| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Outline of Final Research Achievements |
When non-anticoagulant heparin is conjuated with aliphatic amines, it comes to form self-assembling nanomicelles and exhibit remarkable suppressive effect on the production of proinflammatory cytokines in lipopolysaccharide(LPS)-stimulated macrophages. The present study demonstrated that the anti-inflammatory effect can be observed with not only heparin but other glycosaminoglycans, being stronger as their degree of sulfation is higher. In addition, the time-series data of expression of a variety of genes following LPS stimulation were analyzed based on a mathematical model. The quantitative transcription network analysis indicated that the heparin nanoparticles appeared to selectively inhibit the activation of TAK1-IKK-NFkappaB pathway following LPS stimulation.
|
