosynth. Res. Volume: 128 Issue: 3 Pages: 235-241
  • DOI: 10.1007/s11120-016-0228-z
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Understanding of HLA-conferred susceptibility to chronic hepatitis B infection requires HLA genotyping-based association analysis. (2016)
  • Author(s): N. Nishida (他37名, 山本31番目)
  • Journal Title: Scientific Reports Volume: 6 Issue: 1 Pages: 24767-24767
  • DOI: 10.1038/srep24767
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Stereoselective self-aggregation of 3^1-epimerically pure amino analogs of zinc bacteriochlorophyll-d in an aqueous micelle solution (2016)
  • Author(s): H. Watanabe, T. Mizoguchi and H. Tamiaki
  • Journal Title: Photochemistry and Photobiology Volume: 92 Issue: 2 Pages: 276-285
  • DOI: 10.1111/php.12562
  • Peer Reviewed
• [Journal Article] Genome-wide association studies in East Asians identify new loci for waist-hip ratio and waist circumference. (2016)
  • Author(s): W. Wen (他75名, 山本55番目)
  • Journal Title: Scientific Reports Volume: 6 Issue: 1 Pages: 17958-17958
  • DOI: 10.1038/srep17958
  • NAID: 120005822753
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Novel exonic mutation inducing aberrant splicing in the IL10RA gene and resulting in infantile-onset inflammatory bowel disease: a case report. (2016)
  • Author(s): T. Yanagi, T. Mizuochi, Y. Takaki, K. Eda, K. Mitsuyama, M. Ishimura, H. Takada, D. S. Shouval, A. E. Griffith, S. B. Snapper, Y. Yamashita, and K. Yamamoto
  • Journal Title: BMC Gastroenterology Volume: 16 Issue: 1 Pages: 10-10
  • DOI: 10.1186/s12876-016-0424-5
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Integrated Multiregional Analysis Proposing a New Model of Colorectal Cancer Evolution. (2016)
  • Author(s): R. Uchi (他40名, 山本36番目)
  • Journal Title: PLoS Genetics Volume: 12 Issue: 2 Pages: 1-24
  • DOI: 10.1371/journal.pgen.1005778
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] In vitro self-assemblies of bacteriochlorophylls-c from Chlorobaculum tepidum and their supramolecular nanostructures. (2016)
  • Author(s): S. Shoji, T. Mizoguchi and H. Tamiaki
  • Journal Title: Journal of Photochemistry and Photobiology A: Chemistry Volume: xx Pages: 190-196
  • DOI: 10.1016/j.jphotochem.2015.11.003
  • Peer Reviewed
• [Journal Article] Glycolipid analyses in envelope protein mutants of light-harvesting chlorosomes of Chlorobaculum tepidum. (2016)
  • Author(s): Y. Tsukatani, T. Mizoguchi, J. Thweatt, M. Tank, D. A. Bryant and H. Tamiaki
  • Journal Title: Photosynthesis Research Volume: xx
  • Peer Reviewed
• [Journal Article] Genome-wide association study of clinically defined gout identifies multiple risk loci and its association with clinical subtypes. (2015)
  • Author(s): Matsuo H, et al.
  • Journal Title: Ann Rheum Dis. Volume: 印刷中 Issue: 4 Pages: 652-659
  • DOI: 10.1136/annrheumdis-2014-206191
  • Peer Reviewed / Open Access
• [Journal Article] Rhodobacter sphaeroides mutants overexpressing chlorophyllide a oxidoreductase of Blastochloris viridis elucidate functions of enzymes in late bacteriochlorophyll biosynthetic pathways (2015)
  • Author(s): Y. Tsukatani, J. Harada, J. Nomata, H. Yamamoto, Y. Fujita, T. Mizoguchi, H. Tamiaki
  • Journal Title: Sci. Rep. Volume: 5 Issue: 1 Pages: 9741-9741
  • DOI: 10.1038/srep09741
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] In vitro enzymatic activities of bacteriochlorophyll a synthase derived from the green sulfur photosynthetic bacterium Chlorobaculum tepidum. (2015)
  • Author(s): Y. Saga, Y. Hirota, J. Harada, and H. Tamiaki
  • Journal Title: Biochemistry Volume: 54 Issue: 32 Pages: 4998-5005
  • DOI: 10.1021/acs.biochem.5b00311
  • Peer Reviewed
• [Journal Article] Complete genome sequence of the bacteriochlorophyll b-producing photosynthetic bacterium Blastochloris viridis. (2015)
  • Author(s): Y. Tsukatani, Y. Hirose, J. Harada, N. Misawa, K. Mori, K. Inoue, and H. Tamiaki
  • Journal Title: Genome Announcements Volume: 3 Issue: 5
  • DOI: 10.1128/genomea.01006-15
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Modification of the esterifying farnesyl chain in light-harvesting bacteriochlorophylls in green sulfur photosynthetic bacteria by supplementation of 9-decyn-1-ol, 9-decen-1-ol, and decan-1-ol. (2015)
  • Author(s): Y. Saga, K. Hayashi, K. Hirota, J. Harada, and H. Tamiaki
  • Journal Title: Journal of Photochemistry and Photobiology A: Chemistry Volume: 313 Pages: 44-51
  • DOI: 10.1016/j.jphotochem.2015.05.002
  • Peer Reviewed
• [Journal Article] Inactivation of bciD and bchU genes in the green sulfur bacterium Chlorobaculum limnaeum and alteration of photosynthetic pigments in the resultant mutants. (2015)
  • Author(s): T. Mizoguchi, J. Harada, K. Yamamoto, and H. Tamiaki
  • Journal Title: Journal of Photochemistry and Photobiology A: Chemistry Volume: 313 Pages: 52-59
  • DOI: 10.1016/j.jphotochem.2015.06.012
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Stereochemiacl conversion of C3-vinyl group to 1-hydroxyethyl group in bacteriochlorophyll c by the hydratases BchF and BchV: adaptation of green sulfur bacteria to limited-light environments. (2015)
  • Author(s): J. Harada, M. Teramura, T. Mizoguchi, Y. Tsukatani, K. Yamamoto, and H. Tamiaki
  • Journal Title: Molecular Microbiology Volume: 98 Issue: 6 Pages: 1184-1198
  • DOI: 10.1111/mmi.13208
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] 光合成細菌の脂質. (2015)
  • Author(s): 塚谷祐介、民秋 均、溝口 正
  • Journal Title: 光合成研究 Volume: 25 Pages: 151-159
  • Peer Reviewed
• [Journal Article] Submicroscopic deletions at 13q32.1 cause congenital microcoria (2015)
  • Author(s): Fares-Taie, L. Gerber, S. Tawara, A. Ramirez-Miranda, A. Douet, J. Y. Verdin, H. Guilloux, A. Zenteno, J. C. Kondo, H. Moisset, H. Passet, B. Yamamoto, K. Iwai, M. Tanaka, T. Nakamura, Y. Kimura, W. Bole-Feysot, C. Vilotte, M. Odent, S. Vilotte, J. L. Munnich, A. Regnier, A. Chassaing, N. et al.
  • Journal Title: Am J Hum Genet Volume: 96 Issue: 4 Pages: 631-9
  • DOI: 10.1016/j.ajhg.2015.01.014
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• [Journal Article] β2-glycoprotein I/ HLA class II complexes are novel autoantigens in antiphospholipid syndrome. (2015)
  • Author(s): Tanimura K, Jin H, Suenaga T, Morikami S, Arase N, Kishida K, Hirayasu K, Kohyama M, Ebina Y, Yasuda S, Horita T, Takasugi K, Ohmura K, Yamamoto K, Katayama I, Sasazuki T, Lanier LL, Atsumi T, Yamada H, Arase H.
  • Journal Title: Blood Volume: 125 Issue: 18 Pages: 2835-2844
  • DOI: 10.1182/blood-2014-08-593624
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• [Journal Article] A novel missense mutation of RYR1 in familial idiopathic hyper CK-emia. (2015)
  • Author(s): K. Sano, S. Miura, T. Fujiwara, R. Fujioka, A. Yorita, K. Noda, H. Kida, K. Azuma, S. Kaieda, K. Yamamoto, T. Taniwaki, Y. Fukumaki, and H. Shibata
  • Journal Title: Journal of the Neurological Sciences Volume: 356 Issue: 1-2 Pages: 142-147
  • DOI: 10.1016/j.jns.2015.06.035
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• [Journal Article] Japan Multiple Sclerosis Genetics Consortium Copy Number Variations in Multiple Sclerosis and Neuromyelitis Optica. (2015)
  • Author(s): S. Sato, K. Yamamoto, T. Matsushita, N. Isobe, Y. Kawano, K, Iinuma, M. Niino, T. Fukazawa, Y. Nakamura, M. Watanabe, T. Yonekawa, K. Masaki, S. Yoshimura, H. Murai, R. Yamasaki, J. Kira
  • Journal Title: Annals of Neurology Volume: 78 Issue: 5 Pages: 762-774
  • DOI: 10.1002/ana.24511
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• [Journal Article] Trans-ethnic genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation. (2015)
  • Author(s): N. Kato (他104名, 山本63番目)
  • Journal Title: nature genetics Volume: 47 Issue: 11 Pages: 1282-1293
  • DOI: 10.1038/ng.3405
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• [Journal Article] Epigenome-wide association study suggests that SNPs in the promoter region of RETN influence plasma resistin level via effects on DNA methylation at neighbouring sites. (2015)
  • Author(s): M. Nakatochi, S. Ichihara, K. Yamamoto, K. Ohnaka, Y. Kato, S. Yokota, A. Hirashiki, K. Naruse, H, Asano, H. Izawa, T. Matsubara, and M. Yokota
  • Journal Title: Diabetologia Volume: 58 Issue: 12 Pages: 2781-2190
  • DOI: 10.1007/s00125-015-3763-9
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• [Journal Article] Effects of HLA-DPB1 genotypes on chronic hepatitis B infection in Japanese individuals. (2015)
  • Author(s): N. Nishida, J. Ohashi, M. Sugiyama, T. Tsuchiura, K. Yamamoto, K. Hino, M. Honda, S. Kaneko, H. Yatsuhashi, K. Koike, O. Yokosuka, E. Tanaka, A. Taketomi, M. Kurosaki, N. Izumi, N. Sakamoto, Y. Eguchi, T. Sasazuki, K. Tokunaga, and M. Mizokami
  • Journal Title: Tissue Antigens Volume: 5 Issue: 6 Pages: 406-412
  • DOI: 10.1111/tan.12684
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• [Journal Article] Mapping the genetic diversity of HLA haplotypes in the Japanese populations. (2015)
  • Author(s): W. Y. Saw, X. Liu, C. C. Khor, F. Takeuchi, T. Katsuya, R. Kimura, T. Nabika, T. Ohkubo, Y. Tabara, K. Yamamoto, M. Yokota, Japanese Genome Variation Consortium, Y. Y. Teo, and N. Kato
  • Journal Title: Scientific Reports Volume: 5 Issue: 1 Pages: 17855-17855
  • DOI: 10.1038/srep17855
  • NAID: 120006892738
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• [Journal Article] Genome wide surveillance of mismatched alleles for graft versus host disease in stem cell transplantation. (2015)
  • Author(s): A. Sato-Otsubo, Y. Nannya, K. Kashiwase, M. Onizuka, F. Azuma, Y. Akatsuka, Y. Ogino, M. Satake, M. Sanada, S. Chiba, H. Saji, H. Inoko, G. C. Kennedy, K. Yamamoto, S. Morishima, Y. Morishima, Y. Kodera, T. Sasazuki, and S. Ogawa
  • Journal Title: blood Volume: 126 Issue: 25 Pages: 2752-2763
  • DOI: 10.1182/blood-2015-03-630707
  • Peer Reviewed
• [Presentation] 緑色硫黄細菌Chlorobaculum limnaeumを用いたバクテリオクロロフィル c、d、eおよびfの生体内でのエネルギー移動効率の比較. (2018)
  • Author(s): 原田二朗, 柴田 穣, 寺村美里, 溝口 正, 木下雄介, 山本 健, 民秋 均
  • Organizer: 日本化学会年会 第98春季年会(2018)
• [Presentation] 繊維性非酸素発生型光合成細菌Chloroflexus aurantiacusの培養条件で変化するカロテノイド合成系. (2018)
  • Author(s): 原田二朗, 山本 健, 高市真一
  • Organizer: 第59回日本植物生理学会年会
• [Presentation] バクテリオクロロフィル eを合成する緑色硫黄細菌で見られる赤色光に対する応答. (2018)
  • Author(s): 原田二朗, 溝口 正, 木下雄介, 山本 健, 民秋 均
  • Organizer: 第59回日本植物生理学会年会
• [Presentation] 光化学系I型反応中心の紅色光合成細菌への導入. (2018)
  • Author(s): 塚谷祐介, 浅井智広, 原田二朗, 溝口 正, 民秋 均, 増田真二
  • Organizer: 第59回日本植物生理学会年会
• [Presentation] 植物型カロテノイド合成系におけるZ-ISO異性化酵素の普遍性. (2018)
  • Author(s): 中澤慶翼, 山田昌治, 加藤翔太, 篠村知子, 原田二朗, 高市真一, 杉山健二郎
  • Organizer: 第59回日本植物生理学会年会
• [Presentation] バクテリオクロロフィル eを合成する緑色硫黄細菌の赤色光照射下において蓄積するC8位ビニル色素の役割についての考察 (2017)
  • Author(s): 原田二朗、溝口 正、木下雄介、岡田知沙、山本 健、民秋 均
  • Organizer: 第58回日本植物生理学会年会
  • Place of Presentation: 鹿児島大学 郡元キャンパス(鹿児島)
  • Year and Date: 2017-03-16
• [Presentation] Bacteriochlorophyll biosynthetic pathways based on substrate specificities of enzymes for chlorosomal pigment biosynthesis (2017)
  • Author(s): Teramura M, Harada J, Mizoguchi T, Tamiaki H
  • Organizer: 第58回日本植物生理学会年会
  • Place of Presentation: 鹿児島大学 郡元キャンパス(鹿児島)
  • Year and Date: 2017-03-16
• [Presentation] 緑色糸状細菌Chloroflexus autantiacusのフィトエン不飽和化酵素はCrtI型である (2017)
  • Author(s): 高市真一、原田二朗
  • Organizer: 第58回日本植物生理学会年会
  • Place of Presentation: 鹿児島大学 郡元キャンパス(鹿児島)
  • Year and Date: 2017-03-16
• [Presentation] The photosynthetic competences of chlorosomes containing bacteriochlorophyll c, d, e, or f in the green sulfur bacterium Chlorobaculum limnaeum mutants cells (2017)
  • Author(s): Harada J, Shibata Y, Mizoguchi T, Ryono M, Teramura M, Yamamoto K, Tamiaki H
  • Organizer: 2017 International Conference on Artificial Photosynthesis
  • Place of Presentation: 立命館大学 朱雀キャンパス (日本・京都)
  • Year and Date: 2017-03-02
  • Int'l Joint Research
• [Presentation] Isolation and characterization of bacteriochlorophyll-e pigment possessing a vinyl group at C8 position (2017)
  • Author(s): Kinoshita Y, Mizoguchi T, Ogasawara S, Harada J, Okada C, Tamiaki H
  • Organizer: 2017 International Conference on Artificial Photosynthesis
  • Place of Presentation: 立命館大学 朱雀キャンパス (日本・京都)
  • Year and Date: 2017-03-02
  • Int'l Joint Research
• [Presentation] 緑色硫黄細菌Chlorobaculum limnaeumが赤色光照射下において合成するC8位ビニルバクテリオクロロフィル eの役割について. (2017)
  • Author(s): 原田二朗, 溝口 正, 木下雄介, 小笠原 伸, 山本 健, 民秋 均
  • Organizer: 第8回光合成学会年会およびシンポジウム
• [Presentation] Two synthetic pathways from phytoene to lycopene in phototrophs: Chloroflexus aurantiacus has CrtI-type phytoene desaturase. (2017)
  • Author(s): Takaichi S, Harada J
  • Organizer: 18th International Symposium on Carotenoids
  • Int'l Joint Research
• [Presentation] 光合成細菌のアンテナクロロフィル色素の代謝系. (2017)
  • Author(s): 原田二朗
  • Organizer: 第25回「光合成セミナー2017：反応中心と色素系の多様性」
• [Presentation] 多才な色素合成酵素CORとBchJに関する生化学分子生物学的研究. (2017)
  • Author(s): 塚谷祐介, 原田二朗, 溝口 正, 藤田祐一, 民秋 均
  • Organizer: 第25回「光合成セミナー2017：反応中心と色素系の多様性」
• [Presentation] 天然クロロフィルのゲル化の検討. (2017)
  • Author(s): 原田二朗, 溝口 正, 木下雄介, 山本 健, 民秋 均
  • Organizer: 第11回バイオ関連化学シンポジウム
• [Presentation] 繊維状非酸素発生型光合成細菌Chloroflexus aurantiacusのカロテノイド合成経路：ゲノムに見られる3つのCrtIホモログとCrtYの大腸菌内での機能解析. (2017)
  • Author(s): 原田二朗, 山本 健, 高市真一
  • Organizer: 第31回カロテノイド研究談話会
• [Presentation] In vitro assay of stereoselective enzymatic reactions in bacteriochlorophyll biosynthetic pathways. (2017)
  • Author(s): M. Teramura, J. Harada, Y. Tsukatani, T. Mizoguchi, H. Tamiaki
  • Organizer: 8th International Conferene “Photosunthesis and Hydrogen Energy Research for Sustainability -2017”
  • Int'l Joint Research
• [Presentation] Hydridization of amphiphilic zinc chlorophyll derivatives with light-harvesting complexes chlorosomes in green sulfur photosynthetic bacteria. (2017)
  • Author(s): H. Yamashita, N. Takahashi, J. Harada, H. Tamiaki, Y. Saga
  • Organizer: The Second International Symposium on Biofunctional Chemistry
  • Int'l Joint Research
• [Presentation] 色素合成酵素の活性解析に基づく緑色硫黄細菌のバクテリオクロロフィル生合成経路の考察 (2017)
  • Author(s): 寺村美里、原田二朗、溝口 正、民秋 均
  • Organizer: 第2回光合成細菌ワークショップ
  • Place of Presentation: 鹿児島大学 郡元キャンパス(鹿児島)
• [Presentation] 緑色硫黄細菌Chlorobaculum tepidumの色素合成酵素の生化学的解析に基づくクロロフィル生合成経路の考察 (2016)
  • Author(s): 寺村美里、原田二朗、溝口 正、民秋 均
  • Organizer: 新学術領域「人工光合成」若手育成シンポジウム-生物から学び、応用する光反応-
  • Place of Presentation: 立命館大学・びわこくさつキャンパス (滋賀)
  • Year and Date: 2016-11-18
• [Presentation] I86D変異フィコシアノヒリン:フェレトキシン還元酵素(PcyA)の精密構造解析から見えてきた活性部位周辺酸性残基の水素化状態 (2016)
  • Author(s): 萩原義徳, 和田 啓, 入川鉄平, 佐藤秀明, 海野昌喜, 山本 健, 福山恵一, 杉島正一
  • Organizer: 第89回日本生化学会大会
  • Place of Presentation: 仙台国際センター (宮城)
  • Year and Date: 2016-09-25
• [Presentation] 緑色イオウ光合成細菌の光捕集アンテナ色素合成系に必須なC3位ビニルヒドラターゼおよびC132位デメトキシカルボニラーゼの生体内での役割 (2016)
  • Author(s): 原田二朗、寺村美里、溝口 正、塚谷祐介、山本 健、民秋 均
  • Organizer: 第10回バイオ関連化学シンポジウム
  • Place of Presentation: 石川県立音楽堂、もてなしドーム地下イベント広場 (石川)
  • Year and Date: 2016-09-07
• [Presentation] Chlorophyllide a oxidoreductase identified as the third divinyl reductase, specifically works in bacteriochlorophyll a biosynthesis (2016)
  • Author(s): Harada J, Mizoguchi T, Tsukatani Y, Yokono M, Tanaka A, Yamamoto K, Tamiaki H
  • Organizer: The 17th International Congress on Photosynthesis Research
  • Place of Presentation: Maastricht Exhibition & Congress Centre (オランダ・マーストリヒト)
  • Year and Date: 2016-08-07
  • Int'l Joint Research
• [Presentation] Biochemical characterization of C132-demethoxycarbonylase involved in the biosynthetic pathways of chlorosomal pigments (2016)
  • Author(s): Teramura M, Harada J, Mizoguchi T, Tamiaki H
  • Organizer: The 17th International Congress on Photosynthesis Research
  • Place of Presentation: Maastricht Exhibition & Congress Centre (オランダ・マーストリヒト)
  • Year and Date: 2016-08-07
  • Int'l Joint Research
• [Presentation] Molecular structures and functions of chlorophylls-a having a geranylgeranyl, dihydrogeranylgeranyl or tetrahydrogeranylgeranyl ester as the 17-propionate residue in a diatom Chaetoceras calcitrans (2016)
  • Author(s): Mizoguchi T, Isaji M, Harada J, Yamano N, Fujii R, Tamiaki H
  • Organizer: The 17th International Congress on Photosynthesis Research
  • Place of Presentation: Maastricht Exhibition & Congress Centre (オランダ・マーストリヒト)
  • Year and Date: 2016-08-07
  • Int'l Joint Research
• [Presentation] Adaptation of green sulfur bacteria to limited-light conditions by transcriptional regulation of two C3-vinyl hydratase genes, bchF and bchV (2016)
  • Author(s): Harada J, Teramura M, Mizoguchi T, Tsukatani Y, Yamamoto K, Tamiaki H
  • Organizer: Light Harvesting Satellite Meeting of the 17th International Congress on Photosynthesis Research
  • Place of Presentation: Hotel Zuiderduin (オランダ・エグモント アー ゼー)
  • Year and Date: 2016-08-04
  • Int'l Joint Research
• [Presentation] Biosynthetic pathways of bacteriochlorophylls working in light-harvesting chlorosomes (2016)
  • Author(s): Teramura M, Harada J, Mizoguchi T, Tamiaki H
  • Organizer: Light Harvesting Satellite Meeting of the 17th International Congress on Photosynthesis Research
  • Place of Presentation: Hotel Zuiderduin (オランダ・エグモント アー ゼー)
  • Year and Date: 2016-08-04
  • Int'l Joint Research
• [Presentation] 酸素発生型光合成への進化過程の遺伝子工学的研究 (2016)
  • Author(s): 塚谷祐介、野路智康、原田二朗、溝口 正、民秋 均、増田真二
  • Organizer: 第19回日本光生物学協会年会
  • Place of Presentation: 東京大学・本郷キャンパス (東京)
  • Year and Date: 2016-07-28
• [Presentation] 緑色硫黄光合成細菌内でのクロロソーム色素合成経路への分岐に関わるC132位デメトキシカルボニル化酵素BciCの解析 (2016)
  • Author(s): 原田二朗、寺村美里、溝口 正、山本 健、民秋 均
  • Organizer: 第24回「光合成セミナー2016：反応中心と色素系の多様性」
  • Place of Presentation: 龍谷大学・深草キャンパス (京都)
  • Year and Date: 2016-07-09
• [Presentation] 緑色硫黄細菌における2つのクロロフィル水和酵素の機能と光に応じたアンテナ系の調節との関係 (2016)
  • Author(s): 寺村美里、原田二朗、溝口 正、民秋 均
  • Organizer: 第24回「光合成セミナー2016：反応中心と色素系の多様性」
  • Place of Presentation: 龍谷大学・深草キャンパス (京都)
  • Year and Date: 2016-07-09
• [Presentation] Stereospecific hydratases for bacteriochlorophyll synthesis regulate light-harvesting ability of chlorophyllous self-aggregates in Chlorobaculum tepidum (2016)
  • Author(s): Teramura M, Harada J, Mizoguchi T, Tamiaki H
  • Organizer: Twelfth International Workshop on Supramolecular Nanoscience of Chemically Programmed Pigments (SNCPP16)
  • Place of Presentation: 立命館大学・びわこくさつキャンパス (滋賀)
  • Year and Date: 2016-06-17
  • Int'l Joint Research
• [Presentation] I86D変異フィコシアノヒリン:フェレトキシン還元酵素(PcyA)の精密構造解析から見えてきた活性部位周辺酸性残基の水素化状態 (2016)
  • Author(s): 佐藤秀明，杉島正一，塚口 舞，増子隆博，小俣義明，和田 啓，久枝良雄，山本 健，野口正人
  • Organizer: 第16回日本蛋白質科学会年会
  • Place of Presentation: 福岡国際会議場 (福岡)
  • Year and Date: 2016-06-07
• [Presentation] NADPH-シトクロムP450還元酵素からヘムオキシゲナーゼへの電子移動反応の生化学的検討 (2016)
  • Author(s): 杉島正一，平 順一，佐藤秀明，野口正人，山本 健，坂本 寛
  • Organizer: 第16回日本蛋白質科学会年会
  • Place of Presentation: 福岡国際会議場 (福岡)
  • Year and Date: 2016-06-07
• [Presentation] バクテリオクロロフィルの生合成から見た光合成の進化 (2016)
  • Author(s): 原田二朗、民秋 均、山本 健
  • Organizer: 第7回日本光合成学会年会およびシンポジウム
  • Place of Presentation: 東京理科大学・葛飾キャンパス (東京)
  • Year and Date: 2016-05-27
• [Presentation] 緑色硫黄細菌のアンテナ系色素合成酵素の活性解析から考察するクロロフィル生合成経路 (2016)
  • Author(s): 寺村美里、原田二朗、溝口 正
  • Organizer: 第7回日本光合成学会年会およびシンポジウム
  • Place of Presentation: 東京理科大学・葛飾キャンパス (東京)
  • Year and Date: 2016-05-27
• [Presentation] 緑色イオウ光合成細菌の自己会合体色素に必要なC3^1位ビニル基の水和反応およびC132位メトキシカルボニル基の脱落に関わる酵素の解析. (2016)
  • Author(s): 原田二朗、寺村美里、溝口 正、塚谷祐介、山本 健、民秋 均
  • Organizer: 日本化学会第96春季年会
  • Place of Presentation: 同志社大学京田辺キャンパス(京都府・京田辺市)
  • Year and Date: 2016-03-24
• [Presentation] 緑色硫黄光合成細菌のバクテリオクロロフィル合成系で働く2種類の水和酵素のin vitro反応. (2016)
  • Author(s): 寺村美里、原田二朗、民秋 均
  • Organizer: 日本化学会第96春季年会
  • Place of Presentation: 同志社大学京田辺キャンパス(京都府・京田辺市)
  • Year and Date: 2016-03-24
• [Presentation] Functional analysis of chlorophyllide a demethoxycarbonylase, BciC, working in chlorosomal pigment biosynthetic pathways of green sulfur bacteria. (2016)
  • Author(s): J. Harada, M. Teramura, T. Mizoguchi, K. Yamamoto, and H. Tamiaki
  • Organizer: 第57回日本植物生理学会年会
  • Place of Presentation: 岩手大学上田キャンパス(岩手県・盛岡市)
  • Year and Date: 2016-03-18
• [Presentation] Molecular structures and functional characterization of chlorophyll-a carrying dehydrogenated forms of phytyl group in the 17-proionate residue of a diatom Chaetoceros calcitrans. (2016)
  • Author(s): T. Mizoguchi, M. Isaji, J. Harada, N. Yamano, R. Fujii, and H. Tamiaki
  • Organizer: 第57回日本植物生理学会年会
  • Place of Presentation: 岩手大学上田キャンパス(岩手県・盛岡市)
  • Year and Date: 2016-03-18
• [Presentation] Glycolipid compositions in green sulfur bacterial mutants lacking chlorosome envelope proteins (2016)
  • Author(s): Y. Tsukatani, T. Mizoguchi, and H. Tamiaki
  • Organizer: 第57回日本植物生理学会年会
  • Place of Presentation: 岩手大学上田キャンパス(岩手県・盛岡市)
  • Year and Date: 2016-03-18
• [Presentation] ゲノム比較から紐解くバクテリオクロロフィル生合成系の新機軸. (2016)
  • Author(s): 塚谷祐介、原田二朗、野亦次郎、山本治樹、藤田祐一、溝口 正、民秋 均
  • Organizer: 第10回日本ゲノム微生物学会年会
  • Place of Presentation: 東京工業大学大岡山キャンパス(東京都・目黒区)
  • Year and Date: 2016-03-04
• [Presentation] Constructions and characterizations of mutants containing bacteriochlorophyll c, d, e, or f of the green sulfur bacterium Chlorobaculum limnaeum. (2015)
  • Author(s): J. Harada, Y. Shibata, M. Ryono, M. Teramura, K. Yamamoto, T. Mizoguchi, and H. Tamiaki
  • Organizer: The International Chemical Congress of Pacific Basin Societies (Pacifichem 2015)
  • Place of Presentation: ホノルル(アメリカ)
  • Year and Date: 2015-12-14
  • Int'l Joint Research
• [Presentation] In-vitro assay to clarify the substrate specificity of demethoxycarbonylase involved in chlorosomal bacteriochlorophyll biosynthesis. (2015)
  • Author(s): M. Teramura, J. Harada, T. Mizoguchi, and H. Tamiaki
  • Organizer: The International Chemical Congress of Pacific Basin Societies (Pacifichem 2015)
  • Place of Presentation: ホノルル(アメリカ)
  • Year and Date: 2015-12-14
  • Int'l Joint Research
• [Presentation] Construction of artificial light-harvesting devices using the isolated chlorosomes from photosynthetic green bacteria. (2015)
  • Author(s): M. Ryono, J. Harada, Y. Tsukatani, T. Mizoguchi, and H. Tamiaki
  • Organizer: Construction of artificial light-harvesting devices using the isolated chlorosomes from photosynthetic green bacteria.
  • Place of Presentation: ホノルル(アメリカ)
  • Year and Date: 2015-12-14
  • Int'l Joint Research
• [Presentation] Observation of 8-vinyl-12-ethyl- bacteriochlorophyll-e in a green sulfur bacterium cultured by intense red-light illumination. (2015)
  • Author(s): C. Okada, T. Mizoguchi, J. Harada, and H. Tamiaki
  • Organizer: Construction of artificial light-harvesting devices using the isolated chlorosomes from photosynthetic green bacteria.
  • Place of Presentation: ホノルル(アメリカ)
  • Year and Date: 2015-12-14
  • Int'l Joint Research
• [Presentation] Synthesis of bacteriochlorophyll-d amino-analogs and their self-aggregation. (2015)
  • Author(s): H. Watanabe, T. Mizoguchi and H. Tamiaki
  • Organizer: Construction of artificial light-harvesting devices using the isolated chlorosomes from photosynthetic green bacteria.
  • Place of Presentation: ホノルル(アメリカ)
  • Year and Date: 2015-12-14
  • Int'l Joint Research
• [Presentation] シアノバクテリア由来ビリベルジン還元酵素-基質複合体の結晶構造解析. (2015)
  • Author(s): 高尾春奈、平林 佳、渡邊 彩、萩原義徳、原田二朗、榊原陽一、水光正仁、福山恵一、杉島正一、和田 啓
  • Organizer: 第38回日本分子生物学会年会・第88回日本生化学大会 合同大会
  • Place of Presentation: 神戸ポートピアアイランド(兵庫県・神戸市)
  • Year and Date: 2015-12-01
• [Presentation] ヒドロキシメチルビランシンターゼ-阻害剤複合体の結晶構造解析。 (2015)
  • Author(s): 佐藤秀明、杉島正一、塚口 舞、増子隆博、小俣義明、和田 啓、久枝良雄、山本 健、野口正人
  • Organizer: 第38回日本分子生物学会年会・第88回日本生化学大会 合同大会
  • Place of Presentation: 神戸ポートピアアイランド(兵庫県・神戸市)
  • Year and Date: 2015-12-01
• [Presentation] シアノバクテリア由来ビリベルジン還元酵素の結晶構造解析に基づいた反応機構. (2015)
  • Author(s): 高尾春奈、平林 佳、萩原義徳、原田二朗、,福山恵一、杉島正一、和田 啓
  • Organizer: ユーグレナ研究会 第31回研究集会 (北岡正三郎先生メモリアル集会)
  • Place of Presentation: Kitenビル コンベンションホール(宮崎県・宮崎市)
  • Year and Date: 2015-11-07
• [Presentation] 大きな構造変化を伴うシトクロムP450還元酵素からヘムオキシゲナーゼへの電子伝達機構 (2015)
  • Author(s): 杉島正一、平 順一、佐藤秀明、野口正人、山本 健、坂本 寛
  • Organizer: 日本結晶学会平成27年度年会
  • Place of Presentation: 大阪府立大学中百舌鳥キャンパス(大阪府・堺市)
  • Year and Date: 2015-10-17
• [Presentation] 緑色硫黄光合成細菌の巨大アンテナ系内におけるクロロフィル超分子構造の形成を光強度に応じてコントロールする2つの水和化酵素の機能解析. (2015)
  • Author(s): 原田二朗、寺村美里、溝口 正、塚谷祐介、山本 健、民秋 均
  • Organizer: 第9回バイオ関連化学シンポジウム
  • Place of Presentation: 熊本大学黒髪キャンパス(熊本県・熊本市)
  • Year and Date: 2015-09-10
• [Presentation] 緑色硫黄光合成細菌の光捕集アンテナ超分子複合体・クロロゾームを構成する機能分子の細胞内改変. (2015)
  • Author(s): 佐賀佳央、林 圭介、廣田圭耶、吉田望見、山田翔大、原田二朗、溝口 正、民秋 均
  • Organizer: 第9回バイオ関連化学シンポジウム
  • Place of Presentation: 熊本大学黒髪キャンパス(熊本県・熊本市)
  • Year and Date: 2015-09-10
• [Presentation] ヒト由来ペプチドアミド化酵素PAMに対する癌代謝物の阻害効果. (2015)
  • Author(s): 下川千寿、城田（原田）沙織、佐藤秀明、杉島正一、原田二朗、東元 祐一郎、Mario L. Amzel、野口正人
  • Organizer: 第9回バイオ関連化学シンポジウム
  • Place of Presentation: 熊本大学黒髪キャンパス(熊本県・熊本市)
  • Year and Date: 2015-09-10
• [Presentation] 基質類似体を結合したヒドロキシメチルビラン合成酵素の結晶構造解析. (2015)
  • Author(s): 佐藤秀明、杉島正一、塚口 舞、増子隆博、小俣義明、和田 啓、久枝良雄、山本 健、野口正人
  • Organizer: 第9回バイオ関連化学シンポジウム
  • Place of Presentation: 熊本大学黒髪キャンパス(熊本県・熊本市)
  • Year and Date: 2015-09-10
• [Presentation] 変異NADPH-シトクロムP450還元酵素(CPR)を用いたCPRからヘムオキシゲナーゼへの電子伝達機構の検討. (2015)
  • Author(s): 杉島正一、平 順一、佐藤秀明、野口正人、山本 健、坂本 寛
  • Organizer: 第39回蛋白質と酵素の構造と機能に関する九州シンポジウム
  • Place of Presentation: 公立学校共済組合別府保養所 別府宝泉荘(大分県・別府市)
  • Year and Date: 2015-09-10
• [Presentation] Functional versatility and application of a nitrogenase-like enzyme, chlorophyllide a oxidoreductase, on bacteriochlorophyll biosynthesis. (2015)
  • Author(s): Y. Tsukatani, J. Harada, J. Nomata, H. Yamamoto, T. Mizoguchi, Y. Fujita, and H. Tamiaki
  • Organizer: 15th International Symposium on Phototrophic Prokaryotes
  • Place of Presentation: チュービンゲン(ドイツ)
  • Year and Date: 2015-08-02
  • Int'l Joint Research
• [Presentation] Construction of artificial heterodimeric photosynthetic reaction center in the green sulfur bacterium Chlorobaculum tepidum. (2015)
  • Author(s): C. Azai, K. Kim, J. Harada, and H. Oh-oka
  • Organizer: 15th International Symposium on Phototrophic Prokaryotes
  • Place of Presentation: チュービンゲン(ドイツ)
  • Year and Date: 2015-08-02
  • Int'l Joint Research
• [Presentation] Bacteriochlorophyll a synthesis in the green sulfur bacterium Chlorobaculum tepidum mutant lacking BchX, a subunit of chlorophyllide a oxidoreductase. (2015)
  • Author(s): Chihiro Azai, Tadashi Mizoguchi, Hitoshi Tamiaki and Hirozo Oh-oka
  • Organizer: 15th International Symposium on Phototrophic Prokaryotes
  • Place of Presentation: チュービンゲン(ドイツ)
  • Year and Date: 2015-08-02
  • Int'l Joint Research
• [Presentation] 植物細胞壁多糖ラムノガラクツロナンI由来のオリゴ糖調製とラムノガラクツロナンI生合成酵素活性測定法構築. (2015)
  • Author(s): 村峻佑, 上原洋平, 松本直樹, 牧 祐介, 溝口 正, 民秋 均, 石水 毅
  • Organizer: 第34回日本糖質学会年会
  • Place of Presentation: 東京大学本郷キャンパス(東京都・文京区)
  • Year and Date: 2015-07-31
• [Presentation] 光強度に応じて巨大アンテナ系内のクロロフィル色素の超分子構造をコントロールする2つの水和化酵素BchFとBchVの機能解析. (2015)
  • Author(s): 原田二朗、寺村美里、溝口 正、塚谷祐介、山本 健、民秋 均
  • Organizer: 第23回「光合成セミナー2015：反応中心と色素系の多様性」
  • Place of Presentation: 龍谷大学大宮キャンパス(京都府・京都市)
  • Year and Date: 2015-07-11
• [Presentation] 緑色硫黄細菌の光捕集アンテナ色素合成系で働くBciC酵素のin vitroでの反応. (2015)
  • Author(s): 寺村美里、原田二朗、溝口 正、民秋 均
  • Organizer: 第23回「光合成セミナー2015：反応中心と色素系の多様性」
  • Place of Presentation: 龍谷大学大宮キャンパス(京都府・京都市)
  • Year and Date: 2015-07-11
• [Presentation] クロロゾームモデル：3^1位アミノ基型クロロフィル色素の自己会合挙動. (2015)
  • Author(s): 渡邉弘晃、溝口 正、民秋 均
  • Organizer: 第23回「光合成セミナー2015：反応中心と色素系の多様性」
  • Place of Presentation: 龍谷大学大宮キャンパス(京都府・京都市)
  • Year and Date: 2015-07-11
• [Presentation] NADP+結合型シアノバクテリア由来ビリベルジン還元酵素の結晶構造. (2015)
  • Author(s): 高尾春奈、平林 佳、渡邊 彩、萩原義徳、原田二朗、榊原陽一、水光正仁、福山恵一、杉島正一、和田 啓
  • Organizer: 第15回日本蛋白質科学会年会
  • Place of Presentation: あわぎんホール(徳島県・徳島市)
  • Year and Date: 2015-06-24
• [Presentation] Mechanism for the electron transfer from P450 reductase to heme oxygenase. (2015)
  • Author(s): M. Sugishima, H. Sato, J. Taira, H. Sakamoto, Y. Higashimoto, J Harada, J. Yamamoto, and M. Noguchi
  • Organizer: RIKEN Symposium series: “Metals in Biology” in Wako
  • Place of Presentation: 理化学研究所和光地区(埼玉県・和光市)
  • Year and Date: 2015-06-16
  • Int'l Joint Research
• [Presentation] Inhibition of human peptidylglycine α-amidating monooxygenase. (2015)
  • Author(s): C. Shimokawa, S. Shirota-Harada, H. Sato, M. Sugishima, J. Harada, Y. Higashimoto, M. L. Amzel, and M. Noguchi
  • Organizer: RIKEN Symposium series: “Metals in Biology” in Wako
  • Place of Presentation: 理化学研究所和光地区(埼玉県・和光市)
  • Year and Date: 2015-06-16
  • Int'l Joint Research
• [Presentation] An Inhibitory Effect of a Porphobilinogen Derivative on Hydroxymethylbilane Synthase and the Crystal Structure of the Enzyme-Inhibitor Complex (RIKEN Symposium series (2015)
  • Author(s): H. Sato, M. Sugishima, M. Tsukaguchi, T. Masuko, Y. Omata, K. Wada, Y. Hisaeda, K. Yamamoto, and M. Noguchi
  • Organizer: RIKEN Symposium series: “Metals in Biology” in Wako
  • Place of Presentation: 理化学研究所和光地区(埼玉県・和光市)
  • Year and Date: 2015-06-16
  • Int'l Joint Research
• [Presentation] Inhibitory Effect of a Novel Porphobilinogen Analog on the Synthesis of a Heme Precursor by Hydroxymethylbilane Synthase. (2015)
  • Author(s): H. Sato, M. Sugishima, M. Tsukaguchi, T. Masuko, Y. Omata, K. Wada, Y. Hisaeda, M. Noguchi, and K. Yamamoto
  • Organizer: 19th International Conference on Cytochrome P450 (ICCP450 Tokyo 2015
  • Place of Presentation: 国立オリンピック記念青少年総合センター(東京都・渋谷区)
  • Year and Date: 2015-06-12
  • Int'l Joint Research
• [Presentation] In vitro assays of demethoxycarbonylation of self-aggregative bacteriochlorophylls in light-harvesting antennas. (2015)
  • Author(s): M. Teramura, J. Harada, T. Mizoguchi, and H. Tamiaki
  • Organizer: Eleventh International Workshop in Supramolecular Nanoscience of Chemically Programmed Pigments
  • Place of Presentation: 立命館大学びわこ・くさつキャンパス(滋賀県・草津市)
  • Year and Date: 2015-05-29
  • Int'l Joint Research
• [Presentation] “Isolation of chlorosomes from various photosynthetic green bacteria. (2015)
  • Author(s): M. Ryono, J. Harada, Y. Tsukatani, T. Mizoguchi, and H. Tamiaki
  • Organizer: Eleventh International Workshop in Supramolecular Nanoscience of Chemically Programmed Pigments
  • Place of Presentation: 立命館大学びわこ・くさつキャンパス(滋賀県・草津市)
  • Year and Date: 2015-05-29
  • Int'l Joint Research
• [Presentation] Self-aggregation of synthetic bacteriochlorophyll-d amino-analogs in an aqueous alkaline micelle solution. (2015)
  • Author(s): H. Watanabe, T. Mizoguchi and H. Tamiaki
  • Organizer: Eleventh International Workshop in Supramolecular Nanoscience of Chemically Programmed Pigments
  • Place of Presentation: 立命館大学びわこ・くさつキャンパス(滋賀県・草津市)
  • Year and Date: 2015-05-29
  • Int'l Joint Research
• [Presentation] Characterization of C8-vinyl reduction activity of BciA from Rhodobacter capsulatus. (2015)
  • Author(s): M. Kobayashi, C. Azai, T. Mizoguchi, H. Tamiaki, Y. Tsukatani and K. Terauchi
  • Organizer: Eleventh International Workshop on Supramolecular Nanoscience of Chemically Programmed Pigments
  • Place of Presentation: 立命館大学びわこ・くさつキャンパス(滋賀県・草津市)
  • Year and Date: 2015-05-29
  • Int'l Joint Research
• [Presentation] ホモダイマー光合成反応中心複合体の人工的ヘテロダイマー化. (2015)
  • Author(s): 浅井智広、Kwang Kim、近藤 徹、原田二朗、伊藤 繁、大岡宏造
  • Organizer: 第62回日本生化学会近畿支部例会
  • Place of Presentation: 立命館大学びわこ・くさつキャンパス(滋賀県・草津市)
  • Year and Date: 2015-05-22
• [Presentation] 植物細胞壁ペクチン由来ラムノガラクツロナンI(RG-I)オリゴ糖の調製とRG-I生合成酵素の活性測定法の構築. (2015)
  • Author(s): 田村峻佑、上原洋平、松本直樹、溝口 正、民秋 均、石水 毅
  • Organizer: 第62回日本生化学会近畿支部例会
  • Place of Presentation: 立命館大学びわこ・くさつキャンパス(滋賀県・草津市)
  • Year and Date: 2015-05-22
• [Presentation] 緑色硫黄細菌のアンテナ色素の異性体組成変化に関わる２つの水和化酵素の役割. (2015)
  • Author(s): 原田二朗、寺村美里、溝口 正、塚谷祐介、山本 健、民秋 均
  • Organizer: 第6回日本光合成学会年会および公開シンポジウム
  • Place of Presentation: 岡山国際交流センター(岡山県・岡山市)
  • Year and Date: 2015-05-22
• [Presentation] 緑色硫黄光合成細菌Chlorobaculum tepidumのバクテリオクロロフィル aシンターゼーゼにおけるイソプレノイド基質依存性. (2015)
  • Author(s): 佐賀佳央、廣田圭耶、原田二朗、民秋 均
  • Organizer: 第6回日本光合成学会年会および公開シンポジウム
  • Place of Presentation: 岡山国際交流センター(岡山県・岡山市)
  • Year and Date: 2015-05-22
• [Presentation] ヒドロキシメチルビランシンターゼに対する2-ヨードポルホビリノーゲンの阻害効果と複合体の立体構造の解析. (2015)
  • Author(s): 佐藤秀明，塚口 舞，杉島正一，増子隆博，小俣義明，和田 啓，久枝良雄，山本 健，野口正人
  • Organizer: 平成27年度日本生化学会九州支部例会
  • Place of Presentation: 九州大学箱崎キャンパス(福岡県・福岡市)
  • Year and Date: 2015-05-16
• [Remarks] Google Scholar: Jiro Harada
  • URL: https://scholar.google.com/citations?user=M61fT_QAAAAJ&hl=en
• [Remarks] 久留米大学研究者紹介 医学部医化学講座 原田二朗
  • URL: http://research.kurume-u.ac.jp/data.php?scode=82055632889065
• [Remarks] 久留米大学研究者紹介 医化学講座 原田二朗
  • URL: http://research.kurume-u.ac.jp/data.php?scode=82055632889065
• [Remarks] 久留米大学研究者紹介 医学部医化学講座 原田二朗
  • URL: http://research.kurume-u.ac.jp/data.php?scode=82055632889065