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Search for new therapeutic candidates for aimed to overcoming of inflammatory bowel diseases

Research Project

Project/Area Number 15K08008
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Natural medicines
Research InstitutionKindai University

Principal Investigator

MORIKAWA Toshio  近畿大学, 薬学総合研究所, 教授 (10340449)

Co-Investigator(Renkei-kenkyūsha) NINOMIYA Kiyofumi  近畿大学, 薬学総合研究所, 准教授 (10434862)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords難治性炎症性疾患治療薬シーズ / 伝承・伝統薬物資源探索 / 一酸化窒素 / TNF-α / iNOS / Carapa guianensis / Myristica fragrans / Shorea roxburghii / 乳香 / 没薬 / 人参果 / メース / Chimonanthus praecox / CCR3 アンタゴニスト活性 / リモノイド / オリゴスチルベノイド / Mammea siamensis / Melodorum fruticosum / Nelumbo nucifera / Cnidium officinale / アロエ
Outline of Final Research Achievements

To explore new therapeutic candidates for aimed to overcoming of inflammatory bowel diseases from traditional natural resources worldwide, we searched for active constituents that regulate several inflammation reactions caused by over productions of NO and TNF-alfa etc in iNOS-positive cells. As the results, several constituents from the natural resources were investigated as the promissing candidates and their structural requirements and the mode of action were suggested.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (142 results)

All 2018 2017 2016 2015 Other

All Int'l Joint Research (6 results) Journal Article (30 results) (of which Int'l Joint Research: 11 results,  Peer Reviewed: 28 results,  Open Access: 8 results,  Acknowledgement Compliant: 11 results) Presentation (105 results) (of which Int'l Joint Research: 19 results,  Invited: 2 results) Remarks (1 results)

  • [Int'l Joint Research] Rajamangala University(タイ)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Beijing University of Chinese Medicine(中国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] ラジャマンガラ工科大学(タイ)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] 台湾国立中国医薬研究所(台湾)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] ラジャマンガラ工科大学(タイ)

    • Related Report
      2015 Research-status Report
  • [Int'l Joint Research] 台湾国立中国医薬研究所(台湾)

    • Related Report
      2015 Research-status Report
  • [Journal Article] Degranulation inhibitors from the arils of Myristica fragrans in antigen-stimulated rat basophilic leukemia cells2018

    • Author(s)
      Morikawa T., Hachiman I., Ninomiya K., Hata H., Sugawara K., Muraoka O., Matsuda H.
    • Journal Title

      Journal of Natural Medicines

      Volume: 72 Issue: 2 Pages: 464-473

    • DOI

      10.1007/s11418-017-1170-x

    • NAID

      40021511355

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Total syntheses of the aromatase inhibitors, mammeasins C and D, from Thai medicinal plant Mammea siamensis2017

    • Author(s)
      Tanabe G., Tsutsui N., Shibatani K., Marumoto S., Ishikawa F., Ninomiya K., Muraoka O., Morikawa T.
    • Journal Title

      Tetrahedron

      Volume: 73 Issue: 30 Pages: 4481-4486

    • DOI

      10.1016/j.tet.2017.06.016

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Review of Anti-inflammatory Terpenoids from the Incense Gum Resins Frankincense and Myrrh2017

    • Author(s)
      Morikawa T., Matsuda H., Yoshikawa M.
    • Journal Title

      Journal of Oleo Science

      Volume: 66 Issue: 8 Pages: 805-814

    • DOI

      10.5650/jos.ess16149

    • NAID

      130005875884

    • ISSN
      1345-8957, 1347-3352
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 薬学領域からの機能性食品素材開発―サラシアの抗糖尿病効果―2017

    • Author(s)
      森川敏生
    • Journal Title

      大阪府薬雑誌

      Volume: 68 Pages: 51-58

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 生薬・薬用植物研究が明らかにする漢方の実力 カンカニクジュヨウ(Cistanche tubulosa)の耐糖能改善作用成分2017

    • Author(s)
      森川敏生
    • Journal Title

      月刊ファインケミカル

      Volume: 46 Pages: 13-19

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Melanogenesis inhibitory activity of diterpenoid and triterpenoid constituents from the aerial part of Isodon trichocarpus2017

    • Author(s)
      Manse Y., Ninomiya K., Okazak, A., Okada-Nishida E., Imagawa T., Imamura-Mizushima M., Yamano Y., Kaname K., Nakamura S., Morikawa T.
    • Journal Title

      Natural Product Communications

      Volume: 12 Pages: 1185-1188

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Major constituents of Cistanche tubulosa , echinacoside and acteoside, inhibit sodium-dependent glucose cotransporter 1-mediated glucose uptake by intestinal epithelial cells2017

    • Author(s)
      Shimada H., Urabe Y., Okamoto Y., Li Z., Kawase A., Morikawa T., Tu P., Muraoka O., Iwaki M.
    • Journal Title

      Jouranl of Functional Foods

      Volume: 39 Pages: 91-95

    • DOI

      10.1016/j.jff.2017.10.013

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Ergostane-Type Sterols from King Trumpet Mushroom (Pleurotus eryngii) and Their Inhibitory Effects on Aromatase2017

    • Author(s)
      Kikuchi T., Motoyashiki N., Yamada T., Shibatani K., Ninomiya K., Morikawa T., Tanaka R.
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 18 Issue: 11 Pages: 2479-2479

    • DOI

      10.3390/ijms18112479

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Labdane-Type Diterpenes, Galangalditerpenes A?C, with Melanogenesis Inhibitory Activity from the Fruit of Alpinia galanga2017

    • Author(s)
      Manse Y., Ninomiya K., Nishi R., Hashimoto Y., Chaipech S., Muraoka Osamu、Morikawa Toshio
    • Journal Title

      Molecules

      Volume: 22 Issue: 12 Pages: 2279-2279

    • DOI

      10.3390/molecules22122279

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Diastereoselective Synthesis of Salacinol-Type α-Glucosidase Inhibitors2017

    • Author(s)
      Ishikawa Fumihiro、Jinno Kazumi、Kinouchi Eri、Ninomiya Kiyofumi、Marumoto Shinsuke、Xie Weijia、Muraoka Osamu、Morikawa Toshio、Tanabe Genzoh
    • Journal Title

      Journal of Organic Chemistry

      Volume: 83 Issue: 1 Pages: 185-193

    • DOI

      10.1021/acs.joc.7b02566

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Ellagic acid glycosides with hepatoprotective activity from traditional Tibetan medicine Potentilla anserina2017

    • Author(s)
      Morikawa T., Imura K., Akagi Y., Muraoka O., Ninomiya K.
    • Journal Title

      Journal of Natural Medicines

      Volume: 72 Issue: 1 Pages: 317-325

    • DOI

      10.1007/s11418-017-1137-y

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Two new aromatic glycosides, elengiosides A and B, from the flowers of Mimusops elengi2017

    • Author(s)
      Morikawa T., Manse Y., Koda M., Chaipech S., Pongpiriyadacha Y., Muraoka O., Ninomiya K.
    • Journal Title

      Journal of Natural Medicines

      Volume: 72 Issue: 2 Pages: 542-550

    • DOI

      10.1007/s11418-017-1160-z

    • NAID

      40021511451

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Quantitative determination of stilbenoids and dihydroisocoumarins in Shorea roxburghii and evaluation of their hepatoprotective activity2017

    • Author(s)
      Ninomiya K., Chaipech S., Kunikata Y., Yagi R., Pongpiriyadacha Y., Muraoka O., Morikawa T.
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 18 Issue: 2 Pages: 451-451

    • DOI

      10.3390/ijms18020451

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Phenylethanoid and phenylpropanoid glycosides with melanogenesis inhibitory activity from the flowers of Narcissus tazetta var. chinensis2016

    • Author(s)
      Morikawa T., Ninomiya K., Kuramoto H., Kamei I., Yoshikawa M., Muraoka O.
    • Journal Title

      Journal of Natural Medicines

      Volume: 70 Issue: 1 Pages: 89-101

    • DOI

      10.1007/s11418-015-0941-5

    • NAID

      40020680941

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Simultaneous quantitative analysis of 12 methoxyflavones with melanogenesis inhibitory activity from the rhizomes of Kaempferia parviflora2016

    • Author(s)
      Ninomiya K., Matsumoto T., Chaipech S., Miyake S., Katsuyama Y., Tsuboyama A., Pongpiriyadacha Y., Hayakawa T., Muraoka O., Morikawa T.
    • Journal Title

      Journal of Natural Medicines

      Volume: 70 Issue: 2 Pages: 179-189

    • DOI

      10.1007/s11418-015-0955-z

    • NAID

      40020758206

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Hepatoprotective limonoids from andiroba (Carapa guianensis)2016

    • Author(s)
      Ninomiya K., Miyazawa S., Ozeki K., Matsuo N., Muraoka O., Kikuchi T., Yamada T., Tanaka R., Morikawa T.
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 17 Issue: 4 Pages: 591-591

    • DOI

      10.3390/ijms17040591

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Efficient use of a crude drug/herb library reveals Ephedra Herb as a specific antagonist for Th2-specific chemokine receptors CCR3, CCR4, and CCR82016

    • Author(s)
      Matsuo K, Koizumi K, Fujita M, Morikawa T, Jo M, Shibahara N, Saiki I, Yoshie O, Nakayama T
    • Journal Title

      Front. Cell Dev. Biol.

      Volume: 4 Pages: 54-54

    • DOI

      10.3389/fcell.2016.00054

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Aromatase Inhibitory Activity of Geranylated Coumarins, Mammeasins C and D, Isolated from the Flowers of <i>Mammea siamensis</i>2016

    • Author(s)
      Ninomiya K., Shibatani K., Sueyoshi M., Chaipech S., Pongpiriyadacha Y., Hayakawa T., Muraoka O., Morikawa T.
    • Journal Title

      Chemical and Pharmaceutical Bulletin

      Volume: 64 Issue: 7 Pages: 880-885

    • DOI

      10.1248/cpb.c16-00218

    • NAID

      130005160025

    • ISSN
      0009-2363, 1347-5223
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Acylated oleanane-type triterpene saponins from the flowers of Bellis perennis show anti-proliferative activities against human digestive tract carcinoma cell lines2016

    • Author(s)
      Ninomiya K., Motai C., Nishida E., Kitagawa N., Yoshihara K., Hayakawa T., Muraoka O., Li X., Nakamura S., Yoshikawa M., Matsuda H., Morikawa T.
    • Journal Title

      Journal of Natural Medicines

      Volume: 70 Issue: 3 Pages: 435-451

    • DOI

      10.1007/s11418-016-0998-9

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] New biofunctional effects of the flower buds of Camellia sinensis and its bioactive acylated oleanane-type triterpene oligoglycosides2016

    • Author(s)
      Hisashi Matsuda, Seikou Nakamura, Toshio Morikawa, Osamu Muraoka, Masayuki Yoshikawa
    • Journal Title

      Journal of Natural Medicines

      Volume: 70 Issue: 4 Pages: 689-701

    • DOI

      10.1007/s11418-016-1021-1

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Quantitative determination of alkaloids in lotus flower (flower buds of Nelumbo nucifera) and their melanogenesis inhibitoy activity2016

    • Author(s)
      Morikawa T., Kitagawa N., Tanabe G., Ninomiya K., Okugawa S., Motai C., Kamei I., Yoshikawa M., Lee I-J., Muraoka O.
    • Journal Title

      Molecules

      Volume: 21 Issue: 7 Pages: 930-930

    • DOI

      10.3390/molecules21070930

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Quantitative determination of principal alkaloid and flavonoid constituents in wintersweet, the flower buds of Chimonanthus praecox2016

    • Author(s)
      Kitagawa N., Ninomiya K., Okugawa S., Motai C., Nakanishi Y., Yoshikawa M., Muraoka O., Morikawa T.
    • Journal Title

      Natural Product Communications

      Volume: 11 Pages: 953-956

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Neolignanes from aril of Myristica fragrans as potent antagonists of CC chemokine receptor 32016

    • Author(s)
      Morikawa T, Hachiman I, Matsuo K, Nishida E, Ninomiya K, Hayakawa T, Yoshie O, Muraoka O, Nakayama T
    • Journal Title

      J. Nat. Prod.

      Volume: 79 Issue: 8 Pages: 2005-2013

    • DOI

      10.1021/acs.jnatprod.6b00262

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Inhibitory Effects of Oligostilbenoids from the Bark of <i>Shorea roxburghii</i> on Malignant Melanoma Cell Growth: Implications for Novel Topical Anticancer Candidates2016

    • Author(s)
      Moriyama H, Moriyama M, Ninomiya K, Morikawa T, Hayakawa T.
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 39 Issue: 10 Pages: 1675-1682

    • DOI

      10.1248/bpb.b16-00420

    • NAID

      130005598499

    • ISSN
      0918-6158, 1347-5215
    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Melanogenesis inhibitory activity of a 7-O-9'-linked neolignan from Alpinia galanga fruit2016

    • Author(s)
      Manse Y., Ninomiya K., Nishi R., Kamei I., Katsuyama Y., Imagawa T., Chipech S., Muraoka O., Morikawa T.
    • Journal Title

      Bioorganic and Medicinal Chemistry

      Volume: 24 Issue: 23 Pages: 6215-6224

    • DOI

      10.1016/j.bmc.2016.10.001

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] The antiproliferative effect of chakasaponins I and II, floratheasaponin A, and epigallocatechin 3-O-gallate isolated from Camella sinensis on human digestive tract carcinoma cell lines2016

    • Author(s)
      Kitagawa N., Morikawa T., Motai C., Ninomiya K., Okugawa S., Nishida A., Yoshikawa M., Muraoka O.
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 17 Issue: 12 Pages: 1979-1979

    • DOI

      10.3390/ijms17121979

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Andirolides W-Y from the flower oil of andiroba (Carapa guianensis, Meliaceae)2015

    • Author(s)
      Sakamoto A., Tanaka Y., Yamada T., Kikuchi T., Muraoka O., Ninomiya K., Morikawa T., Tanaka R.
    • Journal Title

      Fitoterapia

      Volume: 100 Pages: 81-87

    • DOI

      10.1016/j.fitote.2014.09.003

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Carapanolides M-S from seeds of andiroba (Carapa guianensis, Meliaceae) and triglyceride metabolism-promoting activity in high glucose-pretreated HepG2 cells2015

    • Author(s)
      Inoue T., Matsui Y., Kikuchi T., Yamada T., In Y., Muraoka O., Sakai C., Ninomiya K., Morikawa T., Tanaka R.
    • Journal Title

      Tetrahedron

      Volume: 71 Issue: 18 Pages: 2753-2760

    • DOI

      10.1016/j.tet.2015.03.017

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Total synthesis of 4,5-didehydroguadiscine: a potent melanogenesis inhibitor from the Brazilian medicinal herb, Hornschuchia oblique2015

    • Author(s)
      Tanabe G., Sugano Y., Shirato M., Sonoda N., Tsutsui N., Morikawa T., Ninomiya K., Yoshikawa M., Muraoka O.
    • Journal Title

      Journal of Natural Medicines

      Volume: 78 Issue: 7 Pages: 1536-1542

    • DOI

      10.1021/np500995z

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Dipeptidyl peptidase-IV inhibitory activity of dimeric dihydrochalcone glycosides from flowers of Helichrysum arenarium2015

    • Author(s)
      Morikawa T., Ninomiya K., Akaki J., Kakihara N., Kuramoto H., Matsumoto Y., Hayakawa T., Muraoka O., Wang L.-B., Wu L.-J., Nakamura S., Yoshikawa M., Matsuda H.
    • Journal Title

      Journal of Natural Medicines

      Volume: 69 Pages: 494-506

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] マツリカ (Jasminum sambac, 花部) のアロマターゼ阻害活性成分2018

    • Author(s)
      井上尚樹,二宮清文,柴谷華苗,佐々木佑人,吉川雅之,村岡 修,森川敏生
    • Organizer
      日本農芸化学会 2018 年度大会(名古屋),2018.3.15-18.
    • Related Report
      2017 Annual Research Report
  • [Presentation] タイ天然薬物 Mammea siamensis 花部の新規プレニルクマリン成分とがん細胞増殖抑制活性2018

    • Author(s)
      杉田秀美,二宮清文,村木謙一,佐伯竣介,Chaipech Saowanee,Pongpiriyadacha Yutana,村岡 修,森川敏生
    • Organizer
      日本農芸化学会 2018 年度大会(名古屋),2018.3.15-18.
    • Related Report
      2017 Annual Research Report
  • [Presentation] ローズヒップエキスおよび trans-tiliroside が肝細胞内脂質代謝におよぼす影響2018

    • Author(s)
      長友暁史,二宮清文,松本亜衣,児玉高幸,川上宏智,吉川雅之,村岡 修,森川敏生
    • Organizer
      日本農芸化学会 2018 年度大会(名古屋),2018.3.15-18.
    • Related Report
      2017 Annual Research Report
  • [Presentation] 釣藤鈎 (Uncaria rhynchophylla, 鈎部) 由来トリテルペン成分の神経様突起胃伸長作用2018

    • Author(s)
      菅原 碧,二宮清文,河端千尋,今野拓哉,南野 亨,森川敏生
    • Organizer
      日本農芸化学会 2018 年度大会(名古屋),2018.3.15-18.
    • Related Report
      2017 Annual Research Report
  • [Presentation] 川&#33422; (Cnidium officinale, 根茎) の糖代謝改善作用成分2018

    • Author(s)
      宮坂賢知,二宮清文,二宮 与,酒井千恵,塩谷美幸,森川敏生
    • Organizer
      日本農芸化学会 2018 年度大会(名古屋),2018.3.15-18.
    • Related Report
      2017 Annual Research Report
  • [Presentation] 生活習慣病の予防・改善に資する機能性食品成分の探索2018

    • Author(s)
      森川敏生,村岡 修
    • Organizer
      日本薬学会第 138 年会(金沢),2018.3.25-28.
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] タイ天然薬物 Mammea siamensis 花部含有クマリン成分のアロマターゼ阻害活性2018

    • Author(s)
      二宮清文,柴谷華苗,末吉真弓,Chaipech Saowanee,Pongpiriyadacha Yutana,村岡 修,森川敏生
    • Organizer
      日本薬学会第 138 年会(金沢),2018.3.25-28.
    • Related Report
      2017 Annual Research Report
  • [Presentation] メース (Myristica fragrans Houtt., 仮種皮) 含有ネオリグナン成分の糖消費促進活性2018

    • Author(s)
      二宮清文,宮坂賢知,八幡郁子,村岡 修,森川敏生
    • Organizer
      日本薬学会第 138 年会(金沢),2018.3.25-28.
    • Related Report
      2017 Annual Research Report
  • [Presentation] サイコ (Bupleurum falcatum L.) 含有サポニン成分の抗 TNF-α 作用2018

    • Author(s)
      二宮清文,赤木 駿,今野拓哉,森川敏生
    • Organizer
      日本薬学会第 138 年会(金沢),2018.3.25-28.
    • Related Report
      2017 Annual Research Report
  • [Presentation] 加齢に伴う内臓脂肪蓄積に対する防風通聖散の効果2018

    • Author(s)
      赤木淳二,荒井哲也,和田篤敬,山崎寛生,二宮清文,森川敏生
    • Organizer
      日本薬学会第 138 年会(金沢),2018.3.25-28.
    • Related Report
      2017 Annual Research Report
  • [Presentation] タイ天然薬物 Melodorum fruticosum 由来 NO 産生抑制活性 Butenolide 類の合成およびその活性評価2017

    • Author(s)
      田邉元三,森川敏生,福田梨沙,福田友紀,萬瀬貴昭,二宮清文,松本朋子,眞野みのり,松田久司,村岡 修
    • Organizer
      日本薬学会第 137 年会
    • Place of Presentation
      仙台国際センター(仙台)
    • Year and Date
      2017-03-24
    • Related Report
      2016 Research-status Report
  • [Presentation] Chakasaponin 類のヒト消化管由来がん細胞に対する細胞増殖抑制活性の構造活性相関2017

    • Author(s)
      二宮清文,甕 千明,西田文香,奥川修平,北川仁一朗,吉川雅之,村岡 修,森川敏生
    • Organizer
      日本薬学会第 137 年会
    • Place of Presentation
      仙台国際センター(仙台)
    • Year and Date
      2017-03-24
    • Related Report
      2016 Research-status Report
  • [Presentation] ブラジル生薬 Carapa guianensis 含有リモノイド成分の肝保護作用2017

    • Author(s)
      二宮清文,宮澤聖也,尾関快天,松尾菜都子,村岡 修,菊池 崇,山田剛司,田中麗子,森川敏生
    • Organizer
      日本薬学会第 137 年会
    • Place of Presentation
      仙台国際センター(仙台)
    • Year and Date
      2017-03-24
    • Related Report
      2016 Research-status Report
  • [Presentation] タイ天然薬物 Mammea siamensis 花部のアロマターゼ阻害活性2017

    • Author(s)
      二宮清文,柴谷華苗,田邉元三,筒井 望,Chaipech Saowanee,Pongpiriyadacha Yutana,村岡 修,森川敏生
    • Organizer
      日本農芸化学会 2017 年度大会
    • Place of Presentation
      京都女子大学(京都)
    • Year and Date
      2017-03-17
    • Related Report
      2016 Research-status Report
  • [Presentation] 蓮花 (Nelumbo nucifera,花部) 含有メラニン産生抑制アルカロイド成分を指標とした品質評価2017

    • Author(s)
      奥川修平,北川仁一朗,甕 千明,田邉元三,亀井惟頼,二宮清文,吉川雅之,村岡 修,森川敏生
    • Organizer
      日本農芸化学会 2017 年度大会
    • Place of Presentation
      京都女子大学(京都)
    • Year and Date
      2017-03-17
    • Related Report
      2016 Research-status Report
  • [Presentation] タイ天然薬物 Melodorum fruticosum 由来成分の NO 産生抑制活性および全合成2017

    • Author(s)
      萬瀬貴昭,安藤恵里,田邉元三,福田梨沙,福田友紀,筒井 望,三宅史織,中屋友紀子,山添晶子,松本朋子,松田久司,二宮清文,村岡 修,森川敏生
    • Organizer
      日本農芸化学会 2017 年度大会
    • Place of Presentation
      京都女子大学(京都)
    • Year and Date
      2017-03-17
    • Related Report
      2016 Research-status Report
  • [Presentation] 延命草 (Isodon trichocarpus,地上部) 含有ジテルペノイド成分のメラニン産生抑制活性2017

    • Author(s)
      二宮清文,加藤和寛,萬瀬貴昭,今川貴仁,松本 拓,岡崎 茜,岡田枝里子,要 欣志,中村 翔,森川敏生
    • Organizer
      日本農芸化学会 2017 年度大会
    • Place of Presentation
      京都女子大学(京都)
    • Year and Date
      2017-03-17
    • Related Report
      2016 Research-status Report
  • [Presentation] ローズヒップエキスおよび trans-tiliroside の肝細胞内中性脂肪代謝促進作用2017

    • Author(s)
      長友暁史,西田典永,田中(東)幸雅,吉川雅之,村岡 修,二宮 清文,森川 敏生
    • Organizer
      第 71 回日本栄養・食糧学会大会(沖縄),2017.5.19-20.
    • Related Report
      2017 Annual Research Report
  • [Presentation] 耐糖能異常者におけるサラシアエキス配合食品による食後血糖低下作用 ~持続血糖モニターを用いたクロスオーバー試験~2017

    • Author(s)
      小林正和,赤木淳二,山口康代,山崎寛生,森川敏生,吉川雅之,村岡 修,絵本正憲
    • Organizer
      第 71 回日本栄養・食糧学会大会(沖縄),2017.5.19-20.
    • Related Report
      2017 Annual Research Report
  • [Presentation] 機能性食品素材ローズヒップエキスの有効性および安全性評価2017

    • Author(s)
      長友暁史,西田典永,吉川雅之,村岡 修,二宮 清文,森川 敏生
    • Organizer
      日本食品化学学会第 23 回総会・学術大会(三重),2017.6.1-2.
    • Related Report
      2017 Annual Research Report
  • [Presentation] ローズヒップエキスおよび trans-tiliroside の肝内脂肪低減作用2017

    • Author(s)
      長友暁史,西田典永,田中(東)幸雅,吉川雅之,村岡 修,二宮 清文,森川 敏生
    • Organizer
      第 17 回日本抗加齢医学会総会(東京),2017.6.2-4.
    • Related Report
      2017 Annual Research Report
  • [Presentation] 延命草 (Isodon trichocarpus , 地上部) 含有成分 enmein のヒト毛乳頭細胞増殖促進作用2017

    • Author(s)
      萬瀬貴昭,二宮清文,加藤和寛,楢崎紘生,岡田枝里子,山野友希,柳田満廣,要 欣志,中村 翔,森川 敏生
    • Organizer
      第 34 回和漢医薬学会大会(福岡),2017.8.26-27.
    • Related Report
      2017 Annual Research Report
  • [Presentation] センキュウ (Cnidium officinale, 根茎) の耐糖能改善作用成分の探索2017

    • Author(s)
      二宮清文,二宮 与,酒井千恵,塩谷美幸,森川敏生
    • Organizer
      第 34 回和漢医薬学会大会(福岡),2017.8.26-27.
    • Related Report
      2017 Annual Research Report
  • [Presentation] センキュウ (Cnidium officinale, 根茎) の糖消費促進活性成分の探索2017

    • Author(s)
      宮坂賢知,二宮清文,塩谷美幸,森川敏生
    • Organizer
      第 34 回和漢医薬学会大会(福岡),2017.8.26-27.
    • Related Report
      2017 Annual Research Report
  • [Presentation] 佐賀県産蓮 (Nelumbo nucifera) 花部の開花状況による含有アルカロイドの成分変動2017

    • Author(s)
      川口泰生,奥川修平,二宮清文,吉川雅之,村岡 修,森川敏生
    • Organizer
      第 34 回和漢医薬学会大会(福岡),2017.8.26-27.
    • Related Report
      2017 Annual Research Report
  • [Presentation] マテ (Ilex paraguariensis) 葉部の血中中性脂肪上昇抑制活性成分2017

    • Author(s)
      森川敏生,福井裕介,長友暁史,阪本千夏,芝坂 彩,村岡修,二宮清文
    • Organizer
      日本生薬学会第 64 回年会(千葉),2017.9.9-10.
    • Related Report
      2017 Annual Research Report
  • [Presentation] 国産蓮花 (Nelumbo nucifera, 花部) の開花度による含有アルカロイド成分の変動2017

    • Author(s)
      二宮清文,奥川修平,川口泰生,吉川雅之,村岡 修,森川敏生
    • Organizer
      日本生薬学会第 64 回年会(千葉),2017.9.9-10.
    • Related Report
      2017 Annual Research Report
  • [Presentation] カンカニクジュヨウ中主成分エキナコシド,アクテオシドのグルコース/Na+共輸送トランスポーター阻害作用2017

    • Author(s)
      島田紘明,卜部裕一,岡本雄平,川瀬篤史,李 征,森川敏生,村岡 修,岩城正宏
    • Organizer
      日本生薬学会第 64 回年会(千葉),2017.9.9-10.
    • Related Report
      2017 Annual Research Report
  • [Presentation] 川&#33422;の耐糖能改善作用成分2017

    • Author(s)
      二宮清文,宮坂賢知,塩谷美幸,二宮 与,酒井千恵,森川敏生
    • Organizer
      日本生薬学会第 64 回年会(千葉),2017.9.9-10.
    • Related Report
      2017 Annual Research Report
  • [Presentation] 茶花含有サポニンのヒト消化管由来がん細胞増殖抑制活性とその構造活性相関2017

    • Author(s)
      奥川修平,二宮清文,西田文香,甕 千明,北川仁一朗,吉川雅之,村岡 修,森川敏生
    • Organizer
      日本生薬学会第 64 回年会(千葉),2017.9.9-10.
    • Related Report
      2017 Annual Research Report
  • [Presentation] タイ天然薬物 Melodorum fruticosum含有 butenolide 類のメラニン産生抑制活性2017

    • Author(s)
      萬瀬貴昭,田邉元三,二宮清文,今川貴仁,安藤恵里,福田梨沙,福田友紀,石川文洋,村岡 修,森川敏生
    • Organizer
      日本生薬学会第 64 回年会(千葉),2017.9.9-10.
    • Related Report
      2017 Annual Research Report
  • [Presentation] ローズヒップエキスおよび trans-Tiliroside の脂肪蓄積抑制作用2017

    • Author(s)
      長友暁史,西田典永,吉川雅之,村岡 修,二宮清文,森川敏生
    • Organizer
      日本生薬学会第 64 回年会(千葉),2017.9.9-10.
    • Related Report
      2017 Annual Research Report
  • [Presentation] アルキルグリセリルアスコルビン酸のチロシナーゼ関連タンパク発現阻害によるメラニン産生抑制活性2017

    • Author(s)
      平 徳久,勝山雄志,吉岡正人,村岡 修,森川敏生
    • Organizer
      日本生薬学会第 64 回年会(千葉),2017.9.9-10.
    • Related Report
      2017 Annual Research Report
  • [Presentation] アーユルベーダ天然薬物“サラシア”由来スルホニウム塩類のジアステレオ選択的合成及び in vivo α-グルコシダーゼ阻害活性評価2017

    • Author(s)
      石川文洋,神農佳澄,薗田直樹,木内恵里,赤木淳二,二宮清文,村岡 修,吉川雅之,森川敏生,田邉元三
    • Organizer
      第 59 回天然有機化合物討論会(札幌),2017.9.20-22.
    • Related Report
      2017 Annual Research Report
  • [Presentation] Alpinia galanga から単離した新規 7-O-9' 結合型ネオリグナンの構造とメラニン産生抑制活性2017

    • Author(s)
      萬瀬貴昭,二宮清文,西 亮介,今川貴仁,Saowanee Chaipech,村岡 修,森川 敏生
    • Organizer
      第 59 回天然有機化合物討論会(札幌),2017.9.20-22.
    • Related Report
      2017 Annual Research Report
  • [Presentation] 漢薬コウズクの肝細胞内中性脂肪低減活性成分2017

    • Author(s)
      二宮清文,二宮 与,酒井千恵,萬瀬貴昭,村岡 修,森川敏生
    • Organizer
      第 38 回日本肥満学会(大阪),2017.10.7-8.
    • Related Report
      2017 Annual Research Report
  • [Presentation] センキュウ (Cnidium officinale,根茎) の糖消費促進活性成分の探索2017

    • Author(s)
      二宮清文,宮坂賢知,塩谷美幸,山本紗也,森川敏生
    • Organizer
      第 67 回日本薬学会近畿支部総会・大会(兵庫),2017.10.14.
    • Related Report
      2017 Annual Research Report
  • [Presentation] アシル化フラボノール配糖体の肝細胞における糖・脂質代謝改善作用および構造活性相関2017

    • Author(s)
      二宮清文,長友暁史,岳 誉泰,三木芳信,平 徳久,堀佑一郞,北原潤美,村岡 修,森川敏生
    • Organizer
      第 67 回日本薬学会近畿支部総会・大会(兵庫),2017.10.14.
    • Related Report
      2017 Annual Research Report
  • [Presentation] アスコルビン酸誘導体のメラニン産生抑制活性2017

    • Author(s)
      平 徳久,勝山雄志,吉岡正人,村岡 修,森川敏生
    • Organizer
      第 67 回日本薬学会近畿支部総会・大会(兵庫),2017.10.14.
    • Related Report
      2017 Annual Research Report
  • [Presentation] Alpinia galanga 由来フェニルプロパノイドメラニン産生抑制活性とその構造活性相関2017

    • Author(s)
      二宮清文,森 裕樹,萬瀬貴昭,今川貴仁,村岡 修,森川敏生
    • Organizer
      第 67 回日本薬学会近畿支部総会・大会(兵庫),2017.10.14.
    • Related Report
      2017 Annual Research Report
  • [Presentation] マツリカ (Jasminum sambac, 花部) の新規イリドイド配糖体成分2017

    • Author(s)
      二宮清文,井上尚樹,佐々木佑人,森川敏生
    • Organizer
      第 67 回日本薬学会近畿支部総会・大会(兵庫),2017.10.14.
    • Related Report
      2017 Annual Research Report
  • [Presentation] 茶花に含まれるアシル化トリテルペンサポニンのヒト消化管由来がん細胞に対する細胞増殖抑制活性2017

    • Author(s)
      二宮清文,西田文香,甕 千明,奥川修平,吉川雅之,村岡 修,森川敏生
    • Organizer
      第 67 回日本薬学会近畿支部総会・大会(兵庫),2017.10.14.
    • Related Report
      2017 Annual Research Report
  • [Presentation] センキュウ (Cnidium officinale, 根茎) の新規芳香族化合物2017

    • Author(s)
      二宮清文,山本紗也,塩谷美幸,森川敏生
    • Organizer
      第 67 回日本薬学会近畿支部総会・大会(兵庫),2017.10.14.
    • Related Report
      2017 Annual Research Report
  • [Presentation] 天然薬物“サラシア”由来 サラシノール類縁体のジアステレオ選択的合成及び in vivo α-グルコシダーゼ阻害活性評価2017

    • Author(s)
      石川文洋,神農佳澄,薗田直樹,木内恵理,赤木淳二,二宮清文,村岡 修,吉川雅之,森川敏生,田邉元三
    • Organizer
      第 35 回メディシナルケミストリーシンポジウム(名古屋),2017.10.25-27.
    • Related Report
      2017 Annual Research Report
  • [Presentation] 西洋ハーブからの肝脂肪低減を介した生活習慣病予防改善物質の探索2017

    • Author(s)
      二宮清文,森川敏生
    • Organizer
      第 7 回食品薬学シンポジウム(京都),2017.10.28-29.
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] メース (Myristica fragrans,仮種皮) のケモカイン受容体 CCR3 アンタゴニスト様作用を指標とした抗アレルギー作用成分の探索2017

    • Author(s)
      森川敏生,八幡郁子,松尾一彦,西田枝里子,二宮清文,義江 修,村岡 修,中山隆志
    • Organizer
      第 7 回食品薬学シンポジウム(京都),2017.10.28-29.
    • Related Report
      2017 Annual Research Report
  • [Presentation] アンディローバ (Carapa guianensis) 含有リモノイド成分の脂肪性肝炎抑制作用2017

    • Author(s)
      二宮清文,酒井千恵,丸本真輔,長友暁史,村岡 修,菊池 崇,山田剛司,田中麗子,森川敏生
    • Organizer
      第 7 回食品薬学シンポジウム(京都),2017.10.28-29.
    • Related Report
      2017 Annual Research Report
  • [Presentation] フェニルプロパノイドの肝臓中脂肪低減を介した耐糖能改善作用2016

    • Author(s)
      二宮清文,萬瀬貴昭,二宮 与,森 祐樹,酒井千恵,村岡 修,森川敏生
    • Organizer
      第 34 回メディシナルケミストリーシンポジウム
    • Place of Presentation
      つくば国際会議場(つくば)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Research-status Report
  • [Presentation] ブラジル生薬アンディローバ由来リモノイド成分の脂肪肝低減作用2016

    • Author(s)
      森川敏生,二宮清文,二宮 与,丸本真輔,酒井千恵,村岡 修,菊池 崇,山田剛司,田中麗子
    • Organizer
      第 60 回香料・テルペンおよび精油化学に関する討論会
    • Place of Presentation
      東京農業大学(網走)
    • Year and Date
      2016-10-29
    • Related Report
      2016 Research-status Report
  • [Presentation] タイ天然薬物 Mammea siamensis 由来クマリン成分のアロマターゼ阻害活性2016

    • Author(s)
      森川敏生,二宮清文,柴谷華苗,田邉元三,筒井 望,Chaipech Saowanee,Pongpiriyadacha Yutana,村岡 修
    • Organizer
      第 60 回香料・テルペンおよび精油化学に関する討論会
    • Place of Presentation
      東京農業大学(網走)
    • Year and Date
      2016-10-29
    • Related Report
      2016 Research-status Report
  • [Presentation] 釣藤鈎の機能性成分-神経突起伸長作用成分およびその作用機序-2016

    • Author(s)
      二宮清文,河端千尋,今野拓哉,南野 享,菅原 碧,森川敏生
    • Organizer
      第 21 回天然薬物の開発と応用シンポジウム
    • Place of Presentation
      千葉大学(千葉)
    • Year and Date
      2016-10-27
    • Related Report
      2016 Research-status Report
  • [Presentation] タイ天然薬物 Melodorum fruticosum 由来 butenolide 類の全合成および NO 産生抑制活性評価2016

    • Author(s)
      萬瀬貴昭,田邉元三,福田梨沙,福田友紀,筒井 望,三宅史織,中屋友紀子,山添晶子,松本朋子,松田久司,二宮清文,村岡 修,森川敏生
    • Organizer
      第 21 回天然薬物の開発と応用シンポジウム
    • Place of Presentation
      千葉大学(千葉)
    • Year and Date
      2016-10-27
    • Related Report
      2016 Research-status Report
  • [Presentation] Hepatoprotective triterpene saponin constituents from roots of Bupleurum falcatum2016

    • Author(s)
      Takuya Konno, Kiyofumi Ninomiya, Masayuki Yoshikawa, Hisashi Matsuda, Toshio Morikawa
    • Organizer
      The 12th International Conference on Protein Phosphatase (ICPP12)
    • Place of Presentation
      Kindai University, Osaka
    • Year and Date
      2016-10-27
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Limonoids from Brazilian folk medicine, Andiroba, with fat metabolizing activity in hepatocytes2016

    • Author(s)
      Kiyofumi Ninomiya, Kumi Ninomiya, Chie Sakai, Osamu Muraoka, Takashi Kikuchi, Takeshi Yamada, Reiko Tanaka, Toshio Morikawa
    • Organizer
      The 12th International Conference on Protein Phosphatase (ICPP12)
    • Place of Presentation
      Kindai University, Osaka
    • Year and Date
      2016-10-27
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Diterpenoids from the Aerial Part of Isodon trichocapus with Melanogenesis Inhibitory Activity2016

    • Author(s)
      Yoshiaki Manse, Kiyofumi Ninomiya, Akane Okazaki, Eriko Okada, Takahito Imagawa, Kinji Kaname, Sho Nakamura, Toshio Morikawa
    • Organizer
      The 12th International Conference on Protein Phosphatase (ICPP12)
    • Place of Presentation
      Kindai University, Osaka
    • Year and Date
      2016-10-27
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] ケモカイン受容体を標的とした天然由来シーズの探索研究 (2):ロウバイカ (Chimonanthus praecox 花蕾部) の CCR6 および CCR7 アンタゴニスト活性成分2016

    • Author(s)
      森川敏生,松尾一彦,奥川修平,北川仁一朗,二宮清文,中西勇介,村岡 修,中山隆志
    • Organizer
      日本生薬学会第 63 回年会
    • Place of Presentation
      富山国際会議場{富山)
    • Year and Date
      2016-09-24
    • Related Report
      2016 Research-status Report
  • [Presentation] サイコ (Bupleurum falcatum L.) の肝細胞内中性脂肪代謝作用2016

    • Author(s)
      二宮清文,今野拓哉,矢田佳凜,森川敏生
    • Organizer
      日本生薬学会第 63 回年会
    • Place of Presentation
      富山国際会議場{富山)
    • Year and Date
      2016-09-24
    • Related Report
      2016 Research-status Report
  • [Presentation] 延命草 (Isodon trichocarpus, 地上部) のメラニン産生抑制活性成分2016

    • Author(s)
      二宮清文,萬瀬貴昭,今川貴仁,松本 拓,岡崎 茜,岡田枝里子,要 欣志,中村 翔,森川敏生
    • Organizer
      日本生薬学会第 63 回年会
    • Place of Presentation
      富山国際会議場{富山)
    • Year and Date
      2016-09-24
    • Related Report
      2016 Research-status Report
  • [Presentation] タイ天然薬物 Mammea siamensis 花部の機能性成分 (6)―含有成分のがん細胞増殖抑制活性―2016

    • Author(s)
      二宮清文,杉田秀美,村木謙一,佐伯竣介,末吉真弓,Chaipech Saowanee,Pongpiriyadacha Yutana,早川堯夫,村岡 修,森川敏生
    • Organizer
      日本生薬学会第 63 回年会
    • Place of Presentation
      富山国際会議場{富山)
    • Year and Date
      2016-09-24
    • Related Report
      2016 Research-status Report
  • [Presentation] タイ天然薬物 Mammea siamensis 花部の機能性成分 (7)―含有クマリン成分のアロマターゼ阻害活性―2016

    • Author(s)
      二宮清文,柴谷華苗,田邉元三,筒井 望,末吉真弓,佐伯竣介,杉田秀美,Chaipech Saowanee,Pongpiriyadacha Yutana,早川堯夫,村岡 修,森川敏生
    • Organizer
      日本生薬学会第 63 回年会
    • Place of Presentation
      富山国際会議場{富山)
    • Year and Date
      2016-09-24
    • Related Report
      2016 Research-status Report
  • [Presentation] 茶花由来サポニンのヒト消化管由来がん細胞増殖抑制活性 ―chakasaponin II およびその誘導体の構造活性相関―2016

    • Author(s)
      二宮清文,甕 千明,西田文香,奥川修平,北川仁一朗,吉川雅之,村岡 修,森川敏生
    • Organizer
      日本生薬学会第 63 回年会
    • Place of Presentation
      富山国際会議場{富山)
    • Year and Date
      2016-09-24
    • Related Report
      2016 Research-status Report
  • [Presentation] 茶花由来サポニンのヒト消化管由来がん細胞増殖抑制活性―chakasaponinの作用機序―2016

    • Author(s)
      二宮清文,甕 千明,西田文香,奥川修平,北川仁一朗,吉川雅之,村岡 修,森川敏生
    • Organizer
      日本生薬学会第 63 回年会
    • Place of Presentation
      富山国際会議場{富山)
    • Year and Date
      2016-09-24
    • Related Report
      2016 Research-status Report
  • [Presentation] タイ天然薬物 Melodorum fruticosum 由来NO産生抑制活性を有する Butenolide 類の全合成2016

    • Author(s)
      田邉元三,薗田直樹,福田梨沙,福田友紀,萬瀬貴昭,筒井 望,二宮清文,森川敏生,村岡 修
    • Organizer
      第 58 回天然有機化合物討論会
    • Place of Presentation
      東北大学(仙台)
    • Year and Date
      2016-09-14
    • Related Report
      2016 Research-status Report
  • [Presentation] アンディローバ(Carapa guianensis)含有リモノイド成分の脂肪性肝炎抑制作用2016

    • Author(s)
      森川敏生,二宮清文,二宮 与,丸本真輔,酒井千恵,宮澤聖也,尾関快天,松尾菜都子,村岡 修,菊地 崇,山田剛司,田中麗子
    • Organizer
      第 58 回天然有機化合物討論会
    • Place of Presentation
      東北大学(仙台)
    • Year and Date
      2016-09-14
    • Related Report
      2016 Research-status Report
  • [Presentation] Diterpenoids with melanogenesis inhibitory activity in the aerial part of Isodon trichocapus2016

    • Author(s)
      Yoshiaki Manse, Kiyofumi Ninomiya, Akane Okazaki, Eriko Okada, Takahito Imagawa, Kinji Kaname, Sho Nakamura, Toshio Morikawa
    • Organizer
      International Symposium on Natural Products for the Future 2016 (ISNPF2016)
    • Place of Presentation
      Tokushima Bunri University, Tokushima
    • Year and Date
      2016-09-01
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Quantitative determination of alkaloids in lotus flower (the flower buds of Nelumbo nucifera) and their melanogenesis inhibitory activity2016

    • Author(s)
      Toshio Morikawa, Shuhei Okugawa, Niichiro Kitagawa, Kiyofumi Ninomiya, Chiaki Motai, Iyori Kamei, Masayuki Yoshikawa, Genzoh Tanabe, I-Jung Lee, Osamu Muraoka
    • Organizer
      International Symposium on Natural Products for the Future 2016 (ISNPF2016)
    • Place of Presentation
      Tokushima Bunri University, Tokushima
    • Year and Date
      2016-09-01
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Limonoids from flower and seed oil of Carapa guianensis with fat metabolizing activity in hepatocytes2016

    • Author(s)
      Kiyofumi Ninomiya, Kumi Ninomiya, Chie Sakai, Osamu Muraoka, Takashi Kikuchi, Takeshi Yamada, Reiko Tanaka, Toshio Morikawa
    • Organizer
      International Symposium on Natural Products for the Future 2016 (ISNPF2016)
    • Place of Presentation
      Tokushima Bunri University, Tokushima
    • Year and Date
      2016-09-01
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Coumarin constituents from the flowers of Mammea siamensis with aromatase inhibitory activity2016

    • Author(s)
      Kiyofumi Ninomiya, Kanae Shibatani, Mayumi Sueyoshi, Shunsuke Saeki, Saowanee Chaipech, Yutana Pongpiriyadacha, Takao Hayakawa, Osamu Muraoka, Toshio Morikawa
    • Organizer
      International Symposium on Natural Products for the Future 2016 (ISNPF2016)
    • Place of Presentation
      Tokushima Bunri University, Tokushima
    • Year and Date
      2016-09-01
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Growth inhibitory effects of coumarins from the flowers of Mammea siamensis on human digestive tract carcinoma cell lines2016

    • Author(s)
      Kiyofumi Ninomiya, Kenichi Muraki, Mayumi Sueyoshi, Shunsuke Saeki, Chiaki Motai, Saowanee Chaipech, Yutana Pongpiriyadacha, Takao Hayakawa, Osamu Muraoka, Toshio Morikawa
    • Organizer
      International Symposium on Natural Products for the Future 2016 (ISNPF2016)
    • Place of Presentation
      Tokushima Bunri University, Tokushima
    • Year and Date
      2016-09-01
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Inhibitory effects of constituents from aril of Myristica fragrans (Mace) on theophylline-stimulated melanogenesis in B16 4A5 cells2016

    • Author(s)
      Kiyofumi Ninomiya, Takahito Imagawa, Ikuko Hachiman, Chiaki Motai, Eriko Nishida, Takao Hayakawa, Osamu Muraoka, Toshio Morikawa
    • Organizer
      International Symposium on Natural Products for the Future 2016 (ISNPF2016)
    • Place of Presentation
      Tokushima Bunri University, Tokushima
    • Year and Date
      2016-09-01
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Triterpene saponins from roots of Bupleurum falcatum with triglyceride metabolism-promoting activity in high glucose-pretreated HepG2 cells2016

    • Author(s)
      Kiyofumi Ninomiya, Takuya Konno, Karin Yada, Toshio Morikawa
    • Organizer
      International Symposium on Natural Products for the Future 2016 (ISNPF2016)
    • Place of Presentation
      Tokushima Bunri University, Tokushima
    • Year and Date
      2016-09-01
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Anti-proliferative effects of chakasaponin II and related compounds from Camellia sinensis on human digestive tract carcinoma cell lines2016

    • Author(s)
      Chiaki Motai, Niichiro Kitagawa, Kiyofumi Ninomiya, Ayaka Nishida, Shuhei Okugawa, Masayuki Yoshikawa, Osamu Muraoka, Toshio Morikawa
    • Organizer
      International Symposium on Natural Products for the Future 2016 (ISNPF2016)
    • Place of Presentation
      Tokushima Bunri University, Tokushima
    • Year and Date
      2016-09-01
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] コウズク (Alpinia galanga,果実) の耐糖能改善作用成分2016

    • Author(s)
      二宮清文,二宮 与,酒井千恵,萬瀬貴昭,村岡 修,早川堯夫,森川敏生
    • Organizer
      第 33 回和漢医薬学会学術大会
    • Place of Presentation
      星薬科大学(東京)
    • Year and Date
      2016-08-27
    • Related Report
      2016 Research-status Report
  • [Presentation] センキュウ (Cnidium officinale, 根茎) の耐糖能改善作用物質2016

    • Author(s)
      二宮 与,二宮清文,酒井千恵,塩谷美幸,森川敏生
    • Organizer
      第 33 回和漢医薬学会学術大会
    • Place of Presentation
      星薬科大学(東京)
    • Year and Date
      2016-08-27
    • Related Report
      2016 Research-status Report
  • [Presentation] 柴胡含有サポニン成分の肝細胞内中性脂肪低減活性成分2016

    • Author(s)
      今野拓哉,二宮清文,矢田佳凜,森川敏生
    • Organizer
      第 33 回和漢医薬学会学術大会
    • Place of Presentation
      星薬科大学(東京)
    • Year and Date
      2016-08-27
    • Related Report
      2016 Research-status Report
  • [Presentation] Phthalides from rhizomes of Cnidium officinale accelerate metabolism of triglyceride in hepatocytes2016

    • Author(s)
      Kiyofumi Ninomiya, Chie Sakai, Kumi Ninomiya, Miyuki Shiotani, Toshio Morikawa
    • Organizer
      9th Joint Natural Products Conference 2016 (JNPC2016)
    • Place of Presentation
      Copenhagen, Denmark
    • Year and Date
      2016-07-24
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Triterpene saponin constituents from roots of Bupleurum falcatum: Hepatoprotective effects on D-galactosamine-induced cell damage2016

    • Author(s)
      Takuya Konno, Kiyofumi Ninomiya, Masayuki Yoshikawa, Hisashi Matsuda, Toshio Morikawa
    • Organizer
      9th Joint Natural Products Conference 2016 (JNPC2016)
    • Place of Presentation
      Copenhagen, Denmark
    • Year and Date
      2016-07-24
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Andiroba (Carapa guianensis) 含有リモノイド成分の肝細胞内中性脂肪低下作用2016

    • Author(s)
      二宮清文,二宮 与,酒井千恵,村岡 修,菊地 崇,山田剛司,田中麗子,森川敏生
    • Organizer
      第 3 回肝臓と糖尿病・代謝研究会
    • Place of Presentation
      石川県立音楽堂(金沢)
    • Year and Date
      2016-07-16
    • Related Report
      2016 Research-status Report
  • [Presentation] 茶花由来アシル化サポニンのヒト口腔癌由来細胞株 HSC-2 に対する細胞増殖抑制活性2016

    • Author(s)
      森川敏生,北川仁一朗,甕 千明,奥川修平,西田文香,吉川雅之,村岡 修,二宮清文
    • Organizer
      第 70 回日本栄養・食糧学会大会
    • Place of Presentation
      武庫川女子大学(神戸)
    • Year and Date
      2016-05-13
    • Related Report
      2016 Research-status Report
  • [Presentation] 延命草由来ジテルペノイド成分のメラニン産生抑制作用2016

    • Author(s)
      二宮清文,萬瀬貴昭,岡田枝里子,松本 拓,岡﨑 茜,要 欣志, 中村 翔, 森川敏生
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2016-03-26
    • Related Report
      2015 Research-status Report
  • [Presentation] アンデローバ含有成分の脂肪肝低減作用成分2016

    • Author(s)
      二宮清文,酒井千恵,村岡 修,菊地 崇,山田剛司,田中麗子, 森川敏生
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2016-03-26
    • Related Report
      2015 Research-status Report
  • [Presentation] メラニン産生抑制活性を有する蓮華含有アルカロイド成分の安定性評価2016

    • Author(s)
      二宮清文, 奥川修平, 甕 千明, 北川仁一朗, 田邉元三, 吉川雅之, 村岡 修, 森川敏生
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2016-03-26
    • Related Report
      2015 Research-status Report
  • [Presentation] ケープアロエ葉末の抗炎症作用成分2016

    • Author(s)
      二宮清文, 大山更紗, 赤木淳二, 松本 拓, 松尾菜都子, 尾関快天, 岡田拓也, 吉田郁代, 森川敏生
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2016-03-26
    • Related Report
      2015 Research-status Report
  • [Presentation] センキュウ(Cnidium officinale, 根茎)の抗炎症作用成分2016

    • Author(s)
      二宮清文, 塩谷美幸, 尾関快天, 松尾菜都子, 森川敏生
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2016-03-26
    • Related Report
      2015 Research-status Report
  • [Presentation] タイ天然薬物 Melodorum fruticosum 由来 NO 産生抑制活性を有する Butenolide 類の 全合成2016

    • Author(s)
      田邉元三, 森川敏生, 小川哲平, 薗田直樹, 至田智行, 萬瀬貴昭, 二宮清文, 筒井 望, 村岡 修
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2016-03-26
    • Related Report
      2015 Research-status Report
  • [Presentation] Phthalides from rhizomes of Cnidium officinale as new leads for fatty liver therapeutic candidates2015

    • Author(s)
      Ninomiya K., Sakai C., Shiotani M., Morikawa T.
    • Organizer
      7th Asian Association of Schools of Pharmacy (AASP) Conference
    • Place of Presentation
      GIS NTU Convention Centre (Taipei), Taiwan
    • Year and Date
      2015-10-30
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Hepatoprotective triterpene saponins from roots of Bupleurum falcatum2015

    • Author(s)
      Konno T., Ninomiya K., Yoshikawa M., Matsuda H., Morikawa T.
    • Organizer
      7th Asian Association of Schools of Pharmacy (AASP) Conference
    • Place of Presentation
      GIS NTU Convention Centre (Taipei), Taiwan
    • Year and Date
      2015-10-30
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 蓮華 (Nelumbo nucifera,花部) のメラニン産生抑制活性成分を指標とした品質評価2015

    • Author(s)
      森川敏生,北川仁一朗,奥川修平,甕 千明,田邉元三,亀井惟頼,二宮清文,吉川雅之,村岡 修
    • Organizer
      第 6 回食品薬学シンポジウム
    • Place of Presentation
      岡山大学津島キャンパス(岡山)
    • Year and Date
      2015-10-30
    • Related Report
      2015 Research-status Report
  • [Presentation] ケープアロエの炎症性サイトカインTNF-alpha 誘発細胞障害抑制作用成分2015

    • Author(s)
      大山更紗,赤木淳二,松本 拓,松尾菜都子,尾関快天,吉田郁代,二宮清文,森川敏生
    • Organizer
      第 65 回日本薬学会近畿支部総会・大会
    • Place of Presentation
      大阪大谷大学(大阪)
    • Year and Date
      2015-10-17
    • Related Report
      2015 Research-status Report
  • [Presentation] タイ天然薬物 Mammea siamensis 花部の機能性成分(5)-新規プレニルクマリン mammeasin CおよびDのアロマターゼ阻害活性-2015

    • Author(s)
      二宮清文,柴谷華苗,佐伯竣介,末吉真弓,Chaipech Saowanee,Pongpiriyadacha Yutana,早川堯夫,村岡 修,森川敏生
    • Organizer
      第 65 回日本薬学会近畿支部総会・大会
    • Place of Presentation
      大阪大谷大学(大阪)
    • Year and Date
      2015-10-17
    • Related Report
      2015 Research-status Report
  • [Presentation] タイ天然薬物 Melodorum fruticosum 由来 NO 産生抑制活性を有する Butenolide 類の全合成2015

    • Author(s)
      至田智之,田邉元三,森川敏生,萬瀬貴昭,小川哲平,薗田直樹,二宮清文,筒井 望,村岡 修
    • Organizer
      第 65 回日本薬学会近畿支部総会・大会
    • Place of Presentation
      大阪大谷大学(大阪)
    • Year and Date
      2015-10-17
    • Related Report
      2015 Research-status Report
  • [Presentation] ミシマサイコ (Bupleurum falcatum L.) 根部の肝障害抑制活性成分2015

    • Author(s)
      今野拓哉,二宮清文,吉川雅之,松田久司,森川敏生
    • Organizer
      第 65 回日本薬学会近畿支部総会・大会
    • Place of Presentation
      大阪大谷大学(大阪)
    • Year and Date
      2015-10-17
    • Related Report
      2015 Research-status Report
  • [Presentation] アンデローバ含有リモノイドの肝細胞内中性脂肪低減作用2015

    • Author(s)
      二宮清文,酒井千恵,村岡 修,菊地 崇,山田剛司,田中麗子,森川敏生
    • Organizer
      日本生薬学会第 62 回年会
    • Place of Presentation
      長良川国際会議場(岐阜)
    • Year and Date
      2015-09-11
    • Related Report
      2015 Research-status Report
  • [Presentation] メース(Myristica fragrans,仮種皮)の機能性成分(6)-新規ネオリグナン成分の化学構造-2015

    • Author(s)
      二宮清文,八幡郁子,田邉元三,早川堯夫,村岡 修,森川敏生
    • Organizer
      日本生薬学会第 62 回年会
    • Place of Presentation
      長良川国際会議場(岐阜)
    • Year and Date
      2015-09-11
    • Related Report
      2015 Research-status Report
  • [Presentation] タイ天然薬物 Mammea siamensis 花部の抗炎症作用成分2015

    • Author(s)
      森川敏生,二宮清文,佐伯竣介,宮澤聖也,Chaipech Saowanee,Pongpiriyadacha Yutana,早川堯夫,村岡 修
    • Organizer
      第 59 回香料・テルペンおよび精油化学に関する討論会
    • Place of Presentation
      近畿大学(大阪)
    • Year and Date
      2015-09-05
    • Related Report
      2015 Research-status Report
  • [Presentation] タイ天然薬物 Melodorum fruticosum の由来 NO 産生抑制活性を有する Butenolide 類の全合成2015

    • Author(s)
      田邉元三,森川敏生,小川哲平,薗田直樹,至田智行,萬瀬貴昭,二宮清文,筒井 望,村岡 修
    • Organizer
      第 59 回香料・テルペンおよび精油化学に関する討論会
    • Place of Presentation
      近畿大学(大阪)
    • Year and Date
      2015-09-05
    • Related Report
      2015 Research-status Report
  • [Presentation] メース(Myristica fragrans,仮種皮)の新規ネオリグナン成分2015

    • Author(s)
      八幡郁子,二宮清文,尾関快天,西田枝里子,早川堯夫,村岡 修,森川敏生
    • Organizer
      第 59 回香料・テルペンおよび精油化学に関する討論会
    • Place of Presentation
      近畿大学(大阪)
    • Year and Date
      2015-09-05
    • Related Report
      2015 Research-status Report
  • [Presentation] Bioactive constituents from hooks of Uncaria rhynchophylla -effects on TNF-alpha-induced cell damage and neurite outgrowth-2015

    • Author(s)
      Ninomiya K., Kawabata C.,Minamino T., Ozeki K., Matsuo N., Hayakawa T., Morikawa T.
    • Organizer
      Inaugural Symposium of the Phytochemical Society of Asia 2015 (ISPSA2015)
    • Place of Presentation
      Tokushima Bunri University (Tokushima), Japan
    • Year and Date
      2015-08-29
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Chemokine receptor CCR3 antagonist from arils of Myristica fragrans2015

    • Author(s)
      Morikawa T., Hachiman I., Matsuo K., Ninomiya K., Muraoka O., Hayakawa T., Nakayama T.
    • Organizer
      Inaugural Symposium of the Phytochemical Society of Asia 2015 (ISPSA2015)
    • Place of Presentation
      Tokushima Bunri University (Tokushima), Japan
    • Year and Date
      2015-08-29
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Quantitative determination of potent melanogenesis inhibitors in "lotus flower", the flower buds of Nelumbo nucifera2015

    • Author(s)
      Okugawa S., Ninomiya K., Kitagawa N., Matsumoto T., Kamei I., Lee I.-J., Yoshikawa M., Muraoka O., Morikawa T.
    • Organizer
      Inaugural Symposium of the Phytochemical Society of Asia 2015 (ISPSA2015)
    • Place of Presentation
      Tokushima Bunri University (Tokushima), Japan
    • Year and Date
      2015-08-29
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] アロエ属植物による炎症性サイトカイン TNF-alpha の感受性低減作用2015

    • Author(s)
      大山更紗,赤木淳二,松本 拓,松尾菜都子,尾関快天,吉田郁代,二宮清文,森川敏生
    • Organizer
      第 32 回和漢医薬学会大会
    • Place of Presentation
      富山国際会議場(富山)
    • Year and Date
      2015-08-22
    • Related Report
      2015 Research-status Report
  • [Presentation] センキュウ(Cnidiumofficinale,根茎) の機能性成分(3)-含有フタリド成分の一酸化窒素産生抑制活性-2015

    • Author(s)
      塩谷美幸,二宮清文,尾関快天,松尾菜都子,森川敏生
    • Organizer
      第 32 回和漢医薬学会大会
    • Place of Presentation
      富山国際会議場(富山)
    • Year and Date
      2015-08-22
    • Related Report
      2015 Research-status Report
  • [Presentation] ニクズクイ(Myristica fragrans,仮種皮) の脱顆粒抑制作用成分2015

    • Author(s)
      八幡郁子,二宮清文,松田久司,畑 裕基,菅原かおる,吉川雅之,早川堯夫,村岡 修,森川敏生
    • Organizer
      第 32 回和漢医薬学会大会
    • Place of Presentation
      富山国際会議場(富山)
    • Year and Date
      2015-08-22
    • Related Report
      2015 Research-status Report
  • [Presentation] ハス (Nelumbo nicifera) 花部の抗炎症作用アルカロイド成分2015

    • Author(s)
      北川仁一朗,二宮清文,奥川修平,松尾菜都子,吉川雅之,村岡 修,森川敏生
    • Organizer
      第 32 回和漢医薬学会大会
    • Place of Presentation
      富山国際会議場(富山)
    • Year and Date
      2015-08-22
    • Related Report
      2015 Research-status Report
  • [Presentation] Search for chemokine receptor CCR3 selective antagonist as anti-allergic principles from Mace, the arils of Myristica fragrans2015

    • Author(s)
      Hachiman I., Matsuo K., Ninomiya K., Muraoka O., Hayakawa T., Nakayama T., Morikawa T.
    • Organizer
      12th Asian Congress of Nutrition (ACN2015)
    • Place of Presentation
      Pacifico Yokohama (Yokohama), Japan
    • Year and Date
      2015-05-14
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Remarks] 近畿大学薬学総合研究所食品薬学研究室HP

    • URL

      http://www.phar.kindai.ac.jp/medfood/

    • Related Report
      2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2022-02-28  

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