The role of awareness in learning acquisition during eyeblink conditioning
Project/Area Number |
15K07910
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Physical pharmacy
|
Research Institution | Tokushima Bunri University |
Principal Investigator |
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
|
Keywords | 瞬目反射条件づけ / 意識 / 睡眠 / 条件反射 / 学習 / アルツハイマー病 / 運動学習 / 覚醒 / 自閉症スペクトラム / 覚醒状態 / 記憶学習 / サル / 遺伝子改変マウス |
Outline of Final Research Achievements |
By using eyeblink conditioning, we analyzed the role of awareness/attention on learning acquisition and expression. Experiments in monkeys revealed that latent learning occurred regardless of arousal level, whereas in mice, there was a clear correlation between the arousal state and the expression of conditioned eyeblink responses. We also showed that the perception of surroundings and the degree of attention were strongly correlated with acquisition and expression of learning. By adapting various model animals to this experimental system, we attempted to develop a methodology leading to the development of a therapeutic strategy to overcome neurodegenerative diseases. In this process, we were able to elucidate the physiological role of monoacylglycerol lipase, MDGA1, and MDGA2 in the higher brain functions.
|
Report
(4 results)
Research Products
(31 results)
-
-
[Journal Article] Loss of synapse repressor MDGA1 enhances perisomatic inhibition, confers resistance to network excitation, and impairs cognitive function2017
Author(s)
Steven A. Connor, Ina Ammendrup-Johnsen, Yasushi Kishimoto, Parisa Karimi Tari, Vedrana Cvetkovska, Takashi Harada, Daiki Ojima, Tohru Yamamoto, Yu Tian Wang, Ann Marie Craig
-
Journal Title
Cell Rep.
Volume: 26
Issue: 13
Pages: 3637-3645
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
-
[Journal Article] Altered cortical dynamics and cognitive function upon haploinsufficiency of the autism-linked excitatory synaptic suppressor MDGA22016
Author(s)
S. A. Connor, I. Ammendrup-Johnsen, A. W. Chan, Y. Kishimoto, C. Murayama, N. Kurihara, A. Tada, Y. Ge, H. Lu, R. Yan, J. M. LeDue, H. Matsumoto, H. Kiyonari, Y. Kirino, F. Matsuzaki, T. Suzuki, T. H. Murphy, Y. T. Wang, T. Yamamoto, A. M. Craig
-
Journal Title
Neuron
Volume: 91
Issue: 5
Pages: 1052-1068
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
-
[Journal Article] Data on amyloid precursor protein accumulation, spontaneous physical activity, and motor learning after traumatic brain injury in the triple-transgenic mouse model of Alzheimers disease.2016
Author(s)
Kishimoto Y, Shishido H, Sawanishi M, Toyota Y, Ueno M, Kubota T, Kirino Y, Tamiya T, Kawai N
-
Journal Title
Data Brief.
Volume: pub
Pages: 62-67
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Haploinsufficiency of the neuronal surface protein MDGA2 enhances excitatory synapse development, alters cortical circuit dynamics and yields behavioral phenotypes consistent with autism in mice2016
Author(s)
Connor S.A., Ammendrup-Johnsen I, Chan AW, Kishimoto Y, Murayama C, Kurihara N, Tada A, Ge Y, Yan R, LeDue J, Matsumoto H, Kiyonari H, Kirino Y, Matsuzaki F, Suzuki T, Ojima D, Murphy T.H., Wang Y, Yamamoto T, Craig A
Organizer
Neuroscience 2016 (北米神経科学学会)
Place of Presentation
San Diego, CA, U.S.A.
Year and Date
2016-11-12
Related Report
-
-
-
-
-
-
-
-
-
-
-