identification of hypothalamic melanin concentrating hormon neural circuit involving sleep reguration.
| Project/Area Number |
15K07140
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Animal physiology/Animal behavior
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| Research Institution | Tokai University |
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Principal Investigator |
Terao Akira 東海大学, 札幌教養教育センター, 教授 (10451402)
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| Co-Investigator(Kenkyū-buntansha) |
岡松 優子 北海道大学, 獣医学研究院, 講師 (90527178)
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| Co-Investigator(Renkei-kenkyūsha) |
YAMANAKA AKIHIRO 名古屋大学, 環境医学研究所, 教授 (60323292)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 睡眠 / 記憶 / 絶食 / 視床下部外側野 / 海馬 / 新規物体認知試験 / 恐怖条件付け試験 / メラニン凝集ホルモン / 長期記憶 / 文脈的恐怖条件付け試験 / MCH / 断眠 |
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| Outline of Final Research Achievements |
Melanin concentrating hormone (MCH) producing neurons project widely throughout the brain, including hippocampus, and control sleep. As sleep is suggested to link to memory and the hippocampus is crucial for memory, possible involvements of MCH neurons in spatial recognition memory formation were examined. MCH neuron ablated mice spent more time for exploration of a novel object relative to a familiar object, compared to the control mice. Moreover, MCH neuron ablated mice given foot-shock-conditioned fear memory showed higher freezing rate than the control mice. On the other hand, MCH neuron ablated mice stayed almost the same time in the center square of open field arena and in the open arms of elevated plus maze, as the control mice. The findings suggest that MCH neurons control hippocampus dependent spatial recognition memory negatively. As MCH neurons are active in sleep period, there is a possibility that MCH neurons delete some memory in sleep.
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Report
(4 results)
Research Products
(15 results)
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[Journal Article] Progesterone dose-dependently modulates hepatocyte growth factor production in 3T3-L1 mouse preadipocytes2017
Author(s)
Ito, T., Yamaji, D., Kamikawa, A., Abd Eldaim, M. A., Okamatsu-Ogura, Y., Terao A., Saito, M., and Kimura, K.
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Journal Title
Endocrine J
Volume: 64
Pages: 777-785
NAID
Related Report
Peer Reviewed
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[Journal Article] Retinoic acid modulates lipid accumulation glucose concentration-dependently through inverse regulation of SREBP-1 expression in 3T3L1 adipocytes2017
Author(s)
Abd Eldaim, M. A., Okamatsu-Ogura, Y., Matsuoka, S., Kamikawa, A, Ahmed, M., M., Terao, A., Nakajima, K., and Kimura, K.
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Journal Title
NAID
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Progressive loss of the orexin neurons reveals dual effects on wakefulness2016
Author(s)
Branch, A. F., Navidi, W., Tabuchi, S., Terao, A., Yamanaka, A., Scammell, T. E., and Behn, C. D.
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Journal Title
Sleep
Volume: 39
Issue: 2
Pages: 369-377
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Presentation] Temporally Controlled Cell-Specific Ablation Of Melanin-Concentrating Hormone (MCH) Neurons Attenuate Non-REM Sleep In Mice2017
Author(s)
Terao, A., Ueno, T., Okamatsu-Ogura, Y., Kimura, K., Tsunematsu T., and Yamanaka, A.
Organizer
31st Annual Meeting of the Associated Professional Sleep Societies
Related Report
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