Elucidation of immune function through antigen-specific monoclonal T cell receptor
| Project/Area Number |
15K07787
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Integrative animal science
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| Research Institution | University of Yamanashi (2016-2017)
Tokyo Metropolitan Institute of Medical Science (2015) |
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Principal Investigator |
KAMINUMA Osamu 山梨大学, 大学院総合研究部, 准教授 (80342921)
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| Co-Investigator(Kenkyū-buntansha) |
井上 貴美子 国立研究開発法人理化学研究所, 遺伝子工学基盤技術室, 専任研究員 (70360500)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | クローン動物 / T細胞 / 核移植 / T細胞受容体 / アレルギー |
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| Outline of Final Research Achievements |
By comparing cloned mice derived from antigen-specific T cells generated by applicants for the first time and mouse lines developed by crossbreeding of the cloned mice with inbred mice and the same and other cloned mice, we clarified the importance of T cell receptor (TCR) to thymic T cell development and T cell subset differentiation. Antigen-induced T cell responses in T cell cloned mice were stronger than those of corresponding TCR-transgenic mice. Furthermore, the in vivo antigen responses in mice expressing either alpha- or beta-chain of TCR derived from cloned mice were stronger than those of inbred mice. The usefulness of antigen specific T cell cloned mice for investigating immune systems and developing immune disease models.
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] Hyper‐reactive cloned mice generated by direct nuclear transfer of antigen‐specific CD4+ T cells2017
Author(s)
Kaminuma O, Katayama K, Inoue K, Saeki M, Nishimura T, Kitamura N, Shimo Y, Tofukuji S, Ishida S, Ogonuki N, Kamimura S, Oikawa M, Katoh S, Mori A, Shichijo M, Hiroi T, Ogura A
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Journal Title
EMBO reports
Volume: 印刷中
Pages: 885-893
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] Hyper-reactive T cell clone mice as a model for aging study.2016
Author(s)
Osamu Kaminuma, Kimiko Inoue, Mayumi Saeki, Tomoe Nishimura, Noriko Kitamura, Narumi Ogonuki, Satoshi Kamimura, Mami Oikawa, Shigeki Katoh, Akio Mori, Takachika Hiroi, Atsuo Ogura.
Organizer
Frontiers in aging research toward healthy longevity
Place of Presentation
丸の内 MY PLAZA ホール（東京都千代田区）
Year and Date
2016-11-17
Related Report
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