Development of novel malignant brain tumor therapy against tumor vascular mimicry derived from tumor cells
| Project/Area Number |
15K06881
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Tumor therapeutics
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| Research Institution | Showa Pharmaceutical University (2016-2017)
Teikyo University (2015) |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 免疫療法 / 腫瘍血管 / 腫瘍擬似血管 / 腫瘍微小環境 / 擬似血管 / 血管新生 / がん免疫 |
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| Outline of Final Research Achievements |
In order to develop a novel therapy for malignant brain tumor with poor efficacy of anti-cancer drugs, attention was paid to blood vessels in cancer tissues, which is a nutrient supply path constructed by cancer cells. That is, since cancer blood vessels are cancer nutrition supply paths, it is a novel method of killing cancer by collapsing cancer vessels. As a fundamental study, I found that cancer cells construct blood vessel like structures on Matrigel. Using the phage-display method, I tried to get the creation of specific antibodies against tumor blood vessels, and I obtained some candidate clones.
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Report
(4 results)
Research Products
(10 results)
