| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Chemical and biological analyses of the chromophore of a photoprotein (pholasin) were performed in order to clarify the detailed structure of the chromophore, and the following results were obtained: 1) 13C-labled dehydrocoelenterazine (DCL) was synthesized. 2) Apo-protein was obtained by cloning and expression of the DNA of the photoprotein. 3) Non-natural DCL analogs, which gave more active substance than natural DCL, were designed and synthesized. From these results, the further progress of this research will be expected.
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