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Neural network regulating olfactory functions in mice

Research Project

Project/Area Number 15K06735
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Nerve anatomy/Neuropathology
Research InstitutionTokyo Medical and Dental University

Principal Investigator

ISHII Tomohiro  東京医科歯科大学, 大学院医歯学総合研究科, 講師 (60549947)

Co-Investigator(Kenkyū-buntansha) 中田 隆夫  東京医科歯科大学, 大学院医歯学総合研究科, 教授 (50218004)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords神経回路 / 発生工学 / 嗅覚
Outline of Final Research Achievements

To understand how sensory information is processed in the brain, it is important to visualize the neural network processing a particular information. We developed novel transgenic mice and tried to visualize neural connections. Modified DNA recombinase Cre molecules are transmitted to neighboring neurons through synaptic connections. We tested if the transsynaptic Cre molecules could induce DNA recombination in neurons neighboring to the target cells, resulting in fluorescent protein expression in these neurons.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (11 results)

All 2018 2016 2015 Other

All Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (7 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results) Remarks (2 results)

  • [Journal Article] Subpopulations of vomeronasal sensory neurons with coordinated coexpression of type 2 vomeronasal receptor genes are differentially dependent on Vmn2r12018

    • Author(s)
      Akiyoshi Sachiko、Ishii Tomohiro、Bai Zhaodai、Mombaerts Peter
    • Journal Title

      European Journal of Neuroscience

      Volume: 47 Issue: 7 Pages: 887-900

    • DOI

      10.1111/ejn.13875

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Light generation of intracellular Ca2+ signals by a genetically encoded protein BACCS2015

    • Author(s)
      Ishii T, Sato K, Kakumoto T, Miura S, Touhara K, Takeuchi S, Nakata T.
    • Journal Title

      Nature Communications

      Volume: 6 Issue: 1

    • DOI

      10.1038/ncomms9021

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 細胞内カルシウムシグナルの光遺伝学ツールBACCS2016

    • Author(s)
      石井智浩、佐藤幸治、中田隆夫
    • Organizer
      第8回光操作研究会
    • Place of Presentation
      慶応大学(東京都・港区)
    • Year and Date
      2016-09-29
    • Related Report
      2016 Research-status Report
  • [Presentation] Light control of intracellular Ca2+ signals by a genetically encoded protein, BACCS2016

    • Author(s)
      Tomohiro Ishii, Koji Sato, Toshiyuki Kakumoto, Shigenori Miura, Kazushige Touhara, Shoji Takeuchi, Takao Nakata
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2016-07-20
    • Related Report
      2016 Research-status Report
  • [Presentation] Optical control of Ca2+ signaling by a synthetic protein BACCS2016

    • Author(s)
      Tomohiro Ishii, Takao Nakata
    • Organizer
      International and Interdisciplinary Symposium 2016 "Towards a New Era of Cardiovascular Research"
    • Place of Presentation
      Tokyo Medical and Dental University(東京都・文京区)
    • Year and Date
      2016-07-11
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] BACCSによる細胞内Ca2+シグナルの光操作とCa2+濃度変化および細胞事象の同時イメージング2016

    • Author(s)
      関詩織、石井智浩、中田隆夫
    • Organizer
      第121回日本解剖学会総会全国学術集会
    • Place of Presentation
      ビッグパレットふくしま(福島県・郡山市)
    • Year and Date
      2016-03-28
    • Related Report
      2015 Research-status Report
  • [Presentation] 細胞内カルシウムシグナルを光によって操作する新規光遺伝学ツールBACCSの開発2016

    • Author(s)
      石井智浩、中田隆夫
    • Organizer
      第121回日本解剖学会総会全国学術集会
    • Place of Presentation
      ビッグパレットふくしま(福島県・郡山市)
    • Year and Date
      2016-03-28
    • Related Report
      2015 Research-status Report
  • [Presentation] 細胞内カルシウムシグナルを光で操作する遺伝学ツールの開発2015

    • Author(s)
      石井智浩、佐藤幸治、角元利行、三浦重徳、東原和成、竹内昌治、中田隆夫
    • Organizer
      BMB2015 第38回日本分子生物学会年会 第88回日本生化学会大会 合同大会
    • Place of Presentation
      神戸ポートアイランド(兵庫県・神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Research-status Report
  • [Presentation] マウス嗅神経細胞における光活性型カルシウムチャネルの発現2015

    • Author(s)
      佐藤幸治、石井智浩、竹内昌治、中田隆夫
    • Organizer
      日本味と匂い学会第49回大会
    • Place of Presentation
      じゅうろくプラザ(岐阜県・岐阜市)
    • Year and Date
      2015-09-24
    • Related Report
      2015 Research-status Report
  • [Remarks] 東京医科歯科大学・細胞生物学分野

    • URL

      http://www.tmd.ac.jp/cbio/index.html

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
  • [Remarks] 東京医科歯科大学プレスリリース

    • URL

      http://www.tmd.ac.jp/archive-tmdu/kouhou/20150819.pdf

    • Related Report
      2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

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