| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
The expression of COX-2, mPGES-1 and EP3 receptors were increased in hippocampus of kainic acid (KA)-induced seizure mice. The seizure score and hippocampal neurotoxicity in EP3 knockout (KO) mice was significantly lower than that in wild-type (WT) mice. The glial activation and inflammatory responses after seizures were also less severe in EP3KO mice as compared with WT mice. These results suggest that activation of EP3 receptors after KA injection contributes to seizure susceptibility, glial activation and hippocampal neuronal loss. Thus, inhibition of EP3 receptors will be a valuable therapeutic option in treatment of temporal lobe epilepsy.
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