Analysis of clinical manifestations or increased factor of nontuberculous mycobacteria disease and its clinical application
Project/Area Number |
15K08049
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Environmental and hygienic pharmacy
|
Research Institution | Meijo University |
Principal Investigator |
|
Project Period (FY) |
2015-04-01 – 2020-03-31
|
Project Status |
Completed (Fiscal Year 2019)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | Mycobacterium avium / 肺M. avium症 / 病態 / 感染様式 / 宿主特異性 / ゲノム解析 / Mycobacterium avium感染症 / 増加要因 / pMAH135プラスミド / MATR-VNTR型別解析 |
Outline of Final Research Achievements |
To assess the relationship between the different pathological or clinical manifestations of Mycobacterium avium disease and bacterial factors, we mainly performed comparative genome analysis using clinical isolates from patients with various symptoms. Our analysis showed that M. avium strains which cause pulmonary and disseminated disease possess genetically distinct features. Comparative genome analysis of 79 M. avium strains comprising four subspecies revealed the presence of genetic elements specific to each lineage, and identified potential genetic determinants associated with not only the progression of pulmonary disease but also the host range characteristics of M. avium. Of note, this analysis indicated an association between the progression of pulmonary M. avium disease and several virulence genes including pMAH135. These results suggest that bacterial factors play an important role in the cause of the diverse pathological or clinical manifestations of M. avium disease.
|
Academic Significance and Societal Importance of the Research Achievements |
肺M. avium症の臨床上の問題点として変則的な病態が挙げられ,さらにM. avium症の感染様式や宿主特異性の違いにおいて,これらは宿主側の要因だけではなく病原体側の遺伝学的特性に起因すると考えられるが詳細は不明であった。 本研究課題により得られた研究成果により,上記問題点の要因を決定している病原体側の遺伝学的特性や特定遺伝子の存在が明らかになり,M. avium症の問題点の解明に大きく寄与することができた。これらの知見は,本感染症の病態や感染様式を理解する上で重要な情報となり,学術的・社会的意義は大きいと考える。
|
Report
(6 results)
Research Products
(32 results)
-
-
-
-
-
-
-
-
[Journal Article] Genetic diversity of clinical Mycobacterium avium subsp. hominissuis and Mycobacterium intracellulare isolates causing pulmonary diseases recovered from different geographical regions2015
Author(s)
Kazuya Ichikawa, Jakko van Ingen, Won-Jung Koh, Dirk Wagner, Max Salfinger, Takayuki Inagaki, Kei-ichi Uchiya, Taku Nakagawa, Kenji Ogawag, Kiyofumi Yamadaa, Tetsuya Yagi
-
Journal Title
Infect. Genet. Evol.
Volume: 36
Pages: 250-255
DOI
Related Report
Peer Reviewed / Int'l Joint Research
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-