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Mechanism of sugar chain elongation catalyzed by muscular dystrophy cause gene product LARGE

Research Project

Project/Area Number 15K07935
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Biological pharmacy
Research InstitutionNagoya City University

Principal Investigator

Yagi Hirokazu  名古屋市立大学, 大学院薬学研究科, 講師 (70565423)

Co-Investigator(Renkei-kenkyūsha) KATO Koichi  名古屋市立大学, 大学院薬学研究科, 教授 (20211849)
SUGIYAMA Masaaki  京都大学, 複合原子力科学研究所, 教授 (10253395)
SATOH Tadashi  名古屋市立大学, 大学院薬学研究科, 准教授 (80532100)
YAMAGUCHI Takumi  北陸先端科学技術大学院大学, マテリアルサイエンス系, 准教授 (60522430)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
KeywordsLARGE / K4CP / 糖転移酵素 / 高速AFM / 糖鎖伸長 / バイファンクショナルな糖転移酵素 / X線小角散乱 / 非変性質量分析 / 筋ジストロフィー
Outline of Final Research Achievements

LARGE (Like-acetylglucosaminyltransferase) is the causative gene product for congenital muscular dystrophy which possesses two catalytic domains with homology to members of glycosyltransferases to form a repeat sequence of xylose and glucuronic acid residues. In this study, we have performed a molecular dynamics study to characterize the mechanism that the enzymes composed of these two catalytic domains catalyze the elongation reactions of sugar chains. As a result, the enzymes exhibited dynamic motions involving domain-domain association and dissociation during the reaction, indicating that orientation between the two domains would contribute to the elongation efficiency to exchange the substrate sugar chain.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (57 results)

All 2018 2017 2016 2015 Other

All Int'l Joint Research (4 results) Journal Article (17 results) (of which Int'l Joint Research: 7 results,  Peer Reviewed: 17 results,  Open Access: 10 results,  Acknowledgement Compliant: 7 results) Presentation (34 results) (of which Int'l Joint Research: 5 results,  Invited: 13 results) Book (1 results) Remarks (1 results)

  • [Int'l Joint Research] Academia Sinica(台湾)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] UMRS1138, University; Paris Descartes,/Institut Laue-Langevin(フランス)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Academia Sinica(Taiwan)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] Albert Einstein College of Medicine(U.S.A.)

    • Related Report
      2016 Research-status Report
  • [Journal Article] Site-specific N-glycosylation analysis of soluble Fcγ receptor IIIb in human serum2018

    • Author(s)
      Yagi Hirokazu、Takakura Daisuke、Roumenina Lubka T.、Fridman Wolf Herman、Sautes-Fridman Catherine、Kawasaki Nana、Kato Koichi
    • Journal Title

      Sci. Rep.

      Volume: 8 Issue: 1 Pages: 2719-2719

    • DOI

      10.1038/s41598-018-21145-y

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Stable isotope labeling approaches for NMR characterization of glycoproteins using eukaryotic expression systems2018

    • Author(s)
      Yanaka Saeko、Yagi Hirokazu、Yogo Rina、Yagi-Utsumi Maho、Kato Koichi
    • Journal Title

      Journal of Biomolecular NMR

      Volume: - Issue: 3 Pages: 1-10

    • DOI

      10.1007/s10858-018-0169-2

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 3D structural analysis of protein O-mannosyl kinase, POMK, a causative gene product of dystroglycanopathy2017

    • Author(s)
      M.Nagae, S.K.Mishra, M.Neyazaki, R.Oi, A.Ikeda, N.Matsugaki, S.Akashi, H.Manya, M.Mizuno, H.Yagi, K.Kato, T.Senda, T.Endo, T.Nogi, and Y.Yamaguchi
    • Journal Title

      Genes Cells

      Volume: - Issue: 4 Pages: 348-359

    • DOI

      10.1111/gtc.12480

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Alteration of a recombinant protein N-glycan structure in silkworms by partial suppression of N-acetylglucosaminidase gene expression2017

    • Author(s)
      Kato Tatsuya、Kikuta Kotaro、Kanematsu Ayumi、Kondo Sachiko、Yagi Hirokazu、Kato Koichi、Park Enoch Y.
    • Journal Title

      Biotechnol. Lett.

      Volume: 39 Issue: 9 Pages: 1299-1308

    • DOI

      10.1007/s10529-017-2361-y

    • NAID

      120006469813

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] NMR Detection of Semi-Specific Antibody Interactions in Serum Environments2017

    • Author(s)
      Yanaka Saeko、Yamazaki Toshio、Yogo Rina、Noda Masanori、Uchiyama Susumu、Yagi Hirokazu、Kato Koichi
    • Journal Title

      Molecules

      Volume: 22 Issue: 10 Pages: 1619-1619

    • DOI

      10.3390/molecules22101619

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Technical Basis for Nuclear Magnetic Resonance Approach for Glycoproteins2017

    • Author(s)
      Kato Koichi、Yanaka Saeko、Yagi Hirokazu
    • Journal Title

      Experimental Approaches of NMR Spectroscopy

      Volume: 1 Pages: 415-438

    • DOI

      10.1007/978-981-10-5966-7_15

    • ISBN
      9789811059650, 9789811059667
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of conformational deformation-coupled interaction between immunoglobulin G1 Fc glycoprotein and a low-affinity Fcγ receptor by deuteration-assisted small-angle neutron scattering2017

    • Author(s)
      Yogo Rina、Yanaka Saeko、Yagi Hirokazu、Martel Anne、Porcar Linoel、Ueki Yutaro、Inoue Rintaro、Sato Nobuhiro、Sugiyama Masaaki、Kato Koichi
    • Journal Title

      Biochemistry and Biophysics Reports

      Volume: 12 Pages: 1-4

    • DOI

      10.1016/j.bbrep.2017.08.004

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Conformational effects of N-glycan core fucosylation of immunoglobulin G Fc region on its interaction with Fcγ receptor IIIa2017

    • Author(s)
      Sakae Yoshitake、Satoh Tadashi、Yagi Hirokazu、Yanaka Saeko、Yamaguchi Takumi、Isoda Yuya、Iida Shigeru、Okamoto Yuko、Kato Koichi
    • Journal Title

      Sci. Rep.

      Volume: 7 Issue: 1 Pages: 13780-13780

    • DOI

      10.1038/s41598-017-13845-8

    • NAID

      120006545940

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Lewis X-Carrying Neoglycolipids Evoke Selective Apoptosis in Neural Stem Cells2017

    • Author(s)
      Yagi Hirokazu、Yan Gengwei、Suzuki Tatsuya、Tsuge Shingo、Yamaguchi Takumi、Kato Koichi
    • Journal Title

      Neurochemical Research

      Volume: 43 Issue: 1 Pages: 212-218

    • DOI

      10.1007/s11064-017-2415-5

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] GlcNAc6ST-1 regulates sulfation of N-glycans and myelination in the peripheral nervous system.2017

    • Author(s)
      Yoshimura T, Hayashi A, Handa-Narumi M, Yagi H, Ohno N, Koike T, Yamaguchi Y, Uchimura K, Kadomatsu K, Sedzik J, Kitamura K, Kato K, Trapp BD, Baba H, Ikenaka K.
    • Journal Title

      Sci Rep.

      Volume: 7 Issue: 1 Pages: 42257-42257

    • DOI

      10.1038/srep42257

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Direct mapping of additional modifications on phosphorylated O-glycans of α-dystroglycan by mass spectrometry analysis in conjunction with knocking out of causative genes for dystroglycanopathy2016

    • Author(s)
      H.Yagi, C.-W.Kuo, T.Obayashi, S.Ninagawa, K.-H.Khoo, and K.Kato
    • Journal Title

      Mol. Cell Proteomics

      Volume: 15 Issue: 11 Pages: 3424-3434

    • DOI

      10.1074/mcp.m116.062729

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Functional roles of glycoconjugates in the maintenance of stemness and differentiation process of neural stem cells2016

    • Author(s)
      Hirokazu Yagi and Koichi Kato
    • Journal Title

      Glycoconjugate J.

      Volume: ‐ Issue: 6 Pages: 1-7

    • DOI

      10.1007/s10719-016-9707-x

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Comparison of analytical methods for profiling N- and O-linked glycans from cultured cell lines : HUPO Human Disease Glycomics/Proteome Initiative multi-institutional study2016

    • Author(s)
      Hiromi Ito et al.
    • Journal Title

      Glycoconjugate J.

      Volume: 未定 Issue: 3 Pages: 405-415

    • DOI

      10.1007/s10719-015-9625-3

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Stable isotope labeling of glycoprotein expressed in silkworms using immunoglobulin G as a test molecule2015

    • Author(s)
      H.Yagi, M.Nakamura, J.Yokoyama, Y.Zhang, T.Yamaguchi, S.Kondo, J.Kobayashi, T.Kato, E.Y.Park, S.Nakazawa, N.Hashii, N.Kawasaki, and K.Kato
    • Journal Title

      J. Biomol. NMR

      Volume: - Issue: 2 Pages: 157-167

    • DOI

      10.1007/s10858-015-9930-y

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Glycan structure and serum half-life of recombinant CTLA4Ig, an immunosuppressive agent, expressed in suspension-cultured rice cells with coexpression of human β1,4-galactosyltransferase and human CTLA4Ig2015

    • Author(s)
      S.H.Kang, H.S.Jung, S.J.Lee1, C.I.Park, S.M.Lim, H.Park, B.S.Kim, K.H.Na, G.J.Han, J.W.Bae, H.J.Park, K.C.Bang, B.T.Park, H.S.Hwang, I.-Soo .Jung, J.I.Kim, D.B.Oh, D.I.Kim, H.Yagi, K.Kato, D.K.Kim, and H.H.Kim
    • Journal Title

      Glycoconjugate J.

      Volume: - Issue: 3-4 Pages: 161-172

    • DOI

      10.1007/s10719-015-9590-x

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Importance of the side chain at position 296 of antibody Fc in interactions with FcγRIIIa and other Fcγ receptors2015

    • Author(s)
      Yuya Isoda, Hirokazu Yagi, Tadashi Satoh, Mami Shibata-Koyama, Kazuhiro Masuda, Mitsuo Satoh,Koichi Kato, and Shigeru Iida
    • Journal Title

      PLoS ONE

      Volume: 10 Issue: 10 Pages: e0140120-e0140120

    • DOI

      10.1371/journal.pone.0140120

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ectopic clustering of Cajal-Retzius and subplate cells is an initial pathological feature in Pomgnt2-knockout mice, a model of dystroglycanopathy2015

    • Author(s)
      Naoki Nakagawa, Hirokazu Yagi, Koichi Kato, Hiromu Takematsu, and Shogo Oka
    • Journal Title

      Sci. Rep.

      Volume: 5 Issue: 1 Pages: 11163-11163

    • DOI

      10.1038/srep11163

    • NAID

      120005670888

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] α-ジストログリカンのラミニン結合性糖鎖形成するポストリン酸修飾の構造解析2017

    • Author(s)
      矢木宏和,Chu-Wei KUO,尾林卓幸,蜷川 暁,Kay-Hooi KHOO,加藤晃一
    • Organizer
      日本薬学会 第137年会
    • Place of Presentation
      東北大学川内北キャンパス(宮城県仙台市)
    • Year and Date
      2017-03-25
    • Related Report
      2016 Research-status Report
  • [Presentation] α-ジストログリカンの上のポストリン酸修飾の構造解析2017

    • Author(s)
      矢木宏和
    • Organizer
      平成28年度 新学術領域「神経糖鎖生物学」最終シンポジウム
    • Place of Presentation
      JPタワー名古屋 ホール&カンファレンス(愛知県名古屋市)
    • Year and Date
      2017-03-03
    • Related Report
      2016 Research-status Report
  • [Presentation] Development and application of glycosylation-profiling techniques for functional glycomics in the nervous system2017

    • Author(s)
      Hirokazu Yagi
    • Organizer
      11th International Symposium on Cell Surface Macromolecules
    • Place of Presentation
      Indian Institute of Science Education and Research (IISER) Mohali(Chandegarh, India)
    • Year and Date
      2017-02-26
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] タンパク質における糖鎖修飾の生物学的機能と高次構造への影響2017

    • Author(s)
      矢木宏和
    • Organizer
      第1回名古屋市立大学若手イブニングセミナー
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 糖タンパク質における糖鎖の生物機能と高次構造への影響2017

    • Author(s)
      矢木宏和
    • Organizer
      第58回 日本生化学会中国四国支部例会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] FUT9によるキャリアタンパク質特異的なフコース修飾機構の解明2017

    • Author(s)
      齋藤泰輝,矢木宏和,柘植信吾,Chuwei Kuo,Kay-Hooi Khoo,加藤晃一
    • Organizer
      第81回 日本生化学会中部支部例会・シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] フコース転移酵素によるキャリアタンパク質特異的なLewisX修飾機構2017

    • Author(s)
      矢木宏和,齋藤泰輝,姫田美咲,柘植信吾,加藤晃一
    • Organizer
      第69回日本細胞生物学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 糖タンパク質糖鎖の機能解明のための構造解析技術の開発と応用2017

    • Author(s)
      矢木宏和
    • Organizer
      第1回触発型有機化学研究会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] The characterization of the laminin-binding glycans on alpha-dystroglycan catalyzed by several causative gene products of dystroglycanopathy2017

    • Author(s)
      Hirokazu Yagi
    • Organizer
      The 1st International Conference on the Glycobiology of Nervous System
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Mechanisms underlying the carrier protein-specific lewis X modification catalyzed by fucosyltransferase IX2017

    • Author(s)
      Taiki Saito, Hirokazu Yagi, Shingo Tsuge, Chuwei Kuo, Kay-Hooi Khoo, and Koichi Kato
    • Organizer
      The 1st International Conference on the Glycobiology of Nervous System
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 糖タンパク質糖鎖の構造解析法の開発と糖鎖機能解析への応用2017

    • Author(s)
      矢木宏和
    • Organizer
      第2回G-CHAINセミナー
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 糖タンパク質糖鎖の機能解明のための構造生物学的アプローチ法の開発と応用2017

    • Author(s)
      矢木宏和
    • Organizer
      第26回 日本バイオイメージング学会学術集会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] α-ジストログリカンに発現するホスホジエステル結合を有する糖鎖の構造機能解析2017

    • Author(s)
      尾林卓幸,矢木宏和,Chu-Wei Kuo,蜷川 暁,Kay-Hooi Khoo,加藤晃一
    • Organizer
      第14回「若手の力フォーラム」
    • Related Report
      2017 Annual Research Report
  • [Presentation] フコース転移酵素9によるキャリアタンパク質特異的なフコース修飾機構の解明2017

    • Author(s)
      齋藤泰輝,矢木宏和,Chu-Wei Kuo,Kay-Hooi Khoo,加藤晃一
    • Organizer
      第14回「若手の力フォーラム」
    • Related Report
      2017 Annual Research Report
  • [Presentation] フコース転移酵素のキャリアタンパク質に対する特異的なLewisX修飾機構2017

    • Author(s)
      矢木宏和,齋藤泰輝,姫田美咲,柘植信吾,加藤晃一
    • Organizer
      2017年度 生命科学系学会合同年次大会(ConBio2017)
    • Related Report
      2017 Annual Research Report
  • [Presentation] キャリアータンパク質特異的なLewisX糖鎖修飾機構の解析2016

    • Author(s)
      柘植信吾,姫田美咲,矢木宏和,加藤晃一
    • Organizer
      糖鎖科学中部拠点 第13回「若手の力」フォーラム
    • Place of Presentation
      岐阜大学(岐阜県岐阜市)
    • Year and Date
      2016-11-26
    • Related Report
      2016 Research-status Report
  • [Presentation] 2つの異なる転移活性ドメインを有する糖転移酵素による糖鎖伸長機構の解析2016

    • Author(s)
      金 明美,吉田早希,小財稔矢,内橋貴之,杉山正明,矢木宏和,加藤晃一
    • Organizer
      糖鎖科学中部拠点 第13回「若手の力」フォーラム
    • Place of Presentation
      岐阜大学(岐阜県岐阜市)
    • Year and Date
      2016-11-26
    • Related Report
      2016 Research-status Report
  • [Presentation] 細胞膜上の糖鎖の機能解明のための糖鎖クラスターの設計と創生2016

    • Author(s)
      矢木宏和
    • Organizer
      第38回 生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      名古屋市立大学薬学部 宮田専治記念ホール(愛知県名古屋市)
    • Year and Date
      2016-11-17
    • Related Report
      2016 Research-status Report
  • [Presentation] キャリア依存的なLewisX糖鎖修飾を担う特異的なゴルジ体の局在2016

    • Author(s)
      姫田美咲,柘植信吾,矢木宏和,加藤晃一
    • Organizer
      第25回 日本バイオイメージング学会学術集会
    • Place of Presentation
      名古屋市立大学薬学部 宮田専治記念ホール(愛知県名古屋市)
    • Year and Date
      2016-09-05
    • Related Report
      2016 Research-status Report
  • [Presentation] ヒト血清由来の可溶型FcγレセプターIIIbの部位特異的なN型糖鎖の構造解析2016

    • Author(s)
      矢木宏和,高倉大輔,Lubka T. Roumenina,Wolf Herman Fridman,Catherine Sautes-Fridman,川崎ナナ,加藤晃一
    • Organizer
      第35回 日本糖質学会年会
    • Place of Presentation
      高知市文化プラザ かるぽーと(高知県高知市)
    • Year and Date
      2016-09-03
    • Related Report
      2016 Research-status Report
  • [Presentation] 分子、細胞、組織レベルにおける糖鎖の機能解析2016

    • Author(s)
      矢木宏和
    • Organizer
      日本大学理工学部インフォーマルセミナー
    • Place of Presentation
      日本大学理工学部(東京)
    • Year and Date
      2016-01-22
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Functional analysis of causative gene products of α-dystroglycanopaty associated with the formation of laminin-binding glycans2016

    • Author(s)
      Hirokazu Yagi
    • Organizer
      The 3rd International Symposium on Glyco-Neuroscience
    • Place of Presentation
      淡路夢舞台(淡路)
    • Year and Date
      2016-01-15
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Extracellular O-GlcNAc regulates Dll4-dependent Notch signaling in the endothelial cells and BBB/BRB maintenance2016

    • Author(s)
      Mitsutaka Ogawa, Shogo Sawaguchi, Kyosuke Takeshita, Toyoaki Murohara, Hirokazu Yagi, Koichi Kato, Koichi Furukawa, and Tetsuya Okajima
    • Organizer
      The 3rd International Symposium on Glyco-Neuroscience
    • Place of Presentation
      淡路夢舞台(淡路)
    • Year and Date
      2016-01-14
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Extracellular O-GlcNAc modification regulates Notch signaling and blood-retina barrier maintenance2015

    • Author(s)
      小川光貴,澤口翔伍,Bieniasz-Krzywiec Pawel,矢木宏和,加藤晃一,臼倉治郎,古川鋼一,岡島徹也
    • Organizer
      第38回日本分子生物学会年会、第88回日本生化学会大会 合同大会(BMB2015)
    • Place of Presentation
      神戸ポートアイランド(神戸)
    • Year and Date
      2015-12-03
    • Related Report
      2015 Research-status Report
  • [Presentation] 細胞外 O-GlcNAc の修飾に関わる EOGT 変異マウスの表現型解析2015

    • Author(s)
      澤口翔伍、小川光貴、矢木宏和、加藤晃一、臼倉治郎、古川鋼一、岡島徹也
    • Organizer
      第38回日本分子生物学会年会、第88回日本生化学会大会 合同大会(BMB2015)
    • Place of Presentation
      神戸ポートアイランド(神戸)
    • Year and Date
      2015-12-03
    • Related Report
      2015 Research-status Report
  • [Presentation] Functional analysis of enzymes involved in the formation of laminin-binding glycans displayed on α-dystroglycan2015

    • Author(s)
      Hirokazu Yagi and Koichi Kato
    • Organizer
      第38回日本分子生物学会年会、第88回日本生化学会大会 合同大会(BMB2015)
    • Place of Presentation
      神戸ポートアイランド(神戸)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 硫酸化糖鎖は末梢神経系髄鞘の形成を制御する2015

    • Author(s)
      吉村 武,半田(鳴海)麻衣,林 明子,矢木宏和,内村健治,門松健治、加藤晃一,Bruce D. Trapp,馬場広子,池中一裕
    • Organizer
      糖鎖科学中部拠点第12回「若手の力」フォーラム
    • Place of Presentation
      名城大学薬学部(名古屋)
    • Year and Date
      2015-11-28
    • Related Report
      2015 Research-status Report
  • [Presentation] 細胞外O-GlcNAcの修飾に関わるEOGT変異マウスの表現形解析2015

    • Author(s)
      Shogo Sawaguchi, Mitsutaka Ogawa, Hirokazu Yagi, Koichi Kato, Jiro Usukura, Koichi Furukawa, and Tetsuya Okajima
    • Organizer
      糖鎖科学中部拠点第12回「若手の力」フォーラム
    • Place of Presentation
      名城大学薬学部(名古屋)
    • Year and Date
      2015-11-28
    • Related Report
      2015 Research-status Report
  • [Presentation] Application of N-glycosylation profiling by using HPLC mapping2015

    • Author(s)
      Hirokazu Yagi
    • Organizer
      糖鎖科学中部拠点/日本ウォーターズ共催セミナー
    • Place of Presentation
      ウインクあいち(名古屋)
    • Year and Date
      2015-08-03
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] GlcNAc6ST-1 は N 結合型糖鎖の硫酸化を介して末梢神経系の髄鞘形成を制御する2015

    • Author(s)
      吉村 武,林 明子,内村健治,門松健治,矢木宏和,加藤晃一,馬場広子,池中一裕
    • Organizer
      第34回日本糖質学会年会
    • Place of Presentation
      東京大学(東京)
    • Year and Date
      2015-08-02
    • Related Report
      2015 Research-status Report
  • [Presentation] 神経系における糖鎖の機能解明のための糖鎖プロファイリング技術の開発とその応用2015

    • Author(s)
      矢木宏和
    • Organizer
      第34回日本糖質学会年会
    • Place of Presentation
      東京大学(東京)
    • Year and Date
      2015-08-01
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Biological roles of extracellular O-GlcNAc in Notch signaling,vascular development,and blood retinal barrier maintenance2015

    • Author(s)
      Mitsutaka Ogawa, Shogo Sawaguchi, Pawel Bieniasz-Krzywiec, Hirokazu Yagi, Koichi Kato, Jiro Usukura, Koichi Furukawa, and Tetsuya Okajima
    • Organizer
      第79回日本生化学会中部支部例会
    • Place of Presentation
      信州大学松本キャンパス(松本)
    • Year and Date
      2015-05-23
    • Related Report
      2015 Research-status Report
  • [Presentation] 細胞外O-GlcNAcの修飾に関わるEOGT変異マウスの表現型解析2015

    • Author(s)
      Shogo Sawaguchi, Mitsutaka Ogawa, Hirokazu Yagi, Koichi Kato, Jiro Usukura, Koichi Furukawa, and Tetsuya Okajima
    • Organizer
      第79回日本生化学会中部支部例会
    • Place of Presentation
      信州大学松本キャンパス(松本)
    • Year and Date
      2015-05-23
    • Related Report
      2015 Research-status Report
  • [Presentation] HPLCおよび質量分析による糖鎖の構造解析2015

    • Author(s)
      矢木宏和
    • Organizer
      技術情報協会セミナー「バイオ/抗体医薬品における糖鎖・タンパク質解析の 基礎とバリデーション」
    • Place of Presentation
      技術情報協会(東京)
    • Year and Date
      2015-05-19
    • Related Report
      2015 Research-status Report
    • Invited
  • [Book] 糖鎖の新機能開発・応用ハンドブック~創薬・医療から食品開発まで~2015

    • Author(s)
      矢木宏和,加藤晃一
    • Total Pages
      6
    • Publisher
      ㈱エヌ・ティー・エス
    • Related Report
      2015 Research-status Report
  • [Remarks] 研究室ホームページ

    • URL

      http://www.phar.nagoya-cu.ac.jp/hp/sbk/kenkyu/index.html

    • Related Report
      2016 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2022-08-18  

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