| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
In this study, by using mitochondrial carriers and a lipid, cardiolipine, which is known to interact with the mitochondrial carrier, as a model membrane protein-lipid system, we clarified roles of lipids against the function and structure of the membrane protein. In this study, the effect of cardiolipin on transport activity of yeast and malaria parasite mitochondrial carriers was analyzed. As a result, it was clarified that addition of cardiolipin increases the transport activity of the mitochondrial carriers localized in mitochondrial membrane, but such a effect was not observed in the mitochondrial carriers present in other membrane systems.
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