| Project/Area Number |
15K07907
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Physical pharmacy
|
|---|
| Research Institution | Kyoto Pharmaceutical University |
|---|
Principal Investigator |
Hama Susumu 京都薬科大学, 薬学部, 講師 (60438041)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
KOGURE Kentaro 徳島大学, 薬学部, 教授 (70262540)
|
|---|
| Research Collaborator |
HASAN Mahadi
KIRIMURA Naoko
SUZUKI Satoko
NiSHI Takayuki
MATSUI Ryo
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Keywords | ドラッグデリバリーシステム / 腫瘍微小環境 / DDS / 腫瘍内透過 / 核酸 / ドラッグデリバリー / がん微小環境 |
|---|
| Outline of Final Research Achievements |
To develop novel therapeutic procedure for metastatic liver cancer by using tumor microenvironment, in this study, a novel peptide CTR-SAPSP was designed. CTR-SAPSP has tumor permeability and slightly acidic pH-sensitivity. The tumor permeability of nucleic acids carriers modified with CTR-SAPSP was more potent than that of conventional carriers. Moreover, nucleic acids carriers modified with CTR-SAPSP were delivered into the cytoplasm of cells in response to slightly acidic pH. Besides, carriers encapsulating the core composing of siRNA and pH-sensitive peptide SAPSP showed more potent knockdown effect via the effective cytoplasmic release of siRNA. Collectively, nucleic acids carriers equipped with tumor microenvironment-sensitive peptides are expected as a novel therapeutic procedure for metastatic liver cancer.
|
