Understanding the evolutionary dynamics of hair color related genes of small mammals and development of phylogeographicl markers
| Project/Area Number |
15K07177
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biodiversity/Systematics
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| Research Institution | Hokkaido University |
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Principal Investigator |
SUZUKI Hitoshi 北海道大学, 地球環境科学研究院, 教授 (40179239)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 毛色関連遺伝子 / 系統地理学 / Mc1r / Asip / 多重遺伝子族 / ハプロタイプ構造解析 / メラニズム / 毛色変異 / 連鎖不平衡 / 黒目白毛変異 / ハツカネズミ / ヤチネズミ / 腹部特異的プロモーター / 系統地理 / 逆位 / Rattus exulans / Rattus rattus / haplotype structure / recombination / phylogeography / melanism |
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| Outline of Final Research Achievements |
Nuclear DNA haplotype structure analyses in the Japanese wild mice yielded a possible average fragment length of 170 kb of Mus musculus castaneus haplotypes in the M. m. musculus background genome in northern Japan, providing a rough estimate of its elapsed time of 800 generations under an assumption of continued backcrossing. Our analyses showed sporadic appearance of long fragments (2-5 Mb) from the west European subspecies Mus musculus domesticus, indicating contemporary stowaway introduction. In melanistic rats found on Okinawa, a predicted loss-of-function mutation caused by a cysteine to serine amino acid change at p.124C>S (c.370T>A) in the highly conserved functional domain of Asip was suggested to be responsible for the observed melanism. A haplotype structure analysis suggested the possibility of in-situ mutation of the Asip gene within the population on Okinawa.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] Potential cmausativeutation for melanism in rats identified in the agouti signaling protein gene (Asip) of the Rattus rattus species complex on Okinawa Island, Japan2017
Author(s)
Sasamori, S., Wiewel, A. S., Thomson, V. A., Kobayashi, M., Nakata, K., Suzuki, H.
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Journal Title
Zoological Science
Volume: 34
Issue: 6
Pages: 513-522
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Estimation of the evolutionary rates of mitochondrial DNA in two Japanese wood mouse species based on calibrations with Quaternary environmental changes2017
Author(s)
Hanazaki, K., Tomozawa, M., Kinoshita, G., Suzuki, Y., Yamamoto, M., Irino, T., Suzuki, H.
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Journal Title
Zoological Science
Volume: 印刷中
NAID
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Variation in the coat-color-controlling genes, Mc1r and Asip, in the house mouse Mus musculus from Madagascar.2016
Author(s)
Sakuma, Y., Ranorosoa, M. C., Kinoshita, G., Shimoji, H., Tsuchiya, K., Ohdachi, S. D., Arai, S., Tanaka, C., Ramino, H. and Suzuki, H. 2016
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Journal Title
Mammal Study
Volume: 41
Issue: 3
Pages: 131-140
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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