Study of the molecular-anatomical basis common to neuromodulatory synapses
Project/Area Number |
15K06732
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Nerve anatomy/Neuropathology
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Research Institution | Hokkaido University |
Principal Investigator |
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
|
Keywords | アセチルコリン / ノルアドレナリン / ドーパミン / シナプス / 免疫組織化学 / 電子顕微鏡 / 神経修飾因子 / ドパミン / 線条体 / 分界条床核 / ニューロリギン / ニューレキシン / アセチルコリン受容体 |
Outline of Final Research Achievements |
We examined by immunohistochemistry the molecular composition of synaptic structures which release neuromodulators including dopamine, acetylcholine, and noradrenaline in the brain. We revealed that these synapses were composed of non-GABAergic presynaptic structures and GABAergic postsynaptic membranes. This mismatch between presynaptic and postsynaptic structures at distinct neuromodulator synapses suggests GABAergic postsynaptic molecules commonly anchor the molecular machinery to release neuromodulators to target structures.
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Report
(4 results)
Research Products
(16 results)
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[Journal Article] Ventrolateral Striatal Medium Spiny Neurons Positively Regulate Food-Incentive, Goal-Directed Behavior Independently of D1 and D2 Selectivity.2017
Author(s)
Natsubori A, Tsutsui-Kimura I, Nishida H, Bouchekioua Y, Sekiya H, Uchigashima M, Watanabe M, de Kerchove d'Exaerde A, Mimura M, Takata N, Tanaka KF
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Journal Title
J Neurosci
Volume: 37(10)
Pages: 2723-2733
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Dysfunction of ventrolateral striatal dopamine receptor type 2-expressing medium spiny neurons impairs instrumental motivation2017
Author(s)
Tsutsui-Kimura I, Takiue H, Yoshida K, Xu M, Yano R, Ohta H, Nishida H, Bouchekioua Y, Okano H, Uchigashima M, Watanabe M, Takata N, Drew MR, Sano H, Mimura M, Tanaka KF
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Journal Title
Nat Commun
Volume: 8
Pages: 14304
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] The Metabotropic Glutamate Receptor Subtype 1 Mediates Experience-Dependent Maintenance of Mature Synaptic Connectivity in the Visual Thalamus.2016
Author(s)
Narushima M, Uchigashima M, Yagasaki Y, Harada T, Nagumo Y, Uesaka N, Hashimoto K, Aiba A, Watanabe M, Miyata M, Kano M.
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Journal Title
Neuron
Volume: 91(5)
Pages: 1097-109
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Transsynaptic Modulation of Kainate Receptor Functions by C1q-like Proteins.2016
Author(s)
Matsuda K, Budisantoso T, Mitakidis N, Sugaya Y, Miura E, Kakegawa W, Yamasaki M, Konno K, Uchigashima M, Abe M, Watanabe I, Kano M, Watanabe M, Sakimura K, Aricescu AR, Yuzaki M.
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Journal Title
Neuron
Volume: 90(4)
Pages: 752-67
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Phosphoproteomics of the Dopamine Pathway Enables Discovery of Rap1 Activation as a Reward Signal In Vivo2016
Author(s)
Nagai T, Nakamuta S, Kuroda K, Nakauchi S, Nishioka T, Takano T, Zhang X, Tsuboi D, Funahashi Y, Nakano T, Yoshimoto J, Kobayashi K, Uchigashima M, Watanabe M, Miura M, Nishi A, Kobayashi K, Yamada K, Amano M, Kaibuchi K
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Journal Title
Neuron
Volume: 89 (3)
Pages: 550-65
DOI
Related Report
Peer Reviewed
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[Journal Article] Production of monoclonal antibodies against GPCR using cell-free synthesized GPCR antigen and biotinylated liposome-based interaction assay2015
Author(s)
Takeda H, Ogasawara T, Ozawa T, Muraguchi A, Jih PJ, Morishita R, Uchigashima M, Watanabe M, Fujimoto T, Iwasaki T, Endo Y, Sawasaki T
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Journal Title
Sci Rep
Volume: 5
Pages: 11333
DOI
Related Report
Peer Reviewed / Open Access
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