| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
In this study, we analyzed the output pattern of rhythmic motor activity in the left and right sides of a single segment preparation taken from the spinal cord of neonatal mice. Rhythm activity with patterns similar to actual walking can be induced in the motor neuron group in such preparation suggesting that a modular network that forms the rhythm is localized in a single segment. We estimated the average variations in excitatory and inhibitory synaptic conductance during a locomotion cycle from a single voltage trace. We found that the peak of excitatory conductance occurred during the active phase of the locomotor cycle, while the peak of inhibitory conductance occurred during the non-active phase. These results suggest that the locomotor-like activity is generated by push-pull modulation via excitatory and inhibitory synaptic inputs.
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