Epigenetic regulation of stem cell aging and organismal aging
Project/Area Number |
15K06835
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Tumor biology
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Research Institution | Kanazawa University (2017) Kyushu University (2015-2016) |
Principal Investigator |
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Co-Investigator(Renkei-kenkyūsha) |
NAKAYAMA Keiichi 九州大学, 生体防御医学研究所, 教授 (80291508)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Keywords | Autism / 幹細胞老化 / 細胞老化 / エピジェネティクス / 発がん / 幹細胞 |
Outline of Final Research Achievements |
We showed that mice heterozygous for Chd8 mutations manifest ASD-like behavioural characteristics including increased anxiety, repetitive behaviour, and altered social behaviour. CHD8 haploinsufficiency did not result in prominent changes in the expression of a few specific genes but instead gave rise to small but global changes in gene expression in the mouse brain, reminiscent of those in the brains of patients with ASD. Gene set enrichment analysis revealed that neurodevelopment was delayed in the mutant mouse embryos. Furthermore, reduced expression of CHD8 was associated with abnormal activation of RE-1 silencing transcription factor (REST), which suppresses the transcription of many neuronal genes. REST activation was also observed in the brains of humans with ASD, and CHD8 was found to interact physically with REST in the mouse brain.
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] The autism-related protein CHD8 cooperates with C/EBPβ to regulate adipogenesis.2018
Author(s)
Kita, Y., Katayama, Y., Shiraishi, T., Oka, T., Sato, T., Suyama, M., Ohkawa, Y., Miyata, K., Oike, Y., Shirane, M., *Nishiyama, M., *Nakayama, K. I.
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Journal Title
Cell Rep.
Volume: -
Pages: -
DOI
Related Report
Peer Reviewed
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[Journal Article] CHD8 haploinsufficiency results in autistic-like phenotypes in mice.2016
Author(s)
Katayama, Y., Nishiyama, M., Shoji, H., Ohkawa, Y., Kawamura, A., Sato, T., Suyama, M., Takumi, T., Miyakawa, T., Nakayama, K. I.
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Journal Title
Nature
Volume: 537
Pages: 675-679
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Presentation] The autism-related gene Chd8 is essential for adipogenesis2017
Author(s)
Kita, Y., Nishiyama, M., Katayama, Y., Miyata, K., Oike, Y., Nakayama, K. I.
Organizer
11th International Symposium of The Institute Network
Place of Presentation
徳島
Year and Date
2017-01-26 – 2017-01-26
Related Report
Int'l Joint Research
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[Presentation] 発生期におけるクロマチンリモデリング異常は自閉症の原因となる2016
Author(s)
片山 雄太, 西山 正章, 昌子 浩孝, 大川 恭行, 川村 敦生, 佐藤 哲也, 須山 幹太, 内匠 透, 宮川 剛, 中山 敬一
Organizer
新学術領域研究(生殖細胞のエピゲノムダイナミクスとその制御、ステムセルエイジングから解明する疾患原理)合同若手育成合宿
Place of Presentation
大分
Year and Date
2016-07-28 – 2016-07-28
Related Report
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[Book] 実験医学2017
Author(s)
片山 雄太,西山 正章,中山 敬一
Total Pages
138
Publisher
羊土社
ISBN
978-4-7581-0159-2
Related Report
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[Book] 分子精神医学2016
Author(s)
川村 敦生, 西山 正章, 中山 敬一
Total Pages
3
Publisher
先端医学社
Related Report
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