Development of intensity-modulated radiation therapy treatment planning based on dose-volume constraints

• Project/Area Number: 15K06110
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Measurement engineering
• Research Institution: The University of Tokushima
• Principal Investigator: YOSHINAGA Tetsuya 徳島大学, 大学院医歯薬学研究部(医学系), 教授 (40220694)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 強度変調放射線治療計画 / 最適化問題 / 微分方程式 / 非線形問題 / 強度変調放射線治療

Outline of Final Research Achievements

A novel approach of using a nonlinear hybrid dynamical system for solving dose-volume constrained inverse problems in intensity-modulated radiation therapy (IMRT) treatment planning was proposed. The concept of acceptable meaning that there exists a nonempty set of radiation beam weights satisfying the given dose-volume constraints was introduced and the issue that the objective and evaluation are different in the conventional planning approach was resolved. We applied the initial value problem of the proposed dynamical system to an acceptable and inconsistent inverse problem and proved that the convergence to an equilibrium in the acceptable set is theoretically guaranteed by using the Lyapunov theorem. We confirmed that one can obtain acceptable beamlets through numerical experiments using phantom data simulating a clinical setup for an acceptable and inconsistent IMRT planning system.

Research Products

• [Journal Article] Remarkable similarities of two pairs of stable and saddle canards in a van der Pol oscillator under extremely weak periodic perturbation (2018)
  • Author(s): Nagata Yuta、Inaba Naohiko、Sekikawa Munehisa、Endo Tetsuro、Fujimoto Ken’ichi、Yoshinaga Tetsuya
  • Journal Title: Progress of Theoretical and Experimental Physics Volume: 2018 Issue: 1 Pages: 1-15
  • DOI: 10.1093/ptep/ptx172
  • NAID: 120006980530
  • Peer Reviewed / Open Access
• [Journal Article] Continuous Analog of Accelerated OS-EM Algorithm for Computed Tomography (2017)
  • Author(s): Tateishi Kiyoko、Yamaguchi Yusaku、Abou Al-Ola Omar M.、Yoshinaga Tetsuya
  • Journal Title: Mathematical Problems in Engineering Volume: 2017 Issue: 1 Pages: 1-8
  • DOI: 10.1155/2017/1564123
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Multivalued Discrete Tomography Using Dynamical System That Describes Competition (2017)
  • Author(s): Kojima Takeshi、Ueta Tetsushi、Yoshinaga Tetsuya
  • Journal Title: Mathematical Problems in Engineering Volume: 2017 Issue: 1 Pages: 1-9
  • DOI: 10.1155/2017/8160354
  • NAID: 120006814110
  • Peer Reviewed / Open Access
• [Journal Article] Discrete-Time Dynamic Image Segmentation Using Oscillators with Adaptive Coupling (2016)
  • Author(s): Mio Kobayashi and Tetsuya Yoshinaga
  • Journal Title: International Journal of Modern Nonlinear Theory and Application Volume: 5:2 Issue: 02 Pages: 93-103
  • DOI: 10.4236/ijmnta.2016.52010
  • Peer Reviewed / Open Access
• [Journal Article] Continuous analog of multiplicative algebraic reconstruction technique for computed tomography (2016)
  • Author(s): Kiyoko Tateishi, Yusaku Yamaguchi, Omar M. Abou Al-Ola, Takeshi Kojima and Tetsuya Yoshinaga
  • Journal Title: Proc. SPIE 9783, Medical Imaging 2016: Physics of Medical Imaging Volume: 9783 Pages: 97834Q-97834Q
  • DOI: 10.1117/12.2214598
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Noise reduction in computed tomography using a multiplicative continuous-time image reconstruction method (2016)
  • Author(s): Yusaku Yamaguchi, Takeshi Kojima and Tetsuya Yoshinaga
  • Journal Title: Proc. SPIE 9783, Medical Imaging 2016: Physics of Medical Imaging Volume: 9783 Pages: 97834T-97834T
  • DOI: 10.1117/12.2216439
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Robustification of a Nonlinear Dynamical System with a Stability Index and a Matrix Inequality (2015)
  • Author(s): Oishi Yasuaki, Mio Kobayashi and Tetsuya Yoshinaga
  • Journal Title: SICE Journal of Control, Measurement, and System Integration Volume: 8:3 Issue: 3 Pages: 209-213
  • DOI: 10.9746/jcmsi.8.209
  • Peer Reviewed / Open Access
• [Journal Article] Dose-volume constrained optimization in intensity-modulated radiation therapy treatment planning (2015)
  • Author(s): Yoshihiro Tanaka, Ken'ichi Fujimoto and Tetsuya Yoshinaga
  • Journal Title: Journal of Inequalities and Applications Volume: 1 Issue: 1
  • DOI: 10.1186/s13660-015-0643-2
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] A novel method of dose-volume-constrained and equivalent-uniform-dose-based optimization in intensity-modulated radiation therapy treatment planning (2018)
  • Author(s): Tetsuya Yoshinaga
  • Organizer: European Congress of Radiology 2018
  • Int'l Joint Research
• [Presentation] An attempt to enlarge basin in discrete tomographic dynamics with a competitive term (2018)
  • Author(s): Takeshi Kojima, Tetsushi Ueta and Tetsuya Yoshinaga
  • Organizer: 2018 RISP International Workshop on Nonlinear Circuits, Communications and Signal Processing
  • Int'l Joint Research
• [Presentation] Tomographic Image Reconstruction via Chi-Square Minimization (2018)
  • Author(s): Yusaku Yamaguchi, Takeshi Kojima and Tetsuya Yoshinaga
  • Organizer: 2018 RISP International Workshop on Nonlinear Circuits, Communications and Signal Processing
  • Int'l Joint Research
• [Presentation] A novel image reconstruction method based on minimization of Hellinger distance (2017)
  • Author(s): Tetsuya Yoshinaga
  • Organizer: European Congress of Radiology 2017
  • Place of Presentation: Austria Center Vienna (Wien, Austria)
  • Year and Date: 2017-03-01
  • Int'l Joint Research
• [Presentation] Applying dynamical method of discrete tomography to X-ray CT imaging (2017)
  • Author(s): Keita Nakahama, Takeshi Kojima and Tetsuya Yoshinaga
  • Organizer: International Forum of Medical Imaging in Asia
  • Place of Presentation: Tenbusu Naha (Naha, Okinawa)
  • Year and Date: 2017-01-20
  • Int'l Joint Research
• [Presentation] Evaluation of metal artifact reduction using dynamical image reconstruction in X-ray CT (2017)
  • Author(s): Yusaku Yamaguchi, Omar M. Abou Al-Ola, Shintaro Harano, Takeshi Kojima and Tetsuya Yoshinaga
  • Organizer: International Forum of Medical Imaging in Asia
  • Place of Presentation: Tenbusu Naha (Naha, Okinawa)
  • Year and Date: 2017-01-20
  • Int'l Joint Research
• [Presentation] 非自律系非線形微分方程式に基づく磁気共鳴画像再構成 (2017)
  • Author(s): 山口 雄作, 兒島 雄志, 吉永 哲哉
  • Organizer: 日本放射線技術学会第73回総会学術大会
• [Presentation] ヘリンガー距離の最小化に基づく動的再構成法のX線CT画像への適用 (2017)
  • Author(s): 池田 大輔, 水田 希咲, 山口 雄作, 兒島 雄志, 吉永 哲哉
  • Organizer: 日本放射線技術学会第73回総会学術大会
• [Presentation] 非線形微分方程式を用いた断層画像再構成とアナログ電子回路 (2017)
  • Author(s): 吉永 哲哉
  • Organizer: 平成29年電気学会電子・情報・システム部門大会
  • Invited
• [Presentation] ガウス写像結合系にみられる分岐現象の解析 (2017)
  • Author(s): 小林 美緒, 吉永 哲哉
  • Organizer: 平成29年電気学会電子・情報・システム部門大会
• [Presentation] 一般化 Hellinger 距離の最小化に基づくCT画像再構成, (2017)
  • Author(s): 工藤 萌, 山口 雄作, 兒島 雄志, 吉永 哲哉
  • Organizer: 第40回日本生体医工学会中国四国支部大会
• [Presentation] Hellinger 距離の最小化に基づくCT画像再構成 (2016)
  • Author(s): 水田 希咲, 山口 雄作, 兒島 雄志, 吉永 哲哉
  • Organizer: 第39回日本生体医工学会中国四国支部大会
  • Place of Presentation: 徳島大学 (徳島県徳島市)
  • Year and Date: 2016-10-15
• [Presentation] 微分方程式を用いた離散トモグラフィのX線CT画像への適用 (2016)
  • Author(s): 中濵 寿太, 兒島 雄志, 吉永 哲哉
  • Organizer: 第39回日本生体医工学会中国四国支部大会
  • Place of Presentation: 徳島大学 (徳島県徳島市)
  • Year and Date: 2016-10-15
• [Presentation] 非線形微分方程式を用いた非デカルト・サンプリングのための磁気共鳴画像再構成 (2016)
  • Author(s): 山口 雄作, 兒島 雄志, 吉永 哲哉
  • Organizer: 第44回日本磁気共鳴医学会大会
  • Place of Presentation: 大宮ソニックシティ (埼玉県さいたま市)
  • Year and Date: 2016-09-09
• [Presentation] 逐次CT画像再構成アルゴリズム構築の新しいアプローチ (2016)
  • Author(s): 立石 貴代子, 山口 雄作, 兒島 雄志, 吉永 哲哉
  • Organizer: 医用画像情報学会(MII)平成28年度年次(第175回)大会
  • Place of Presentation: 大阪市立大学 (大阪府大阪市)
  • Year and Date: 2016-06-11
• [Presentation] 非線形微分方程式に基づく磁気共鳴画像再構成 (2016)
  • Author(s): 山口 雄作, 森 美智子, 兒島 雄志, 吉永 哲哉
  • Organizer: 医用画像情報学会(MII)平成28年度年次(第175回)大会
  • Place of Presentation: 大阪市立大学 (大阪府大阪市)
  • Year and Date: 2016-06-11
• [Presentation] 連続時間 CT 画像再構成法を用いた金属アーチファクト削減の効果 (2016)
  • Author(s): 原野 真太郎, 兒島 雄志, 吉永 哲哉
  • Organizer: 第111回日本医学物理学会学術大会
  • Place of Presentation: パシフィコ横浜 (神奈川県横浜市)
  • Year and Date: 2016-04-14
• [Presentation] 微分方程式を用いた離散トモグラフィ画像再構成 (2016)
  • Author(s): 中濵 寿太, 兒島 雄志, 吉永 哲哉
  • Organizer: 第111回日本医学物理学会学術大会
  • Place of Presentation: パシフィコ横浜 (神奈川県横浜市)
  • Year and Date: 2016-04-14
• [Presentation] 微分方程式を用いた離散トモグラフィ画像再構成法の数値実験による検討 (2016)
  • Author(s): 中濵 寿太, 兒島 雄志, 吉永 哲哉
  • Organizer: 島根県診療放射線技師会平成27年度春季学術大会
  • Place of Presentation: 島根県済生会江津総合病院 (島根県江津市)
  • Year and Date: 2016-03-06
• [Presentation] Noise reduction in computed tomography using a multiplicative continuous-time image reconstruction method (2016)
  • Author(s): Yusaku Yamaguchi, Takeshi Kojima and Tetsuya Yoshinaga
  • Organizer: 2016 SPIE Medical Imaging
  • Place of Presentation: San Diego (USA)
  • Year and Date: 2016-02-27
  • Int'l Joint Research
• [Presentation] Continuous analog of multiplicative algebraic reconstruction technique for computed tomography (2016)
  • Author(s): Kiyoko Tateishi, Yusaku Yamaguchi, Omar M. Abou Al-Ola, Takeshi Kojima and Tetsuya Yoshinaga
  • Organizer: 2016 SPIE Medical Imaging
  • Place of Presentation: San Diego (USA)
  • Year and Date: 2016-02-27
  • Int'l Joint Research
• [Presentation] 非線形微分方程式を用いた離散トモグラフィ (2015)
  • Author(s): 中濵 寿太, 兒島 雄志, 吉永 哲哉
  • Organizer: 第38回日本生体医工学会中国四国支部大会
  • Place of Presentation: 広島市立大学 (広島県広島市)
  • Year and Date: 2015-11-28
• [Presentation] 金属アーチファクト削減のための連続時間 CT 画像再構成法 (2015)
  • Author(s): 原野 真太郎, 兒島 雄志, 吉永 哲哉
  • Organizer: 第38回日本生体医工学会中国四国支部大会
  • Place of Presentation: 広島市立大学 (広島県広島市)
  • Year and Date: 2015-09-19
• [Presentation] 線量体積制約の最適化に基づく強度変調放射線治療計画法の有用性 (2015)
  • Author(s): 田中 義浩, 吉永 哲哉
  • Organizer: 第110回日本医学物理学会学術大会
  • Place of Presentation: 北海道大学 (北海道札幌市)
  • Year and Date: 2015-09-19
• [Presentation] 連続時間CT画像再構成法とその乗法的離散化 (2015)
  • Author(s): 立石 貴代子, 山口 雄作, 吉永 哲哉
  • Organizer: 第110回日本医学物理学会学術大会
  • Place of Presentation: 北海道大学 (北海道札幌市)
  • Year and Date: 2015-09-19
• [Presentation] 雑音低減のための乗法的連続時間CT画像再構成法 (2015)
  • Author(s): 山口 雄作, 吉永 哲哉
  • Organizer: 第110回日本医学物理学会学術大会
  • Place of Presentation: 北海道大学 (北海道札幌市)
  • Year and Date: 2015-09-19
• [Remarks] 医用画像機器工学分野
  • URL: http://www.tokushima-u.ac.jp/med/culture/iyo_gazokiki/index.html