Research Project
Grant-in-Aid for Scientific Research (C)
Progesterone receptor membrane component 1 (PGRMC1) is a haem-containing protein that interacts with epidermal growth factor receptor (EGFR) and cytochromes P450 to regulate cancer proliferation and chemoresistance; its structural basis remains unknown. Crystallographic analyses revealed that PGRMC1 forms a stable dimer through stacking interactions of two protruding haem molecules. The haem iron is five-coordinated by Tyr113. Haem-mediated PGRMC1 dimerization is required for interactions with EGFR and cytochromes P450, cancer proliferation and chemoresistance against anti-cancer drugs. This study demonstrates protein dimerization via haem-haem stacking, which has not been seen in eukaryotes, and provides insights into its functional significance in cancer.
All 2018 2017 2016 2015 2014 Other
All Int'l Joint Research (2 results) Journal Article (15 results) (of which Int'l Joint Research: 9 results, Peer Reviewed: 14 results, Open Access: 14 results, Acknowledgement Compliant: 4 results) Presentation (4 results) (of which Invited: 2 results)
Nature Communications
Volume: 9 Issue: 1 Pages: 1561-1561
10.1038/s41467-018-03899-1
Scientific Reports
Volume: 7 Issue: 1 Pages: 1019-1019
10.1038/s41598-017-01023-9
Gastroenterology
Volume: S0016-5085 Issue: 6 Pages: 300081-300081
10.1053/j.gastro.2017.01.021
Mol. Cell. Endocrinol.
Volume: 441 Pages: 124-133
10.1016/j.mce.2016.10.014
Mol Cell Endocrinol.
Volume: 441 Pages: 134-139
10.1016/j.mce.2016.07.031
生化学
Volume: 89 Pages: 88-88
40021439299
Endocr. Pathol.
Volume: 28 Issue: 1 Pages: 27-35
10.1007/s12022-016-9441-8
Pharmacological Research
Volume: 117 Pages: 67-71
10.1016/j.phrs.2016.12.023
Free Radical Biology & Medicine
Volume: 99 Pages: 333-344
10.1016/j.freeradbiomed.2016.08.025
Int J Endocrinol.
Volume: 2016 Pages: 7834356-7834356
Arthritis Res Ther.
Volume: 18 Issue: 1 Pages: 112-112
10.1186/s13075-016-1013-2
Volume: 7 Issue: 1 Pages: 11030-11030
10.1038/ncomms11030
130007529314
Microcirculation
Volume: 23 Issue: 3 Pages: 183-190
10.1111/micc.12253
PLoS One
Volume: 10 Issue: 2 Pages: 1-22
10.1371/journal.pone.0118662
Nitric Oxide
Volume: pii: S1089-8603 Pages: 495-499
10.1016/j.niox.2014.11.005