Study on central control of prolactin secretion by salsolinol in ruminants
| Project/Area Number |
15K07685
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Animal production science
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| Research Institution | Iwate University |
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Principal Investigator |
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| Research Collaborator |
György Miklos Nagy Ross University School of Medicine, Department of Anatomy, 教授
Fülöp Ferenc University of Szeged, Institute of Pharmaceutical Chemistry, 教授
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | サルソリノール / プロラクチン / ドーパミン / TRH / ドンペリドン / ハロペリドール / チロシン水酸化酵素 / ヤギ / 反芻家畜 |
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| Outline of Final Research Achievements |
The aim of the present study was to clarify the relationship between hypothalamic dopamine (DA) and salsolinol (SAL) for the secretion of prolactin (PRL) in ruminants. The results obtained from the present studies indicate that the mechanisms underlying the SAL-induced PRL response differ from those of thyrotropin-releasing hormone (TRH), and suggest that the extracerebral DA might be associated in part with the modulation of SAL-induced PRL secretion in goats. The results also indicate that the hypothalamic DA is profoundly involved in the mechanisms of SAL-induced PRL secretion, and suggest that DA and its synthesis by tyrosine hydroxylase is associated in part with SAL-induced PRL secretion.
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Report
(4 results)
Research Products
(15 results)
